Association of Vitamin D with Perfluorinated Alkyl Acids in Women with and without Non-Obese Polycystic Ovary Syndrome DOI Creative Commons
Alexandra E. Butler, Thozhukat Sathyapalan, Priya Das

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1255 - 1255

Published: June 5, 2024

Background. Perfluorinated alkyl acids (PFAAs) are persistent organic pollutants affected by BMI and ethnicity, with contradictory reports of association vitamin D deficiency. Methods. Twenty-nine Caucasian women non-obese polycystic ovary syndrome (PCOS) age- BMI-matched control (n = 30) were recruited. Paired serum samples analyzed for PFAAs 13) using high-performance liquid chromatography–tandem mass spectrometry. Tandem spectrometry determined levels 25(OH)D3 the active 1,25(OH)2D3. Results. Women without PCOS did not differ in age, weight, insulin resistance, or systemic inflammation (C-reactive protein differ), but free androgen index was increased. Four detected all samples: perfluorooctane sulfonic acid (PFOS), perfluorooctanoic (PFOA), perfluorononanoic (PFNA), perfluorohexane (PFHxS). Serum PFOS higher versus controls (geometric mean [GM] 3.9 vs. 3.1 ng/mL, p < 0.05). Linear regression modeling showed that elevated PFHxS had odds a lower (OR: 2.919, 95% CI 0.82–5.75, 0.04). Vitamin between cohorts correlate any PFAAs, either alone when groups combined. When stratified into sufficiency (>20 ng/mL) deficiency (<20 ng/mL), no correlation seen. Conclusions. While analyses findings here exploratory light relatively small recruitment numbers, BMI, resistance accounted for, do appear to be related 1,25(OH)2D3 this population, nor they associated deficiency, suggesting future studies must account these factors analysis.

Language: Английский

Emerging eco-friendly technologies for remediation of Per- and poly- fluoroalkyl substances (PFAS) in Water and Wastewater: A pathway to environmental sustainability DOI
Timothy Prince Chidike Ezeorba, Emmanuel Sunday Okeke, Chidiebele Nwankwo

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 364, P. 143168 - 143168

Published: Aug. 23, 2024

Language: Английский

Citations

6
Dietary Exposure to Pesticide and Veterinary Drug Residues and Their Effects on Human Fertility and Embryo Development: A Global Overview DOI Open Access
Ambra Colopi, Eugenia Guida,

Silvia Cacciotti

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 9116 - 9116

Published: Aug. 22, 2024

Drug residues that contaminate food and water represent a serious concern for human health. The major concerns regard the possible irrational use of these contaminants, since this might increase amplitude exposure. Multiple sources contribute to overall exposure including agriculture, domestic use, personal, public veterinary healthcare, increasing origin contamination. In review, we focus on crop pesticides drug because their extensive in modern agriculture farming, which ensures production security ever-growing population around world. We discuss with respect worldwide distribution impacts, special attention harmful effects reproduction embryo development, as well link epigenetic alterations, leading intergenerational transgenerational diseases. Among most commonly implicated causing such disorders are organophosphates, glyphosate antibiotics, tetracyclines being frequently reported. This review highlights importance finding new management strategies drugs. Moreover, due still limited knowledge inter- underlie need strengthen research field, so better clarify specific each contaminant long-term impact.

Language: Английский

Citations

6
Investigating the Molecular Interactions of Two Long-Chain PFASs with Human Serum Albumin: Insights from Multispectral Analysis and Computational Methods DOI
Yao Wu, Erdeng Du, Xichen Wang

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 751, P. 151356 - 151356

Published: Feb. 1, 2025

Language: Английский

Citations

0
Number of Carbons Is a Critical Parameter for Accumulation of Per- and Polyfluoroalkyl Substances in the Human Brain DOI
Marina Suzuki, Sandra Nilsson, Claire E. Shepherd

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Per- and polyfluoroalkyl substances (PFAS), a large group of manmade chemicals, have been detected extensively in the blood people living developed countries. Although it has suggested that PFAS exposure might be associated with harmful effects on brain, few studies assessed presence brain tissues. This study aimed to evaluate concentrations broad range paired postmortem human serum samples investigate brain-to-serum concentration ratios. A partitioning experiment using PFAS-fortified animal additionally investigated differences distribution between lipid-rich water for different PFAS. Out 43 analyzed, 5 were all samples, 11 found serum, 7 samples. Two compounds observed at notably higher detection frequencies compared serum. The ratios ranged from approximately 0.04 perfluorohexanesulfonate (PFHxS) 1.3 N-methyl perfluorooctanesulfonamido acetic acid (N-MeFOSAA) clear increase total number carbons. There no two cortical regions analyzed. Results underscore necessity better understanding individual PFAS, as difference their properties can influence behavior within brain.

Language: Английский

Citations

0
Epidemiological perspectives on emerging contaminants and gout or hyperuricemia DOI Creative Commons

Weiwen Fu,

Yangyi Guang,

Zixing Zhang

et al.

Emerging contaminants, Journal Year: 2025, Volume and Issue: unknown, P. 100485 - 100485

Published: Feb. 1, 2025

Language: Английский

Citations

0
Degree of food processing and serum poly- and perfluoroalkyl substance concentrations in the US National Health and Nutrition Examination Survey, 2003–2018 DOI
Diana C. Pacyga, Jessie P. Buckley, Eurídice Martinez Steele

et al.

