Mercuric chloride induced reproductive toxicity associated with oxidative damage in male Wistar albino rat, Rattus norvegicus DOI

M P Sampada,

Muniswamy David

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Language: Английский

Hydrogen sulfide alleviates cadmium stress in germinating carrot seeds by promoting the accumulation of proline DOI
Miao Sun,

Huan-Xuan Qiao,

Tao Yang

et al.

Journal of Plant Physiology, Journal Year: 2024, Volume and Issue: 303, P. 154357 - 154357

Published: Sept. 19, 2024

Language: Английский

Citations

4
Dietary silicate minerals relieving cadmium or lead poisoning in juvenile sea cucumber, Apostichopus japonicus DOI
Yi‐Ping Phoebe Chen,

Shuchang Cui,

Lin Wu

et al.

Marine Environmental Research, Journal Year: 2024, Volume and Issue: 202, P. 106795 - 106795

Published: Oct. 19, 2024

Language: Английский

Citations

4
Dietary selenium mitigates cadmium-induced apoptosis and inflammation in chicken testicles by inhibiting oxidative stress through the activation of the Nrf2/HO-1 signaling pathway DOI Creative Commons
Yulong Li, Shu Wang, Rui Feng

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: 104(4), P. 104990 - 104990

Published: March 8, 2025

Cadmium (Cd) is a non-essential heavy metal that highly toxic to testicle. Selenium (Se) known possess antagonistic effects against Cd toxicity, yet the precise mechanisms through which Se counteracts Cd-induced testicular damage in chickens Nuclear factor erythroid 2-related 2/Heme oxygenase-1 (Nrf2/HO-1) signaling pathway, oxidative stress (OS), apoptosis, and inflammation remained unclear. In present study, experimental model of chicken testis was established by incorporating CdCl2 Na2SeO3 into dietary intake. After 60 days, from each group were euthanized, serum samples subsequently collected. Ultrastructural assessment revealed supplementation significantly mitigated induced Cd. effectively suppressed elevation ROS, MDA, H2O2 levels, while also preventing downregulation CAT, GSH, T-AOC levels. Furthermore, administration ameliorated reduction expression levels Nrf2, HO-1, Bcl-2 Cd, counteracted overexpression Caspase-3, Bax, Cyt-c, Caspase-9, TNF-α, IL-2, IL-6, IL-1β. Meanwhile, immunofluorescence data demonstrated attenuated decrease Nrf2 HO-1 upregulation IL-6 expression. conclusion, this study elucidated might mitigate testicles stimulation Nrf2/HO-1 thereby inhibiting apoptosis inflammation, beneficial reducing injury.

Language: Английский

Citations

0
Fly Ash-Induced Groundwater Contamination and Magnetic Nanoparticles as an Innovative Adsorbent for Remediation: A critical review DOI Creative Commons

Alan Boche,

S.J. Dhoble,

Shamli S. Gupte

et al.

Hybrid Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100461 - 100461

Published: March 1, 2025

Language: Английский

Citations

0
Deoxynivalenol exposure-related male reproductive toxicity in mammals: Molecular mechanisms, detoxification and future directions DOI Creative Commons
Chongshan Dai, Zhihui Hao,

Dingkuo Liu

et al.

Environment International, Journal Year: 2025, Volume and Issue: 199, P. 109478 - 109478

Published: April 17, 2025

An increasing body of evidence indicates that exposure to widespread, environmental and food contaminants such as mycotoxins may cause endocrine disorders infertility. Deoxynivalenol (DON), which is a toxic secondary metabolite produced by Fusarium fungi, can lead multiple harmful effects in humans animals, hepatotoxicity, nephrotoxicity, immunotoxicity, gastrointestinal toxicity, neurotoxicity, genetic toxicity carcinogenicity. Recently, there has been growing concern about DON-induced male Exposure DON its metabolites damage the structure function reproductive organs, resulting impairment gametogenesis thus impaired fertility. Potential molecular mechanisms involve oxidative stress, inflammatory response, mitochondrial dysfunction, apoptosis, cell cycle arrest, pyroptosis, ferroptosis. Moreover, several signaling pathways, including nuclear factor-kappa B, mitogen-activated protein kinase, NLR family pyrin domain containing 3, factor erythroid 2-related 2, AMP-activated apoptotic microRNAs are involved these detrimental biological processes. Research shown antioxidants, small-molecule inhibitors, or proteins (such lactoferrin) supplementation potentially offer protective targeting pathways. This review comprehensively summarizes on mammals, underlying emphasizes potential small molecules therapeutics. In further, systematic risk assessment when at doses human health, in-depth precise mechanism investigation using emerging technologies, development more effective intervention strategies warrant urgent investigation.

Language: Английский

Citations

0
Impact of oxidative stress induced by heavy metals on ovarian function DOI Creative Commons
Chengqi Xiao, Dongmei Lai

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: June 28, 2024

As a crucial organ of the female reproductive system, ovary has both and endocrine functions. Oxidative stress refers to an increase in intracellular reactive oxygen species (ROS), which play role normal physiological activity ovary. However, excessive ROS can cause damage With advancement human industrial activities, heavy metal pollution become increasingly severe. Heavy metals oxidative through direct indirect mechanisms, leading changes signal transduction pathways that ovaries. This review aims outline adverse effects on ovaries triggered by such as copper, arsenic, cadmium, mercury, lead. The detrimental include follicular atresia decreased estrogen production experimental animals, they also premature ovarian insufficiency women. Additionally, this discusses antioxidants, provides some treatment methods, summarizes limitations current research, offers perspectives for future research directions.

Language: Английский

Citations

2
Aflatoxin Exposure-Caused Male Reproductive Toxicity: Molecular Mechanisms, Detoxification, and Future Directions DOI Creative Commons

Dongyun Ye,

Zhihui Hao,

Shusheng Tang

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1460 - 1460

Published: Nov. 17, 2024

Widespread endocrine disorders and infertility caused by environmental food pollutants have drawn considerable global attention. Aflatoxins (AFTs), a prominent class of mycotoxins, are recognized as one the key contributors to contamination. Aflatoxin B

Language: Английский

Citations

2
Salidroside Prevents Cadmium Chloride-Induced DNA Damage in Human Fetal Lung Fibroblasts DOI
Yufei Wu,

Chuan Sun

Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 86, P. 127521 - 127521

Published: Sept. 6, 2024

Language: Английский

Citations

1
Cadmium Exposure Induces Inflammation Through Oxidative Stress-Mediated Activation of the NF-κB Signaling Pathway and Causes Heat Shock Response in a Piglet Testis DOI
Yulong Li, Hongbao Wang, Yanfei Wang

et al.

Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Language: Английский

Citations

1
Dysregulation of Long Non-coding RNAs—the Novel lnc in Metal Toxicity and Carcinogenesis DOI
Zhishan Wang, Po‐Shun Wang, Chengfeng Yang

et al.

Current Environmental Health Reports, Journal Year: 2024, Volume and Issue: 12(1)

Published: Dec. 23, 2024

Language: Английский

Citations

0