The
capacity
to
produce
complicated
structures
with
high
precision
has
made
it
possible
make
personalized
implants
that
fit
the
individual
anatomy
of
patient,
improving
outcomes
and
lowering
risks.
For
drug
testing
screening,
3D-printed
tissue
models
have
been
employed,
current
research
is
looking
into
how
fabricate
intricate
microstructures
delivery
systems.
This
chapter
explores
3D
printing
potential
transform
healthcare
by
making
create
patient-specific
as
well
useful
tissues
organs
for
transplantation.
It
important
consider
aspects
like
biocompatibility,
printability,
mechanical
qualities,
degradability,
cost
when
choosing
bioinks
biomaterials.
In
vitro
crucial
determine
these
materials'
effectiveness,
used
in
morphological,
rheological,
chemical,
characterization
materials.
Finally,
recent
studies
on
biomaterials
using
various
techniques
are
reviewed,
including
their
limitations
implications
future
research.
Advanced Materials Technologies,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 11, 2024
Abstract
Organ‐on‐chip
(OoC)
systems
are
microfluidic
in
vitro
platforms
constructed
to
expand
the
current
understanding
of
organ‐level
physiology
and
response.
This
technology
holds
significant
potential
transform
drug
discovery,
precision
medicine,
disease
modeling
while
reducing
animal
model
use.
Recent
developments
OoC
have
shown
great
promise,
demonstrated
using
relatively
simple
designs.
Currently,
consensus
OoC‐related
literature
is
that
future
lies
development
robust
offer
higher
throughput,
improved
customization,
levels
integration
sensing
actuation
modalities.
The
implementation
silicon
micro‐nanofabrication
technologies
can
foster
such
a
transition,
but
application
field
remains
limited.
In
this
review,
an
overview
provided
been
or
be
applied
realization
compact
systems,
with
focus
on
integrated
Emerging
highlighted
for
heterogeneous
silicon‐based
polymer‐based
components
multimodal
platforms.
Finally,
most
promising
avenues
outlined
within
framework
biomedical
research
personalized
medicine.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 12, 2023
Abstract
For
studying
stem
cell-derived
islet
organoids
(SC-islets)
in
an
organ-on-chip
platform,
we
have
developed
a
reversed
phase
liquid
chromatography
tandem
mass
spectrometry
(RPLC-MS/MS)
method
allowing
for
simultaneous
determination
of
insulin,
somatostatin-14,
and
glucagon,
with
improved
matrix
robustness
compared
to
earlier
methodology.
Combining
phenyl/hexyl-C18
separations
using
2.1
mm
inner
diameter
LC
columns
triple
quadrupole
spectrometry,
identification
quantification
were
secured
negligible
variance
retention
time
quantifier/qualifier
ratios,
levels
carry-over
(<
2%),
sufficient
precision
(±
10%
RSD)
accuracy
15%
relative
error)
without
use
internal
standard.
The
here
RPLC-MS/MS
showed
that
the
SC-islets
insulin
response
dependent
on
glucose
concentration,
produce
release
somatostatin-14
glucagon.
these
peptide
hormones
was
compatible
unfiltered
off-line
sample
collection
from
cultivated
pump-less,
recirculating
(rOoC)
platform.
background
secretion
not
significantly
different
rOoC
device
standard
cell
culture
well-plate.
Taken
together,
is
well
suited
multi-hormone
measurements
International Journal of Community Medicine and Public Health,
Journal Year:
2023,
Volume and Issue:
11(1), P. 526 - 532
Published: Dec. 27, 2023
Innovations
in
laboratory
medicine
face
additional
challenges
due
to
the
unmet
need
for
extremely
precise
methods
of
disease
diagnosis.
Developments
mass
spectrometry-based
biomarker
identification
are
constantly
expanding
field
clinical
More
vitro
diagnostics
anticipated
move
from
bench
bedside
shortly,
although
several
currently
incorporated
into
standard
procedures.
The
molecular
detection
by
spectrometry
technique
is
very
effective
diagnosis
and
therapeutic
monitoring
because
its
high
sensitivity,
specificity,
short
turnaround
time.
Mass
a
potent
analytical
instrument
that
may
be
used
analyse
variety
materials
matrices;
use
applications
rising.
For
prognostics
diagnostic
purposes,
imaging
has
been
widely
utilized
distinguish
between
healthy
diseased
tissues.
Modern
single-cell
studies
will
benefit
cutting-edge
applications,
which
offer
comprehensive
cellular
biochemical
data
mechanistic
comprehension
and,
eventually,
development
interventions.
Within
medicine,
application
crucial,
especially
terms
drug
monitoring.
This
review
on
future
prospects
promises
an
insightful
exploration
evolving
landscape
settings,
delving
current
shedding
light
potential
advancements,
search
PubMed,
ScienceDirect,
Web
Science
databases
was
conducted.
The
capacity
to
produce
complicated
structures
with
high
precision
has
made
it
possible
make
personalized
implants
that
fit
the
individual
anatomy
of
patient,
improving
outcomes
and
lowering
risks.
For
drug
testing
screening,
3D-printed
tissue
models
have
been
employed,
current
research
is
looking
into
how
fabricate
intricate
microstructures
delivery
systems.
This
chapter
explores
3D
printing
potential
transform
healthcare
by
making
create
patient-specific
as
well
useful
tissues
organs
for
transplantation.
It
important
consider
aspects
like
biocompatibility,
printability,
mechanical
qualities,
degradability,
cost
when
choosing
bioinks
biomaterials.
In
vitro
crucial
determine
these
materials'
effectiveness,
used
in
morphological,
rheological,
chemical,
characterization
materials.
Finally,
recent
studies
on
biomaterials
using
various
techniques
are
reviewed,
including
their
limitations
implications
future
research.
