Emerging Trends in Snake Venom-Loaded Nanobiosystems for Advanced Medical Applications: A Comprehensive Overview

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 204 - 204

Published: Feb. 6, 2025

Advances in medical nanobiotechnology have notably enhanced the application of snake venom toxins, facilitating development new therapies with animal-derived toxins. The vast diversity species and their complexities underline need for ongoing research. This review is dedicated to exploring integration nanoparticles enable use human aiming develop treatments. complex mixture not only inflicts significant pathological effects but also offers valuable insights creation innovative therapies, particularly realm nanobiotechnology. Nanoscale encapsulation mitigates inherent toxicity amplifies antitumoral, antimicrobial, immunomodulatory properties. synergy between venom-derived macromolecules nanotechnology a novel pathway augmenting efficacy safety conventional antivenom extending applicability beyond treating bites potentially addressing myriad health issues. In conclusion, presents compelling therapeutic frontier that promises improve current treatment modalities ameliorate adverse associated venomous snakebites.

Language: Английский

Effect of Seaweed-Derived Fucoidans from Undaria pinnatifida and Fucus vesiculosus on Coagulant, Proteolytic, and Phospholipase A2 Activities of Snake Bothrops jararaca, B. jararacussu, and B. neuwiedi Venom

Toxins, Journal Year: 2024, Volume and Issue: 16(4), P. 188 - 188

Published: April 12, 2024

Background: Snakebite envenomation (SBE) causes diverse toxic effects in humans, including disability and death. Current antivenom therapies effectively prevent death but fail to block local tissue damage, leading an increase the severity of envenomation; thus, seeking alternative treatments is crucial. Methods: This study analyzed potential two fucoidan sulfated polysaccharides extracted from brown seaweeds Fucus vesiculosus (FVF) Undaria pinnatifida (UPF) against fibrinogen or plasma coagulation, proteolytic, phospholipase A2 (PLA2) activities Bothrops jararaca, B. jararacussu, neuwiedi venom. The toxicity FVF UPF was assessed by hemocompatibility test. Results: did not lyse human red blood cells. inhibited proteolytic activity venom approximately 25%, 50%, 75%, respectively, while all venoms led a 20% inhibition PLA2 activity. delayed coagulation caused jararaca affect jararacussu blocked induced these Bothropic venoms. Conclusion: may be importance as adjuvants for SBE species Bothrops, which are most medically relevant snakebite incidents South America, especially Brazil.

Language: Английский

Snakebite-induced reversible cerebral vasoconstriction syndrome: report of three cases

Toxicon, Journal Year: 2024, Volume and Issue: 251, P. 108161 - 108161

Published: Nov. 1, 2024

Language: Английский