Role of Gallic Acid in Counteracting Depleted Uranium–Induced Renal Toxicity in Rats: Participation of Redox Stabilizers, Nrf2, NF‐Kb, and Caspase‐3

Journal of Food Biochemistry, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Uranyl acetate (UA), a form of depleted uranium (DU) extensively applied for military and civilian purposes, poses health threat to exposed populations. Gallic acid (GA), phytochemical present in various edible sources, has the potential restore redox balance exhibit anti‐inflammatory antiapoptotic effects. Thus, we highlighted protective role GA mitigating UA‐induced renal cytofunctional impairments rats. To achieve this objective, rats were randomly divided into three groups. The first group was left untreated served as control. second (UA group) administered single intraperitoneal injection UA at dose 5 mg/kg body weight. third (GA + UA) orally administrated via gastric tube 20 weight 14 days prior injection. In both groups, on 15th day, euthanized 17th day experiment. At end experiment, plasma damage biomarkers, parameters, histopathological examination estimated, along with immunohistochemical analysis caspase‐3, nuclear factor kappa B (NF‐kB), erythroid 2‐related 2 (Nrf2). Our findings indicated that supplementation UA‐intoxicated reduced urea creatinine levels while increased total antioxidant capacity. It also restored normal kidney superoxide dismutase, catalase, glutathione, nitric oxide. Additionally, it glycogen reserves decreased collagen fiber deposition. group, immunoreaction caspase‐3 NF‐kB decreased, those Nrf2 increased. summary, mitigate DU‐associated nephrotoxicity by enhancing defense mechanism, well modulating protein expression related cell death pathways proinflammatory transcription factors.

Language: Английский

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Impact of Graphene Derivatives as Artificial Extracellular Matrices on Mesenchymal Stem Cells

Molecules, Journal Year: 2022, Volume and Issue: 27(2), P. 379 - 379

Published: Jan. 7, 2022

Thanks to stem cells’ capability differentiate into multiple cell types, damaged human tissues and organs can be rapidly well-repaired. Therefore, their applicability in the emerging field of regenerative medicine further expanded, serving as a promising multifunctional tool for tissue engineering, treatments various diseases, other biomedical applications well. However, differentiation survival cells specific lineages is crucial exclusively controlled. In this frame, growth factors chemical agents are utilized stimulate adjust proliferation cells, although challenges related with degradation, side effects, high cost should overcome. Owing unique physicochemical biological properties, graphene-based nanomaterials have been widely used scaffolds manipulate potential. Herein, we provide most recent research progress mesenchymal (MSCs) growth, function utilizing graphene derivatives extracellular scaffolds. The interaction rat MSCs has also evaluated. Graphene-based biocompatible, exhibiting great potential stem-cell-mediated they may promote behaviour control cells. Finally, challenges, prospects future trends discussed.

Language: Английский

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Gallic acid rescues uranyl acetate induced-hepatic dysfunction in rats by its antioxidant and cytoprotective potentials

BMC Complementary Medicine and Therapies, Journal Year: 2023, Volume and Issue: 23(1)

Published: Nov. 22, 2023

The liver was identified as a primary target organ for the chemo-radiological effects of uranyl acetate (UA). Although anti-oxidant and anti-apoptotic properties gallic acid (GA) make it promising phytochemical to resist its hazards, there is no available data in this area research.To address issue, eighteen rats were randomly equally divided into three groups. One group received carboxymethyl cellulose (vehicle GA) kept control. UA injected intraperitoneally with at single dose 5 mg/kg body weight. third (GA + group) treated GA orally 100 weight 14 days before exposure. on 15th day experiment either or group. biochemical, histological, immunohistochemical findings compared both control groups.The results showed that exposure led range adverse effects. These included elevated plasma levels aspartate aminotransferase, lactate dehydrogenase, total protein, globulin, glucose, cholesterol, triglycerides, low-density lipoprotein very-low-density decreased high-density cholesterol. also disrupted redox balance, evident through antioxidant capacity hepatic nitric oxide, superoxide dismutase, reduced glutathione, glutathione-S-transferase, glutathione reductase, peroxidase increased oxidized malondialdehyde. Plasma albumin alanine aminotransferase did not significantly change all Histopathological analysis revealed damage tissue, characterized by deteriorations tissue structure, excessive collagen accumulation, depletion glycogen. Furthermore, up-regulated immuno-expression cleaved caspase-3 down-regulated nuclear factor-erythroid-2-related factor 2 tissues, indicating an induction apoptosis oxidative stress response. However, pre-treatment proved be effective mitigating these negative induced exposure, except disturbances lipid profile.The study suggests has potential act protective agent against liver. Its ability restore balance inhibit makes candidate countering harmful agents such UA.

