Mortalidad antes y después de la vacunación de Covid-19 del 2020-2021

Revista Medica Sinergia, Journal Year: 2024, Volume and Issue: 9(4), P. e1139 - e1139

Published: April 1, 2024

Este artículo de publicación presenta una investigación sobre el impacto la vacunación para disminución mortalidad y positividad casos COVID-19 en Honduras. Se recopilaron datos hospitales centros salud Región Metropolitana San Pedro Sula región departamental Copán. analizó un total 123 148 muestras, las cuales 47 578 fueron positivas, con del 38.63%. registraron 1827 fallecimientos ambos lugares. Además, se observó reducción número muertes los meses octubre noviembre, debido a participación proceso vacunación. destaca importancia que personas aún no han vacunado lo hagan.

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COVID-19: Unveiling the Neuropsychiatric Maze—From Acute to Long-Term Manifestations

Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1147 - 1147

Published: May 22, 2024

The SARS-CoV-2 virus has spread rapidly despite implementing strategies to reduce its transmission. disease caused by this been associated with a diverse range of symptoms, including common neurological manifestations such as dysgeusia, anosmia, and myalgias. Additionally, numerous cases severe complications have reported, encephalitis, stroke, seizures, Guillain–Barré syndrome, among others. Given the high prevalence in disease, objective review is analyze mechanisms which can affect nervous system, from direct invasion aberrant activation immune system other involved neuropsychiatric manifestations, gain better understanding thus facilitate search for effective therapeutic strategies.

Language: Английский

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Navigating uncertainty: occupational therapists’ experiences of Long COVID management in Germany, Austria and Switzerland

Disability and Rehabilitation, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10

Published: July 3, 2024

Purpose Long COVID presents global challenges for healthcare professionals. Occupational therapists responded by seeking effective treatment strategies. The approaches of occupational supporting long-haulers in German-speaking countries remain under-explored. purpose this study is to explore how Germany, Austria and Switzerland navigate apply profession-specific strategies the new clinical landscape care.

Language: Английский

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Multiomics Reveals a Mechanism: Glycogen Synthesis, Galactose Metabolism, and Ethanol Degradation Pathways, the Durable Role of Neutralizing Antibodies in Preventing COVID-19

ACS Omega, Journal Year: 2024, Volume and Issue: 9(42), P. 42757 - 42765

Published: Oct. 10, 2024

Since the emergence and rapid dissemination of Coronavirus disease 2019 (COVID-19), over 774 million individuals globally have achieved recovery to today. There is some case flashing into here there all world. Neutralizing Antibody (NAb) against Severe Acute Respiratory Syndrome Coronavirus-Type 2 (SARS-CoV-2) play a paramount role in conferring effective lasting protection for several months. This protective effect decreases with time thus increasing chance reinfection. Therefore, we can provide body by maintaining NAb level. However, how maintain Nab level remains elusive. To address this question, recruited 80 patients confirmed COVID-19 collected 480 consecutive blood samples performed testing six months after their recovery. The were categorized two groups: low-titer group (≤20) high-titer (>20). achieve comprehensive understanding changes level, 16 serum randomly selected an untargeted metabolomic analysis, whereas 9 designated label-free proteomic analysis. We successfully identified differentially expressed 751 metabolites 845 proteins. In both low high titer groups, three key differential proteins, phosphoglucose translocase 2(PGM2), UDP-Glc 4-epimerase (GALE), alcohol dehydrogenase 1B (ADH1B), that important roles fluctuating through glycogen synthesis, galactose metabolism ethanol degradation pathways. These proteins may serve as potential biomarkers enhancing immune recovering from COVID-19.

