Aristolochic Acid Nephropathy: Molecular Mechanisms, Clinical Impact and Therapeutic Challenges in a Progressive Renal Disease DOI Creative Commons
Juan José Nuñez Calle,

Christian Anthony Laso-Barrera,

Jhomayra Michelle Segovia-Valdiviezo

et al.

Iberoamerican Journal of Medicine, Journal Year: 2025, Volume and Issue: 7(2), P. 53 - 63

Published: April 15, 2025

Aristolochic acid nephropathy (AAN) is a rapidly progressive form of interstitial nephritis associated with the use medicinal plants from Aristolochiaceae family, which contain aristolochic (AA) and environmental pollutants. It was first discovered in Belgium 1990s renal fibrosis high risk urothelial carcinoma. Development discussion: AAN toxic kidney disease consumption AA or contaminated food. characterized by nephritis, an increased Its pathogenesis includes mitochondrial DNA damage, TP53 mutations, inflammation fibrosis. Clinically, presents as chronic forms, acute damage after massive ingestion mild tubular dysfunction. Diagnosis based on history exposure, clinical findings, biopsy urinary biomarkers. Complications include carcinoma, severe end-stage disease. Treatment requires elimination oncologic surveillance, advanced support. This emphasizes need for targeted therapies to slow progression improve prognosis. multifactorial impact morbidity. Prevention, early diagnosis multidisciplinary management are crucial prognosis quality life patients.

Language: Английский

Aristolochic Acid Nephropathy: Molecular Mechanisms, Clinical Impact and Therapeutic Challenges in a Progressive Renal Disease DOI Creative Commons
Juan José Nuñez Calle,

Christian Anthony Laso-Barrera,

Jhomayra Michelle Segovia-Valdiviezo

et al.

Iberoamerican Journal of Medicine, Journal Year: 2025, Volume and Issue: 7(2), P. 53 - 63

Published: April 15, 2025

Aristolochic acid nephropathy (AAN) is a rapidly progressive form of interstitial nephritis associated with the use medicinal plants from Aristolochiaceae family, which contain aristolochic (AA) and environmental pollutants. It was first discovered in Belgium 1990s renal fibrosis high risk urothelial carcinoma. Development discussion: AAN toxic kidney disease consumption AA or contaminated food. characterized by nephritis, an increased Its pathogenesis includes mitochondrial DNA damage, TP53 mutations, inflammation fibrosis. Clinically, presents as chronic forms, acute damage after massive ingestion mild tubular dysfunction. Diagnosis based on history exposure, clinical findings, biopsy urinary biomarkers. Complications include carcinoma, severe end-stage disease. Treatment requires elimination oncologic surveillance, advanced support. This emphasizes need for targeted therapies to slow progression improve prognosis. multifactorial impact morbidity. Prevention, early diagnosis multidisciplinary management are crucial prognosis quality life patients.

Language: Английский

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