Novel insights on the probable mechanism associated with histamine oral model‐inducing neuropathological and behavioral toxicity in rats

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(2)

Published: Jan. 21, 2024

Abstract Histamine (HIS) is an important chemical mediator that causes vasodilation and contributes to anaphylactic reactions. Recently, HIS understudied neurotransmitter in the central nervous system, its potential role neuroinflammation neurodegeneration a critical area of research. So, study's goal investigate consequences repeated oral intake on rat's brain explore mechanistic way neurotoxicity. Thirty male rats were divided into three groups ( n = 10). The following treatments administered orally all every day for 14 days. Group (1) was given distilled water, whereas (2 & 3) at dosage levels 250 500 mg/kg body weight (BWT), respectively. Brain tissue samples collected 7‐ 14‐days from beginning experiment. Our results revealed continuous administration both doses days significantly reduced BWT induced severe neurobehavioral changes, including depression, dullness, lethargy, tremors, abnormal walking, loss spatial learning memory rats. In receiving groups, HPLC data showed considerable raise contents brain. Additionally, daily consumption oxidative stress dose‐ time‐dependent which characterized by elevation malondialdehyde along with reduction catalase activity glutathione levels. neuropathological lesions commonly observed cerebrum, striatum, cerebellum confirmed immunohistochemistry staining demonstrating moderate strong caspase‐3 inducible nitric oxide synthase expressions mainly those HIS. NF‐κB, TNF‐α, IL‐1β gene also upregulated particularly getting mg/kg. We concluded ROS‐induced apoptosis inflammation essential mechanism involved HIS‐mediated toxicity histopathology.

Language: Английский

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Comorbidity of Histamine Intolerance and Polyvalent Allergy: A Case Report and Literature Review

Healthcare, Journal Year: 2025, Volume and Issue: 13(2), P. 94 - 94

Published: Jan. 7, 2025

Background/Objectives: Histamine intolerance is becoming a critical medical problem across numerous clinical specialties, due to the absence of standardized diagnostic and therapeutic strategy manage patients with suspicion or diagnosis this condition. type non-immune food hypersensitivity, characterized by heterogenous etiologies very broad range symptoms. The condition result an imbalance between amount histamine accumulated within body body's systemic ability degrade it. In regard diagnostics intolerance, need preliminarily exclude other potential conditions associated increased levels in blood has been highlighted. co-occurrence allergies not uncommon, similarity manifestations can lead diagnostic, as well therapeutic, difficulties. This paper details workflow for patient polyvalent allergy comorbidity, aim being help outline protocol that may be helpful clinicians managing intolerance. Case Presentation: article presents case 30-year-old multimorbidity (allergic rhinitis, asthma, allergy, eosinophilic esophagitis), comorbid Due violent severe symptoms, including facial erythema, urticaria, pruritus, abdominal pain, tachycardia, experienced after meals, received intramuscular epinephrine injections three times week. course management are presented. Conclusions: difficult high variability heterogeneity symptoms individual patients. Many studies on issue recommend ruling out allergic background terms complaint. However, possibility IgE-dependent overlapping those should taken into account every case. particularly important presenting atypical diseases. presented herein daily practice allergologists physicians example both non-allergic backgrounds.

Language: Английский

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Emerging challenges in aquaculture: Current perspectives and human health implications

Veterinary World, Journal Year: 2025, Volume and Issue: unknown, P. 15 - 28

Published: Jan. 1, 2025

Aquaculture, the cultivation of aquatic organisms for human consumption, has become an essential contributor to global food security. However, it faces numerous challenges that threaten its sustainability and capacity meet growing demand animal protein. This review investigates these challenges, with a particular focus on environmental degradation, public health risks, ethical dilemmas posed by genetic interventions in fish breeding. Despite promise genetically modified (GMOs) enhancing production, their integration into aquaculture remains controversial due potential risks unresolved questions. study aims provide comprehensive understanding pressing issues propose pathways sustainable development. With population increasing protein intensifying, holds great as source. contribution minimal, projected decline low 4% coming decades. Furthermore, aquaculture's impact, including pollution water bodies ecosystem disruption, poses serious threats biodiversity health. Addressing is critical ensuring long-term viability aquaculture. By exploring intersection sustainability, ethics, innovation, this provides valuable insights policymakers, industry stakeholders, researchers seeking advance practices. evaluate current state identify key related health, considerations. It seeks explore practices address while balancing need increased production societal acceptance. The ultimate goal offer practical recommendations fostering resilient capable meeting future demands.

