Structure Characterization and Treatment Effect of Zingiber officinale Polysaccharide on Dextran Sulfate Sodium-Induced Ulcerative Colitis

Foods, Journal Year: 2025, Volume and Issue: 14(5), P. 753 - 753

Published: Feb. 23, 2025

Ulcerative colitis (UC) is on the rise all over world. Zingiber officinale polysaccharide (ZOP-1) has good anti-inflammatory and antioxidant effects, but therapeutic effect mechanism of ZOP-1 UC are still unclear. obtained by water extraction alcohol precipitation was analyzed methylation NMR. At same time, in treatment clarified hematoxylin-eosin (HE) staining, metagenomics, immunohistochemistry, protein blot (Wb). structure →4,6)-β-Glcp-1→ →3,6)-α-Galp-(1→ constitute main chain, there were two branched chain →4)-β-Glcp(1→, α-Araf(1→ as end group. significantly improved shortening thickening colon, changed index immune organs, inhibited production inflammatory factors mice with ulcerative colitis, intestinal flora mice, increased content short-chain fatty acids (SCFAs) intestine, controlled TLR4/NF-κB/MAPK signaling pathway, thus preventing treating DSS-induced mice. alleviated controlling expression cytokines, thereby reducing inflammation oxidative stress, enhancing integrity, modulating flora, regulating levels SCFAs.

Language: Английский

The structural characteristics, beneficial effects and biological mechanisms of food and medicinal plant polysaccharides on exercise-induced fatigue: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144046 - 144046

Published: May 1, 2025

Language: Английский