Analytical Letters,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 16
Published: Dec. 31, 2024
For
the
first
time,
an
adenine-modified
pencil
graphite
electrode
(AD/PGE)
was
used
to
determine
dopamine
in
synthetic
urine
samples.
The
electrochemical
properties
of
sensor
were
analyzed
using
cyclic
voltammetry
(CV),
impedance
spectroscopy
(EIS),
and
linear
sweep
(LSV)
aqueous
solutions.
Phosphate
buffer
solution
(PBS)
at
different
pH
levels
served
as
supporting
electrolyte.
modified
characterized
with
CV,
EIS,
scanning
electron
microscopy
(SEM).
Optimal
square
wave
(SWV)
parameters
set
for
detection.
calibration
curve
(10
0.1
µM)
showed
a
correlation
coefficient
0.9962.
detection
limit
32.4
nM.
Sensors and Actuators B Chemical,
Journal Year:
2024,
Volume and Issue:
404, P. 135282 - 135282
Published: Jan. 5, 2024
Interleukin-6
(IL-6)
is
an
important
cytokine
involved
in
immune
responses
and
maintaining
body
homeostasis.
Elevated
IL-6
levels,
exceeding
~40
pg/mL
bodily
fluids,
are
associated
with
inflammation
diseases
such
as
COVID-19,
cardiovascular
disorders,
Alzheimer's,
necessitating
real-time
health
monitoring
for
personalized
healthcare.
In
this
study,
we
developed
a
highly
sensitive
selective
sensing
platform
by
depositing
poly(o-phenylenediamine)
(P(o-PD))-based
molecularly
imprinted
polymer
(MIP)
onto
oxygen-functionalized
screen-printed
carbon
electrode
gold
nanoparticles,
3-aminopropyltriethoxysilane
(APTES),
glutaraldehyde
(GA).
While
APTES
enhanced
the
peak
current
due
to
redox
probe
adsorption,
GA
reduced
it
non-conductive
aldehyde
groups.
This
functionalized
surface
improved
hydrophilicity
presence
of
amino
carbonyl
We
identified
that
120-minute
NaCl
treatment
effectively
removed
templates,
ensuring
successful
embedding
P(o-PD)
matrix.
calculated
imprinting
factor
11.2,
indicating
effective
specific
binding
sites
within
MIP,
resulting
robust
response
IL-6.
After
optimizing
MIP
deposition
through
five
cycles,
detected
concentrations
ranging
from
2
400
pg/mL,
sensitivity
3.48
μA/log(pg/mL)
limit
detection
1.74
pg/mL.
When
tested
real
human
serum,
sensor
encountered
challenges
matrix
adsorbing
other
active
molecules.
Despite
challenge,
our
demonstrates
high
selectivity
long-term
stability
detection.
These
qualities
position
well-suited
point-of-care
diagnostics,
emphasizing
its
potential
reliable
tool
real-world
applications.
Chemosensors,
Journal Year:
2025,
Volume and Issue:
13(1), P. 7 - 7
Published: Jan. 3, 2025
In
this
work,
the
influence
of
surface
functionalization
due
to
synthesis
conditions
graphene
oxide
quantum
dots
GOQDs
was
evaluated
for
dopamine
(DA)
detection.
were
synthesized
using
HNO3
(6
M
or
8
M)
through
a
liquid-phase
oxidation
method.
The
characterization
(HRTEM,
FTIR,
Raman,
and
XRD)
evaluation
by
amperometry
(AMP)
differential
pulse
voltammetry
(DPV)
showed
that
GOQDs-8
with
higher
oxygen
content
more
sensitive
selective
in
DA
detection
than
GOQDs-6.
synergistic
effects
electrostatic
attraction
from
glassy
carbon
electrode
negatively
charged
surface,
inner-sphere
mechanism,
edge
effect
lower
particle
size
resulted
amplified
electrochemical
signal
achieving
at
nanomolar
level
AMP
DPV.
When
AMP,
GCE/GOQDs-8
sensitivity
0.0422
μA
μM–1,
limit
(LOD)
17.6
nM,
linear
range
0.1
100
μM,
minimal
interference
uric
acid,
levodopa,
acetaminophen.
contrast,
DPV,
exhibited
0.0616
LOD
506
0.1–30
μM
remarkable
selectivity
all
interferent
species.
assay
GOQDs-8/GCE
sensor
normal
human
serum
proved
be
feasible
practical
determination
DA.
recovery
obtained
94.1
112.8%
relative
standard
deviation
(RSD),
n
=
3
less
3.62%.
oxygen-rich
material
promising
performance
can
further
improved
additional
nanocarbon
conducting
polymers
supports.
ChemNanoMat,
Journal Year:
2024,
Volume and Issue:
10(6)
Published: April 16, 2024
Abstract
Functionalized
multi‐walled
carbon
nanotubes
(MWCNTs)
have
enticed
remarkable
attention
in
the
field
of
electrochemical
sensing
applications.
Dopamine
(DA)
is
a
monoamine
neurotransmitter
released
brain
acting
as
chemical
messenger
that
communicates
messages
between
nerve
cells
and
rest
body.
Therefore,
there
significant
technological
urge
for
development
sensors
DA
body
fluids.
In
this
context,
nitrogen‐functionalized
MWCNTs
(TM‐CNT600)
were
fabricated
by
thermal
annealing
carboxylic
acid
functionalized
with
thiourea
at
600
°C
under
N
2
atmosphere.
The
XPS
spectrum
reveals
presence
nitrogen‐containing
functionalities
as‐prepared
TM‐CNT600.
FTIR
results
show
−OH,
C−N
C−S
functional
groups.
further
corroborates
quantifies
predominant
groups
material.
material
was
investigated
potential
sensor
detection
dopamine
(DA).
case
TM‐CNT600/GCE,
linear
relationship
concentration
observed
range
10.7–24.2
μM
limit
(LOD)
1.42
using
sweep
voltammetry
(LSV).
These
highlight
TM‐CNT600
modified
GCE
an
efficient