International Journal of Hygiene and Environmental Health, Journal Year: 2025, Volume and Issue: 266, P. 114557 - 114557

Published: March 11, 2025

Language: Английский

Citations

0
Rapid Detection of Perfluorodecanoic Acid and Perfluorooctanesulfonic Acid in Foods Using a Molecularly Imprinted Poly(o-phenylenediamine)/Modified Glassy Carbon Electrode DOI
Ting Liu, Bolu Sun,

Chun‐Yan Sang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

In the current work, a modified glassy carbon electrode (GCE) with excellent conductivity was prepared by drop-coating carboxymethyl cellulose (CMC) and multiwalled nanotubes (MWCNTs) on GCE surface. On this basis, two highly selective molecularly imprinted sensors (MIP@PFDA/modified MIP@PFOS/modified GCE) were separately obtained in situ electropolymerization of o-phenylenediamine (o-PD) perfluorodecanoic acid (PFDA) perfluorooctanesulfonic (PFOS) as templates. Under optimal conditions, sensitive quantification methods linearity ranges 0.1–1000 ng/mL 0.05–900 developed via differential pulse voltammetry using [Fe(CN)6]3–/4– redox probe. The detection limit values PFDA PFOS low 0.041 0.015 ng/mL, respectively. Both also presented great stability selectivity coexistence other interferences. Lastly, three food samples utilized to verify validity applicability recoveries 89.97%–112.27%, confirming its potential for per- polyfluoroalkyl substances (PFASs) monitoring complex matrix.

Language: Английский

Citations

0
PFAS: The Journey from Wonder Chemicals to Environmental Nightmares and the Search for Solutions DOI Creative Commons

Duwage C. Perera,

Jay N. Meegoda

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(19), P. 8611 - 8611

Published: Sept. 24, 2024

Per- and polyfluoroalkyl substances (PFAS) are diverse synthetic chemicals manufactured over seven decades. It is an aliphatic molecule with a basic hydrophobic structure of carbon fluorine linked to hydrophilic end group. Due their physicochemical properties associated the unique structure, PFAS has been used in wide variety applications including aqueous film-forming foams (AFFF), paper, carpets, non-stick cookware, etc. as they make products resistant water, heat, stains. These molecules have drawn great attention recently for properties, high stability low degradability, so-called “Forever Chemicals”. strongest carbon-fluorine bond which makes them persistent environment. Hence it contaminates natural resources endangers public health. This review discusses discovery, development, evolution from wonder chemical era nightmare era, exposure its impacts on human health environment, current remediation techniques, future trends related products. The primary objective this identify knowledge gaps contamination, methods, possible alternatives.

Language: Английский

Citations

3
Addressing emerging contaminants in agriculture affecting plant–soil interaction: a review on bio-based and nano-enhanced strategies for soil health and global food security (GFS) DOI Creative Commons
Chidiebele Nwankwo, Emmanuel Sunday Okeke,

Francis Uchenna Umeoguaju

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: April 1, 2025

Abstract The agricultural sector plays a crucial role in global food security, yet its heavy reliance on chemical inputs has led to rise emerging contaminants modern agroecosystems. This review critically examines the impacts of these soil health, plant-soil interactions, and productivity. We highlight how xenobiotic compounds from pesticides, herbicides, antibiotics, fertilizers disrupt nutrient cycling microbial communities. Key contaminant classes, including pharmaceuticals, industrial pollutants, were discussed alongside their specific effects ecosystems. Additionally, this also explores innovative bio-based nano-enhanced remediation strategies, such as rhizosphere microbiome management nano-biofertilizers, which show promise mitigating impacts. Despite advancements, challenges persist regulatory frameworks, technology adoption, education. To address theses issues, we propose holistic approach integrating research, policy, stakeholder engagement. Our findings urgent need for sustainable practices that prioritize health ecosystem integrity ensure long-term security. Graphical

Language: Английский

Citations

0
Current research development on food contaminants, future risks, regulatory regime and detection technologies: A systematic literature review DOI Creative Commons
Keru Duan,

Guoqing Pang,

Yanqing Duan

et al.

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 381, P. 125246 - 125246

Published: April 9, 2025

Food contaminants pose serious threats to public health, with profound negative impacts on the economy, society, and environment. However, there is a lack of timely comprehensive reviews latest developments in food effective measures prevent contamination, particularly through novel intelligent detection technologies regulatory regimes. This study addresses this knowledge gap by presenting review literature, focusing current types contaminants, advances technologies, emerging risks, frameworks. The reviewed 116 relevant articles published between 2019 2024 conducted thematic analysis. were classified into three categories: biological, chemical, physical. identified six key drivers future safety risks: demographic change, economic factors, environmental conditions, geopolitical shifts, consumer priorities, technological advancements. Findings reveal uneven understanding concern, their impact system, environment, human health. These findings highlight need for research systematically identifying validating regional differences contamination prevention assessing extent which these effectiveness prevention, mitigation, control efforts. also call more international cooperation active involvement technology partners facilitate application cutting-edge control.

Language: Английский

Citations

0