Tebuconazole-based fungicide impairs embryonic development of the South African Clawed Frog Xenopus laevis DOI Creative Commons

Vanessa Ihle,

Hannah Flach,

Florian Kaminski

et al.

Environmental Toxicology and Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 104708 - 104708

Published: April 1, 2025

Tebuconazole (TBZ) is a broad-spectrum fungicide that disrupts fungal cell membrane. Due to its extensive application in agriculture, TBZ frequently detected aquatic ecosystems, posing potential risks amphibians. However, the effects of TBZ-based formulations on amphibian development remain poorly understood. The present study investigates Tebucur embryogenesis South African clawed frog. Two-cell stage embryos were exposed varying concentrations (0.01-100mg a.i./L) static non-renewal bioassay. exposure time varied between four and 14 days, depending desired developmental analysis method. resulted mortality with LC50-value 8.0mg a.i./L at days. As well, various morphological abnormalities during neural cardiac emerged. Additionally, reduction overall mobility was observed. This underlines need for strict regulation use TBZ-formulations.

Language: Английский

Tebuconazole-based fungicide impairs embryonic development of the South African Clawed Frog Xenopus laevis DOI Creative Commons

Vanessa Ihle,

Hannah Flach,

Florian Kaminski

et al.

Environmental Toxicology and Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 104708 - 104708

Published: April 1, 2025

Tebuconazole (TBZ) is a broad-spectrum fungicide that disrupts fungal cell membrane. Due to its extensive application in agriculture, TBZ frequently detected aquatic ecosystems, posing potential risks amphibians. However, the effects of TBZ-based formulations on amphibian development remain poorly understood. The present study investigates Tebucur embryogenesis South African clawed frog. Two-cell stage embryos were exposed varying concentrations (0.01-100mg a.i./L) static non-renewal bioassay. exposure time varied between four and 14 days, depending desired developmental analysis method. resulted mortality with LC50-value 8.0mg a.i./L at days. As well, various morphological abnormalities during neural cardiac emerged. Additionally, reduction overall mobility was observed. This underlines need for strict regulation use TBZ-formulations.

Language: Английский

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