Language: Английский

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Al2O3 nanoparticles trigger the embryonic hepatotoxic response and potentiate TNF-α-induced apoptosis—modulatory effect of p38 MAPK and JNK inhibitors

Environmental Science and Pollution Research, Journal Year: 2022, Volume and Issue: 29(36), P. 54250 - 54263

Published: March 17, 2022

Language: Английский

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Monoamine Oxidases and Flavin-Containing Monooxygenases

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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Rehabilitation of N, N'-methylenebisacrylamide-induced DNA destruction in the testis of adult rats by adipose-derived mesenchymal stem cells and conditional medium

Heliyon, Journal Year: 2024, Volume and Issue: 10(23), P. e40380 - e40380

Published: Nov. 14, 2024

Environmental pollutant acrylamide has toxic effect on human health. Numerous industries such as the paper, and cosmetics, use in their manufacturing. In certain foods, arises at extremely high temperatures. Mesenchymal stem cells can shield different tissues from damaging effects of free radicals induced by acrylamide. This study aimed to compare therapeutic efficacy against acrylamide-induced toxicity between adipose-derived mesenchymal (MSCs) conditioned media (CM), evaluating which is more effective. Seventy adult male rats were employed this study, distributed among 5 groups. The control group consisted 10 rats, while each other four groups comprised 15 rats. AC received a daily oral (AC) dosage 3 mg/kg. + AD-MSCs CM groups, after 4 weeks administration, injected with 0.65 ×

Language: Английский

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Neurotoxicity of Aluminum and Its Compound Nanoparticles

Published: Jan. 1, 2023

The rapid development of nanotechnology has led to the emergence new nanomaterials. Due their special physicochemical properties, such as smaller size, larger specific surface area, and higher reactivity, nanomaterials often exhibit distinct or even stronger toxic effects than micron-sized bulk counterparts. Aluminum its compound nanoparticles are one most abundant in world's nanoparticle market have been used a wide range applications daily life, industrial production, aerospace, biomedical, etc. At same time, it also concerns about health effects, especially neurotoxicity, caused by occupational non-occupational exposure aluminum nanoparticles. Current toxicological studies explored neurotoxicity establishing various animal models, including fish, nematodes, rodents, well multiple cellular models. actual scenarios simulated routes oral, inhalation, nasal drip, peripheral administration. In addition, potential mechanisms disruption brain-blood barrier, overproduction ROS, abnormal mitochondrial function, autophagy activation were confirmed be involved

Language: Английский

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Efficiency of Folic acid and Zinc chloride in ameliorating Arsenic-induced toxicity in salivary gland and taste buds of adult male albino rats

Egyptian Dental Journal /Egyptian Dental Journal, Journal Year: 2023, Volume and Issue: 69(4), P. 2681 - 2696

Published: Oct. 1, 2023

Background: Arsenic (As) in food and water can cause symptoms soft tissues of mouth.Zinc metal folic acid (a water-soluble B vitamin) act as antioxidants.Objective: Assessment the effects arsenic on submandibular salivary gland taste buds rats, how zinc chloride ameliorate these effects.Methodology: Twenty-five rats were divided equally into 5 groups: (C); without any treatments, (HCl); got a daily oral dose HCl for 15 days, (As); received 3 mg/kg b.w.orally As III days.(As + Fa) (As Zn) 0.1 2 Zncl2 respectively orally months after receiving III.Plasma IL-6, IL-10, NO, GSH measurements, Histological immunohistochemical (GLUT-1 cleaved caspase-3) examinations glands performed.Results: increased IL-6 NO levels decreased IL-10 significantly.Submandibular showed alterations apoptosis necrosis.Compared to control, collagen fibers, GLUT-1, caspase-3 significantly.Folic exposure raised GSH, appeared nearly normal.Salivary GLUT-1 immunoreaction, immunoreaction significantly versus group. Conclusion:Oxidative stress from damages via apoptosis, necrosis, inflammation.Folic minimize that damage.

Language: Английский

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Prevention of methylmercury-triggered ROS-mediated impairment of embryo development by co-culture with adult adipose-derived mesenchymal stem cells

Toxicology Research, Journal Year: 2023, Volume and Issue: 13(1)

Published: Dec. 27, 2023

Methylmercury (MeHg) is a potent toxin that exerts deleterious effects on human health via environmental contamination. Significant of MeHg neuronal development in embryogenesis have been reported. Recently, our group demonstrated toxic pre- and post-implantation embryonic processes from zygote to blastocyst stage. Our results showed impairs embryo by induction apoptosis through reactive oxygen species (ROS) generation triggers caspase-3 cleavage activation, which, turn, stimulates p21-activated kinase 2 (PAK2) activity. Importantly, ROS were identified as key upstream regulator apoptotic events MeHg-treated blastocysts. Data the current study further confirmed hazardous cell proliferation, apoptosis, implantation, development. Notably, MeHg-induced injury was markedly prevented co-culture with adipose-derived mesenchymal stem cells (ADMSCs) vitro. Furthermore, ADMSC injection significantly reduced MeHg-mediated embryo, placenta, fetal vivo. Further investigation regulatory mechanisms which co-cultured ADMSCs could prevent impairment revealed effectively its subsequent downstream events, including loss mitochondrial membrane potential activation PAK2. The collective findings indicate (MSCs) or utilization MSC-derived cell-conditioned medium offers an effective therapeutic strategy MeHg.

Language: Английский

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