Restoration of vascular dysfunction resulting from maternal high-fat diet via modulation of the NLRP3/IL-1β axis DOI Creative Commons
Yuxuan Xiao, Xiaoning Bi, Rongjie Zhang

et al.

Clinical and Experimental Hypertension, Journal Year: 2024, Volume and Issue: 47(1)

Published: Dec. 26, 2024

This study investigated the impact of maternal high-fat diet on vascular function and endothelial homeostasis in offspring. We found that offspring exposed to exhibited elevated blood pressure, impaired abdominal aortic function, imbalance. These changes were accompanied by increased levels reactive oxygen species (ROS) upregulation pro-inflammatory cytokines (including IL-1β, TNF-α, IL-6, IL-10). Treatment with NLRP3 or IL-1β inhibitors prevented deterioration reduced NO production, inflammation induced exposure compared control group. The findings suggest during pregnancy, mitigating impairments can be achieved inhibiting NLRP3/IL-1β pathway.

Language: Английский

Indole-3-Carboxaldehyde Alleviates LPS-Induced Intestinal Inflammation by Inhibiting ROS Production and NLRP3 Inflammasome Activation DOI Creative Commons
Ji Cao,

Qiuyu Bao,

Haiping Hao

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1107 - 1107

Published: Sept. 13, 2024

Indole-3-carboxaldehyde (IAld) is a tryptophan (Trp) metabolite derived from gut microbiota, which has potential protective effect on intestinal inflammatory diseases. Abnormal activation of NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome an important cause inflammation. However, the and mechanism IAld NLRP3 remain unclear. Here, we found that inhibited in epithelial cells, effectively prevented barrier injury caused by lipopolysaccharide (LPS) stimulation. Mechanistically, demonstrated activated aryl hydrocarbon (AhR), subsequently reactive oxygen species (ROS) production, maintained mitochondrial membrane potential, blocked NF-κB/NLRP3 pathway cells. Also, AhR-specific inhibitor CH-223191 IAld-induced inhibition repairment. In addition, vivo results showed pro-inflammatory mediator production damage LPS-induced mice, related to AhR inhibition. Collectively, our study unveiled effective endogenous antioxidant suggested as treatment target for NLRP3-induced

Language: Английский

Citations

2
Restoration of vascular dysfunction resulting from maternal high-fat diet via modulation of the NLRP3/IL-1β axis DOI Creative Commons
Yuxuan Xiao, Xiaoning Bi, Rongjie Zhang

et al.

Clinical and Experimental Hypertension, Journal Year: 2024, Volume and Issue: 47(1)

Published: Dec. 26, 2024

This study investigated the impact of maternal high-fat diet on vascular function and endothelial homeostasis in offspring. We found that offspring exposed to exhibited elevated blood pressure, impaired abdominal aortic function, imbalance. These changes were accompanied by increased levels reactive oxygen species (ROS) upregulation pro-inflammatory cytokines (including IL-1β, TNF-α, IL-6, IL-10). Treatment with NLRP3 or IL-1β inhibitors prevented deterioration reduced NO production, inflammation induced exposure compared control group. The findings suggest during pregnancy, mitigating impairments can be achieved inhibiting NLRP3/IL-1β pathway.

Language: Английский

Citations

2