Language: Английский

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Formation of urocanic acid versus histamine from histidine in chub mackerel (Scomber japonicus) fillets as determined by a mixed-mode HPLC method

Journal of Food Composition and Analysis, Journal Year: 2025, Volume and Issue: 142, P. 107431 - 107431

Published: Feb. 28, 2025

Language: Английский

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A critical review on biogenic amines in dairy: Formation pathways, toxicity, and regulatory standards

Journal of Food Composition and Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 107496 - 107496

Published: March 1, 2025

Language: Английский

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An allergist's approach to food poisoning

Annals of Allergy Asthma & Immunology, Journal Year: 2022, Volume and Issue: 130(4), P. 444 - 451

Published: Nov. 2, 2022

Language: Английский

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Effects of selected Bacillus strains on the biogenic amines, bioactive ingredients and antioxidant capacity of shuidouchi

International Journal of Food Microbiology, Journal Year: 2023, Volume and Issue: 388, P. 110084 - 110084

Published: Jan. 11, 2023

Language: Английский

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High-Resolution Comparative and Quantitative Proteomics of Biogenic-Amine-Producing Bacteria and Virulence Factors Present in Seafood

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(8), P. 4448 - 4463

Published: Feb. 16, 2024

The presence of biogenic amines (histamine, tyramine, putrescine, and cadaverine) in seafood is a significant concern for food safety. This review describes the first time shotgun quantitative proteomics strategy to evaluate compare foodborne strains bacteria that produce seafoods. approach recognized 35,621 peptide spectrum matches, belonging 20,792 peptides, 4621 proteins. It allowed determination functional pathways classification into hierarchical clusters. study identified protein–protein interaction network involving 1160 nodes/10,318 edges. Proteins were related energy pathways, spermidine biosynthesis, putrescine metabolism. Label-free identification differentially regulated proteins specific such as aminotransferase, arginine decarboxylase, l-histidine-binding protein. Additionally, 123 peptides characterized virulence factors 299 biomarkers selected identify bacterial species fish products. presents most extensive proteomic repository progress science could be applied industry detection contamination produces histamine other during processing/storage.

Language: Английский

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The Relationship of Histamine Content in European Pilchard (Sardina pilchardus) with Freshness, Temperature, and Storage Duration

World s Veterinary Journal, Journal Year: 2024, Volume and Issue: unknown, P. 66 - 73

Published: March 25, 2024

Histamine food poisoning, stemming from the consumption of certain histamine-rich fish species, such as tuna, mackerel, European pilchards, and herring, is one major public health issues worldwide. The present study aimed to evaluate histamine content in fresh pilchard (Sardina pilchardus Walbaum, 1792) Mehdia, a coastal city north Morocco. Three randomly selected batches each weighing 20kg, were obtained different boats upon landing. evolution production was monitored every 8 hours for 6 days, with batch stored at 0°C other 10°C. organoleptic characteristics examined considering sensory evaluation according rating system Council Regulation No. 2406/96 common marketing standards fishery products quality index method (QIM). flesh determined using fluorometric method. results indicated that average did not exceed 5 ppm during storage 0°C. freshness ratings highest first 3 corresponding QIM values 0 10 On days 4 5, on A, 11 12, last day, they B, value 15 preservation quality. Statistically, significant correlation found between pilchard’s duration. In contrast, this duration insignificant. At 10°C, exceeded regulatory limit force (100 ppm) after 32 storage, spoilage occurred day 3. Statistical analysis revealed strong content, temperature, degree freshness, storage. extra guarantees very large margin safety regarding can be consumed without risk. Keywords: Degree pilchard, Histamine, Sardine, Storage, Temperature

Language: Английский

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Survival, growth, and biogenic amine production of Enterococcus faecium FC12 in response to extracts and essential oils of Rubus fruticosus and Juniperus oxycedrus

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 9

Published: Jan. 13, 2023

Enterococci are lactic acid bacteria (LAB) usually found as food contaminants in fermented products such cheeses and sausages. Due to their antibiotic resistance, the presence of virulence factors, ability produce biogenic amines (BAs), determination these is crucial assure quality safety. BAs production consequent accumulation foods can cause toxicological effects on human health. Plant phenolic compounds promising alternatives chemical preservatives reflect consumers' demand for "green" solutions. In this study, antimicrobial effect blackberry (Rubus fruticosus) leaves prickly juniper (Juniperus oxycedrus) needles, both extracts (PE) essential oils (EO), were evaluated against Enterococcus faecium FC12, a known tyramine-producing strain.The growth kinetics sub-lethal concentrations plant derivatives modeled (Gompertz equation) BA was monitored over time by HPLC. Moreover, flow cytometry (FCM) used study EOs PEs cell viability.The showed higher (especially R. fruticosus added at 0.75 mg/ml), determining an initial decrease culturable cells followed recovery, even if with lower rates final loads. Different formation observed, tyramine ranging from 120 160 mg/l after 96 h incubation, 2-phenylethylamine produced amounts, reaching peak tyramine. FCM confirmed efficacy EO that induced membrane injury 93% total population. However, complete recovery occurred following demonstrating transient damage.Although further research required better investigate assess suitability approach real system, present potential activity derivatives, especially EO, E. FC12.

Language: Английский

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