Hesperidin alleviates kidney injury induced by nano-copper through regulating endoplasmic reticulum stress and autophagy via AMPK-AKT/mTOR pathway in broiler chicken

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105980 - 105980

Published: Jan. 1, 2025

Language: Английский

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Nutritional evaluation and antioxidant potential of pekmez from saffron processing by-products

LWT, Journal Year: 2025, Volume and Issue: unknown, P. 117615 - 117615

Published: March 1, 2025

Language: Английский

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Associations of long-term exposure to PM2.5 and its constituents with children renal function: a national retrospective study in China

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121607 - 121607

Published: April 1, 2025

Language: Английский

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The Dark Triad of Particulate Matter, Oxidative Stress and Coronary Artery Disease: What About the Antioxidant Therapeutic Potential

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 572 - 572

Published: May 9, 2025

Particulate matter (PM) is a complex mixture of particles with different adverse effects on health, especially the cardiovascular (CV) risk and disease (e.g., increased total CV mortality, ischemic heart disease, failure, stroke, hypertension, dyslipidemia type 2 diabetes). Since oxidative stress (OS) inflammation are main key mechanisms by which PM exerted its biological several inflammatory-related biomarkers have been measured associated PM; abnormalities in these parameters relation to highlight role this relationship terms health effects, including conditions. Antioxidant strategies might prevent/reverse, almost partly, related exposure, addressing OS inflammation, although clinical gain interventional tools not yet clearly demonstrated. This review aims summarize source composition, discussing inflammatory events environmental exposure as mechanistic determinants acute event precipitation. Moreover, modifying potential antioxidants, subjects more susceptible air pollution and/or highly exposed, will be discussed promising research area beyond conventional actually available prevent harmful reduction sources population assessment quality standards) order better face dark triad composed PM, disease.

Language: Английский

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Attenuation of PM2.5-Induced Lung Injury by 4-Phenylbutyric Acid: Maintenance of [Ca2+]i Stability between Endoplasmic Reticulum and Mitochondria

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1135 - 1135

Published: Sept. 8, 2024

Fine particulate matter (PM2.5) is a significant cause of respiratory diseases and associated cellular damage. The mechanisms behind this damage have not been fully explained. This study investigated two types (inflammation pyroptosis) induced by PM2.5, focusing on their relationship with organelles (the endoplasmic reticulum mitochondria). Animal models demonstrated that PM2.5 induces excessive stress (ER stress), which lung in rats. was confirmed pretreatment an ER inhibitor (4-Phenylbutyric acid, 4-PBA). We found that, vitro, the intracellular Ca2+ ([Ca2+]i) dysregulation rat alveolar macrophages stress. Changes mitochondria-associated membranes (MAMs) result abnormal mitochondrial function. further massive expression NLRP3 GSDMD-N, detrimental to cell survival. In conclusion, our findings provide valuable insights into between [Ca2+]i dysregulation, damage, inflammation pyroptosis under PM2.5-induced conditions. Their interactions ultimately impact health.

Language: Английский

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Metformin attenuates PM _2.5 -induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells

Toxicology Mechanisms and Methods, Journal Year: 2024, Volume and Issue: 34(9), P. 1022 - 1034

Published: July 22, 2024

The harmful effects of PM

Language: Английский

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Nutritional Evaluation and Antioxidant Potential of Pekmez a By-Product of Saffron Processing

Published: Jan. 1, 2024

Language: Английский

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