Microchimica Acta, Journal Year: 2024, Volume and Issue: 191(12)
Published: Nov. 28, 2024
Language: Английский
Microchimica Acta, Journal Year: 2024, Volume and Issue: 191(12)
Published: Nov. 28, 2024
Language: Английский
Food Chemistry, Journal Year: 2025, Volume and Issue: 474, P. 143193 - 143193
Published: Feb. 3, 2025
Language: Английский
Citations
2Chemosensors, Journal Year: 2025, Volume and Issue: 13(1), P. 26 - 26
Published: Jan. 20, 2025
Cardiac troponin I (cTnI) is a crucial biomarker for the early detection of acute myocardial infarction (AMI), playing significant role in cardiac health assessment. Molecularly imprinted polymers (MIPs) are valued their stability, ease fabrication, reusability, and selectivity. However, using analyte as template can be costly, especially if expensive. In such cases, dummy (DT) with similar chemico-physical properties useful. This study aimed to design DT-MIP cTnI cytochrome c (Cyt c) template, combining computational experimental approaches. Molecular docking identified binding sites on Cyt poly(o-phenylenediamine) (5PoPD) pentamers. Interactions energies were examined all-atom molecular dynamics (MDs) simulations structural interaction fingerprint (SIFt) calculations. A DT-MIP-modified electrode was prepared by electropolymerizing o-PD presence template. Electrochemical techniques monitored electropolymerization, removal, target analyte. The results showed that DT-MIPs exhibited high affinity cTnI, consistent observed MD simulations. satisfactory correlation between validated our model-based approach rational molecularly polymers.
Language: Английский
Citations
1Separation and Purification Technology, Journal Year: 2024, Volume and Issue: 353, P. 128548 - 128548
Published: June 25, 2024
Language: Английский
Citations
6Molecules, Journal Year: 2024, Volume and Issue: 29(18), P. 4472 - 4472
Published: Sept. 20, 2024
Despite advancements in the sensitivity and performance of analytical instruments, sample preparation remains a bottleneck process. Currently, solid-phase extraction is more widely used than traditional organic solvent due to its ease use lower requirements. Moreover, various microextraction techniques such as micro extraction, dispersive microextraction, stir bar sorptive liquid-phase magnetic bead have been developed minimize size, reduce usage, enable automation. Among these, in-tube (IT-SPME) using capillaries devices has gained attention an advanced “green technique” that combines miniaturization, on-line automation, reduced consumption. Capillary tubes IT-SPME are categorized into configurations: inner-wall-coated, particle-packed, fiber-packed, rod monolith, operating either draw/eject system or flow-through system. Additionally, developments novel adsorbents monoliths, ionic liquids, restricted-access materials, molecularly imprinted polymers (MIPs), graphene, carbon nanotubes, inorganic nanoparticles, organometallic frameworks improved efficiency selectivity. MIPs, particular, stable, custom-made with molecular recognition capabilities formed during synthesis, making them exceptional “smart adsorbents” for selective preparation. The MIP fabrication process involves three main stages: pre-arrangement capability, polymerization, template removal. After forming template-monomer complex, polymerization creates polymer network where molecules anchored, final step removing produce cavities complementary molecules. This review first paper focus on MIP-based IT-SPME, which integrates selectivity MIPs efficient summarizes recent applications.
Language: Английский
Citations
5Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 112361 - 112361
Published: Dec. 1, 2024
Language: Английский
Citations
5Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: 1349, P. 343799 - 343799
Published: Feb. 21, 2025
Language: Английский
Citations
0Separation and Purification Technology, Journal Year: 2025, Volume and Issue: unknown, P. 132375 - 132375
Published: March 1, 2025
Language: Английский
Citations
0iScience, Journal Year: 2025, Volume and Issue: 28(4), P. 112186 - 112186
Published: March 10, 2025
Molecular imprinting has become an effective technology in the realm of diagnosing diseases, providing unparalleled specificity and sensitivity. This method is a promising trend current medical research. review examines utilization molecularly imprinted polymers (MIPs) theranostic that integrates diagnostic functionalities for personalized medicine. The present work briefly discusses fundamental concepts molecular how it evolved into versatile platform. Subsequently, MIPs advancement biosensors focused, specifically emphasizing their contribution to detection diagnosis diseases. therapeutic potential MIPs, focusing on targeted drug delivery controlled release systems integration platforms explored through case studies, showcasing technology's ability simultaneously diagnose treat Finally, we address challenges facing discuss future perspectives, this revolutionize next generation.
Language: Английский
Citations
0Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: 1352, P. 343941 - 343941
Published: March 14, 2025
Language: Английский
Citations
0Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113376 - 113376
Published: March 1, 2025
Language: Английский
Citations
0