A Review of Current Bacterial Resistance to Antibiotics in Food Animals

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: May 12, 2022

The overuse of antibiotics in food animals has led to the development bacterial resistance and widespread resistant bacteria world. Antibiotic-resistant (ARB) antibiotic-resistant genes (ARGs) are currently considered emerging contaminants, which a serious threat public health globally. current situation ARB ARGs from animal farms, manure, wastewater was firstly covered this review. Potential risks were also highlighted, as well strategies (including novel technologies, alternatives, administration) fight against resistance. This review can provide an avenue for further research, development, application antibacterial agents reduce adverse effects antibiotic farms.

Language: Английский

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MXene-based nanocomposites: emerging candidates for the removal of antibiotics, dyes, and heavy metal ions

Materials Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 7(22), P. 5519 - 5544

Published: Jan. 1, 2023

Fabrication of MXene-based nanocomposites. Photocatalytic properties membranes for the separation toxic pollutants, such as antibiotic drugs, dyes, etc . nanocomposites absorbents heavy metal removal.

Language: Английский

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Microplastic biofilm, associated pathogen and antimicrobial resistance dynamics through a wastewater treatment process incorporating a constructed wetland

Water Research, Journal Year: 2023, Volume and Issue: 235, P. 119936 - 119936

Published: April 3, 2023

Microplastics in wastewater are colonized by biofilms containing pathogens and antimicrobial resistance (AMR) genes that can be exported into receiving water bodies. This study investigated establishment changes microplastic-associated biofilm AMR during a conventional full-scale 2100 population equivalent treatment process combined with free surface polishing constructed wetland. Sequential microplastic colonization experiments were conducted at different stages of the process, including raw sewage, treated effluent Two scenarios tested which wetland served as either (i) step or (ii) primary recipient sewage inoculated microplastics. Bacterial 16S rRNA gene sequencing was carried out for qualitative bacterial community analysis. qPCR applied quantitative analysis (sul1, ermB, tetW, intiI1), biomass (16S rRNA) human fecal marker (HF183). Microbial diversity on microplastics increased incubation time. The initial sewage-derived composition changed more significantly compared to Pathogen load decreased up two orders magnitude after coupled treatment, while less impact observed when sewage-inoculated material directly transferred Aeromonas, Klebsiella, Streptococcus key pathogenic genera correlated biofilms. Despite decreasing trends along considerable potential hotspot (intI1 gene) accommodated Cyanobacteria fish pathogens.

Language: Английский

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Enhanced hepatotoxicity in zebrafish due to co-exposure of microplastics and sulfamethoxazole: Insights into ROS-mediated MAPK signaling pathway regulation

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 278, P. 116415 - 116415

Published: May 3, 2024

The combined pollution of microplastics (MPs) and sulfamethoxazole (SMZ) often occurs in aquatic ecosystems, posing a serious threat to animal human health. However, little is known about the liver damage caused by single or co-exposure MPs SMZ, its specific mechanisms are still poorly understood. In this study, we investigated effects 20 μm 80 nm SMZ both larval adult zebrafish models. Firstly, observed significant decrease number hepatocytes worsened following MPs. Additionally, macrophages neutrophils decreased, while expression inflammatory cytokines antioxidant enzyme activities increased after zebrafish. Transcriptome analysis revealed changes gene co-exposed groups, particularly processes related oxidation-reduction, response, MAPK signaling pathway Co-exposure also promoted hepatocyte apoptosis inhibited proliferation levels, which was associated with translocation Nrf2 from cytoplasm nucleus an increase protein levels NF-kB p65 Furthermore, our pharmacological experiments demonstrated that inhibiting ROS blocking partially rescued injury induced conclusion, findings suggest induces hepatic dysfunction through ROS-mediated This information provides novel insights into potential environmental risk hazardous pollutants co-existence ecosystems.

Language: Английский

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The Convergence of Antibiotic Contamination, Resistance, and Climate Dynamics in Freshwater Ecosystems

Water, Journal Year: 2024, Volume and Issue: 16(18), P. 2606 - 2606

Published: Sept. 14, 2024

The convergence of antibiotic contamination, antimicrobial resistance (AMR), and climate dynamics poses a critical environmental public health challenge. Freshwater ecosystems are increasingly threatened by the persistent presence antibiotics, which, coupled with rising global temperatures, accelerate development spread AMR. This review examines sources, pathways, mechanisms through which antibiotics enter freshwater systems how change exacerbates these processes. discusses this convergence’s ecological human impacts, highlighting implications for biodiversity health. It also explored current monitoring mitigation strategies, including advanced oxidation processes, natural-based solutions, policy interventions. Finally, identifies research gaps proposes future directions managing intertwined threats resistance, change. emphasizes need integrated, multidisciplinary approaches to protect resources in an volatile environment.

Language: Английский

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Adaptation responses of microalgal-bacterial granular sludge to sulfamethoxazole

Bioresource Technology, Journal Year: 2022, Volume and Issue: 364, P. 128090 - 128090

Published: Oct. 13, 2022

Language: Английский

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Sulfamethoxazole (SMX) Alters Immune and Apoptotic Endpoints in Developing Zebrafish (Danio rerio)

Toxics, Journal Year: 2023, Volume and Issue: 11(2), P. 178 - 178

Published: Feb. 14, 2023

Sulfamethoxazole (SMX) is a broad-range bacteriostatic antibiotic widely used in animal and fish farming also employed human medicine. These antibiotics can ultimately end up the aquatic ecosystem affect non-target organisms such as fish. To discern effect of SMX on developing zebrafish embryos larvae, we investigated broad range sub-lethal toxicity endpoints. Higher concentrations affected survivability, caused hatch delay, induced malformations including edema yolk sac, pericardial effusion, bent tail, curved spine embryos. Lower levels provoked an inflammatory response larvae at seven days post fertilization (dpf), noted by up-regulation interferon (ifn-γ) interleukin 1β (il-1β). increased expression genes related to apoptosis, BCL2-Associated Agonist Cell Death (bad) BCL2 Associated X, Apoptosis Regulator (bax) 50 µg/L decreased caspase 3 (casp3) dose-dependent manner. hyperactivity larval 500 2500 based upon light/dark preference test. Collectively, this study revealed that exposure disrupt immune system altering host defense mechanisms well transcripts apoptosis. data improve understanding chemical serves baseline for in-depth environmental risk assessment antibiotics.

Language: Английский

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Preparation of bifunctional monomer molecularly imprinted polymer filled solid-phase extraction for sensitivity improvement of quantitative analysis of sulfonamide in milk

Journal of Chromatography A, Journal Year: 2023, Volume and Issue: 1700, P. 464046 - 464046

Published: May 4, 2023

Language: Английский

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Applications of graphene-based photocatalysts for efficient functionalized degradation of some common antibiotics

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 168, P. 112941 - 112941

Published: Aug. 1, 2024

Language: Английский

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Preparation and characteristics of antibacterial PVDF ultrafiltration membrane modified with co-blending of ciprofloxacin and sulfamethoxazole

Journal of Water Process Engineering, Journal Year: 2024, Volume and Issue: 59, P. 104964 - 104964

Published: Feb. 8, 2024

Language: Английский

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