Nuclear receptor coactive 4-mediated ferritinophagy: a key role of heavy metals toxicity

Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Language: Английский

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Senescent endothelial cell-derived Galectin 3 promotes silicosis through endothelial-fibroblast and endothelial-macrophage crosstalk

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137605 - 137605

Published: Feb. 13, 2025

Language: Английский

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Puerarin alleviates silicon dioxide-induced pulmonary inflammation and fibrosis via improving Autophagolysosomal dysfunction in alveolar macrophages of murine mice

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114375 - 114375

Published: March 4, 2025

Language: Английский

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Current Status and Prospects of the Pathological Mechanisms and Therapeutic Drugs for Silicosis

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(04), P. 518 - 530

Published: Jan. 1, 2025

Language: Английский

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Protein Ubiquitination Modification in Pulmonary Fibrosis

Comprehensive physiology, Journal Year: 2025, Volume and Issue: 15(3)

Published: May 1, 2025

Pulmonary fibrosis (PF) is a chronic, progressive fibrotic interstitial lung disease characterized by high incidence and mortality rate, which encompasses features, such as diffuse alveolar inflammation, invasive fibroblast activation, uncontrolled extracellular matrix (ECM) deposition. Beyond the local pathological processes, PF can be better understood in light of interorgan communication networks that are involved its progression. Notably, pulmonary inflammation affect cardiovascular, renal, hepatic, neural functions, highlighting importance understanding these systemic interactions. Posttranslational modifications play crucial role regulating protein function, localization, stability, activity. Specifically, ubiquitination induced various stimuli, involving range ubiquitin-modifying enzymes substrates. In this review, we provide an overview how E3 ubiquitin ligases deubiquitinating (DUBs) modulate through several signaling pathways, TGF-β, Wnt, metabolic activity, aging, ferroptosis, endoplasmic reticulum stress, inflammatory responses. This perspective includes ubiquitin-proteasome systems communication, affecting progression related conditions. Additionally, also summarize currently available therapeutic compounds targeting ubiquitination-related or substrates for treatment PF. Understanding interplay between may pave way novel strategies.

Language: Английский

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Pulmonary fibrosis: from mechanisms to therapies

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 8, 2025

Pulmonary fibrosis (PF) is a chronic, progressive interstitial lung disease characterized by excessive deposition of extracellular matrix (ECM) and abnormal fibroblast proliferation, which mainly caused air pollution, smoking, aging, occupational exposure, environmental pollutants microbial infections. Although antifibrotic agents such as pirfenidone nintedanib, approved the United States (US) Food Drug Administration (FDA), can slow decline in function progression, their side effects delivery inefficiency limit overall prognosis PF. Therefore, there an urgent need to develop effective therapeutic targets approaches for PF clinical settings. This review provides overview pathogenic mechanisms, drug targeting signaling pathways, promising strategies treating

Language: Английский

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Endothelial-to-mesenchymal transition in cardiovascular diseases

Trends in Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: June 1, 2025

Language: Английский

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