Language: Английский

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Longitudinal 1H NMR-Based Metabolomics in Saliva Unveils Signatures of Transition from Acute to Post-Acute Phase of SARS-CoV-2 Infection

Viruses, Journal Year: 2024, Volume and Issue: 16(11), P. 1769 - 1769

Published: Nov. 13, 2024

COVID-19 can range from a mild to severe acute respiratory syndrome and also could result in multisystemic damage. Additionally, many people develop post-acute symptoms associated with immune metabolic disturbances response viral infection, requiring longitudinal multisystem studies understand the complexity of pathophysiology. Here, we conducted

Language: Английский

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Fatigue and quality of life among older coronavirus disease 2019 survivors

Journal of Geriatric Mental Health, Journal Year: 2024, Volume and Issue: 11(2), P. 88 - 90

Published: July 1, 2024

ABSTRACT Background: Fatigue is a common post-illness symptom that significantly impacts the quality of life (QoL), especially among elderly individuals. The long-term effects COVID-19 on fatigue and QoL in survivors remain under-explored. Aims Objectives: This study aims to examine prevalence its impact survivors. Materials Methods: Data were collected from tertiary care hospital India, involving 99 participants aged over 50 years. Sociodemographic clinical data obtained via structured interviews. was assessed using Multidimensional Inventory-20 questionnaire, while measured with WHOQOL-BREF Scale. Results: Significant positive correlations found between age fatigue. scores notably higher physical reduced activity domains. Overall negatively correlated scores. Conclusion: underscores importance addressing post-COVID-19 for survivors, as their life.

Language: Английский

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Epigenetic Age Acceleration in Surviving versus Deceased COVID-19 Patients with Acute Respiratory Distress Syndrome following Hospitalization

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 19, 2023

Abstract Aging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecular hallmarks such epigenetic alterations telomere attenuation reflect the biological process of aging. Epigenetic clocks have shown to be valuable tools measuring age variety tissues samples. As such, these can determine accelerated aging time-to-mortality across various tissues. Previous reports attrition acceleration following SARS-CoV-2 infection. However, effect on outcome (death/recovery) patients with Acute Respiratory Distress Syndrome (ARDS) not well investigated. In this study, we measured DNA methylation 87 cases ARDS under mechanical ventilation. Furthermore, compared dynamic changes multiples time-points until recovery or death. was using Horvath, Hannum, DNAm skin blood, GrimAge, PhenoAge clocks, whereas length calculated surrogate marker DNAmTL. Our analysis revealed significant but no cases. addition, observed deceleration at inclusion vs end follow-up recovered deceased certain clocks. When comparing (EAA), detected EAA both Horvath The DNAmTL measurements COVID19 between change when who those died. conclusion, associated treatment hospitalized Patients ARDS. A better understanding long-term effects how they might contribute Long COVID individuals is urgently needed.

Language: Английский

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Handwashing and Obsessive-Compulsive Disorder During COVID-19 Concerning Increased Negative Mental Health

Journal of Mental Health Disorders, Journal Year: 2023, Volume and Issue: 3(1), P. 18 - 30

Published: Dec. 18, 2023

COVID-19 has been identified as a virus spread to the respiratory system by minute airborne particles. This method of dispersion is in contrast its originally anticipated large particle fomite transmission. Although dissemination found be airborne, continuous health directive limit contagion during pandemic was improve handwashing. Persistent handwashing may aggravate obsessive-compulsive disorder (OCD), diminishing mental health. With modest value controlling COVID-19, determining if increased incidence OCD, promoting negative health, pertinent. A limited review parameter “handwashing, OCD” searched six relevant databases. The result that related evident both for those already diagnosed with OCD and regarding new cases throughout duration pandemic. exception very few patients demonstrating resilience or on stable medication. conclusion officials are advised update details their directives information becomes available Concerning concentrate should have modified once it known transmission improbable, doing so would reduced improved experiencing OCD. Regarding further research indicated medication under conditions when hand-washing advised.

Language: Английский

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Book review

Travel Medicine and Infectious Disease, Journal Year: 2023, Volume and Issue: 55, P. 102635 - 102635

Published: Aug. 26, 2023

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Additional file 1 of Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization

Figshare, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 1, 2023

Additional file 1. Correlation of chronological age with DNA methylation using Horvath, Hannum, SkinandBlood, PhenoAge, and GrimAge clocks the methylation-based telomere length (TL) estimator.

Language: Английский

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