Exposure to microplastics during pregnancy and fetal liver function DOI Creative Commons
Chia‐Chun Wang, Hua Chang, Huan Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 294, P. 118099 - 118099

Published: April 1, 2025

Emerging evidence suggests that in-utero exposure to microplastics (MPs) may have physiological consequences for fetal development, yet human data remain limited. This study investigates the association between placental microplastic and umbilical liver enzyme levels as markers of hepatic function. A prospective cohort was conducted in Shenyang, China, including 1057 pregnant women. Placental quantification performed using LD-IR chemical imaging, targeting polyvinyl chloride (PVC), polypropylene (PP), polybutylene succinate (PBS). Umbilical cord blood collected at delivery, alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate (AST), gamma-glutamyl transferase (GGT) were analyzed biochemical assays. Associations assessed via multivariable regression models adjusting maternal socioeconomic confounders. Mixture effects examined Bayesian Kernel Machine Regression (BKMR) quantile g-computation (g-comp). detected most samples (PVC: 88.4 %, PP: 88.8 PBS: 89.1 %), with a median total MPs 12 particles per 10 g tissue (IQR: 8). Higher PVC significantly associated increased ALP (β = 28.07, 95 % CI: 6.65-49.49, p 0.01). PP correlated positively ALT 0.63, 0.01-1.25, 0.05) AST 3.42, 0.87-5.96, Both burden exhibited strong associations GGT elevation (p < analysis revealed significant overall on 30.04, 11.15-48.92, 0.01), 7.30, 4.33-10.27, 22.98, 7.49-38.46, showing suggestive positive trend. Our findings provide novel MP is altered levels, particularly ALP, AST, GGT, indicating potential impacts These results underscore need further investigation into underlying mechanisms long-term health implications prenatal exposure.

Language: Английский

Exposure to microplastics during pregnancy and fetal liver function DOI Creative Commons
Chia‐Chun Wang, Hua Chang, Huan Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 294, P. 118099 - 118099

Published: April 1, 2025

Emerging evidence suggests that in-utero exposure to microplastics (MPs) may have physiological consequences for fetal development, yet human data remain limited. This study investigates the association between placental microplastic and umbilical liver enzyme levels as markers of hepatic function. A prospective cohort was conducted in Shenyang, China, including 1057 pregnant women. Placental quantification performed using LD-IR chemical imaging, targeting polyvinyl chloride (PVC), polypropylene (PP), polybutylene succinate (PBS). Umbilical cord blood collected at delivery, alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate (AST), gamma-glutamyl transferase (GGT) were analyzed biochemical assays. Associations assessed via multivariable regression models adjusting maternal socioeconomic confounders. Mixture effects examined Bayesian Kernel Machine Regression (BKMR) quantile g-computation (g-comp). detected most samples (PVC: 88.4 %, PP: 88.8 PBS: 89.1 %), with a median total MPs 12 particles per 10 g tissue (IQR: 8). Higher PVC significantly associated increased ALP (β = 28.07, 95 % CI: 6.65-49.49, p 0.01). PP correlated positively ALT 0.63, 0.01-1.25, 0.05) AST 3.42, 0.87-5.96, Both burden exhibited strong associations GGT elevation (p < analysis revealed significant overall on 30.04, 11.15-48.92, 0.01), 7.30, 4.33-10.27, 22.98, 7.49-38.46, showing suggestive positive trend. Our findings provide novel MP is altered levels, particularly ALP, AST, GGT, indicating potential impacts These results underscore need further investigation into underlying mechanisms long-term health implications prenatal exposure.

Language: Английский

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