The C-8-S-isomers of ergot alkaloids — a review of biological and analytical aspects
Mycotoxin Research,
Journal Year:
2023,
Volume and Issue:
40(1), P. 1 - 17
Published: Nov. 13, 2023
Ergot
alkaloids
are
secondary
metabolites
that
produced
by
fungi
and
contaminate
cereal
crops
grasses.
The
ergot
Claviceps
purpurea
the
most
abundant
worldwide.
exist
in
two
configurations,
C-8-R-isomer
(R-epimer)
C-8-S-isomer
(S-epimer).
These
configurations
can
interconvert
to
one
another.
cause
toxic
effects
after
consumption
of
ergot-contaminated
food
feed
at
various
concentrations.
For
bioactivity
reasons,
C-8-R-isomers
have
been
studied
a
greater
extent
than
since
C-8-S-isomers
were
considered
biologically
inactive.
However,
recent
studies
suggest
contrary.
Analytical
assessment
now
includes
high
concentrations
specific
identified.
inclusion
regulatory
standards
is
reviewed.
This
review
has
identified
further
research
into
warranted.
In
addition,
recommendations
worldwide
for
should
be
implemented.
objectives
this
provide
an
overview
historic
current
assessed
C-8-S-isomers.
Specifically,
will
compare
with
emphasis
on
biological
activity
analytical
assessment.
Language: Английский
Exploring the antimitotic, thrombolytic, and cytotoxic properties of lasiosiphon glaucus or gnidia glauca (fresen.) gilg leaf alkaloid extract: insights from experimental and in silico investigations
Natural Product Research,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 5
Published: May 6, 2024
Plant
alkaloids
are
nitrogen
containing
secondary
metabolites
that
have
wide
range
of
biological
properties
including
anticancer
activity.
'Lasiosiphon
glaucus',
or
'Gnidia
glauca
(Fresen.)
Gilg,'
known
for
its
properties,
requires
exploration
to
evaluate
cytotoxic
and
effects.
The
present
study
is
aimed
L.
glaucus
leaf
alkaloid
extract
(LgLAE)
antimitotic,
thrombolytic,
properties.
LgLAE
demonstrated
comparable
antimitotic
efficacy
methotrexate
in
Allium
cepa
root
meristematic
cells.
Thrombolytic
evaluation
showed
a
maximum
observed
clot
lysis
41.39
±
0.21%
at
2
mg/100
µL.
Cytotoxicity
assay
shows
greater
inhibition
MCF-7
(144.51
μg/mL)
cancer
cell
proliferation
than
MCF-10A
cells
(409.86
μg/mL),
indicating
potential
cancer-specific
Computational
analysis
revealed
strong
binding
affinities
between
(Ergocristine,
Solasodine,
Solanocapsine,
Delphinine,
Harmidine)
relevant
receptors.
These
findings
highlight
contains
valuable
natural
compounds
with
pharmacological
effects,
particularly
it
essential
further
investigation
treatment.
Language: Английский