High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(29), P. 12784 - 12822

Published: July 10, 2024

In the modern "omics" era, measurement of human exposome is a critical missing link between genetic drivers and disease outcomes. High-resolution mass spectrometry (HRMS), routinely used in proteomics metabolomics, has emerged as leading technology to broadly profile chemical exposure agents related biomolecules for accurate measurement, high sensitivity, rapid data acquisition, increased resolution space. Non-targeted approaches are increasingly accessible, supporting shift from conventional hypothesis-driven, quantitation-centric targeted analyses toward data-driven, hypothesis-generating exposome-wide profiling. However, HRMS-based exposomics encounters unique challenges. New analytical computational infrastructures needed expand analysis coverage through streamlined, scalable, harmonized workflows pipelines that permit longitudinal tracking, retrospective validation, multi-omics integration meaningful health-oriented inferences. this article, we survey literature on state-of-the-art technologies, review current informatic pipelines, provide an up-to-date reference exposomic chemists, toxicologists, epidemiologists, care providers, stakeholders health sciences medicine. We propose efforts benchmark fit-for-purpose platforms expanding space, including gas/liquid chromatography-HRMS (GC-HRMS LC-HRMS), discuss opportunities, challenges, strategies advance burgeoning field exposome.

Language: Английский

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Liquid and gas-chromatography-mass spectrometry methods for exposome analysis

Journal of Chromatography A, Journal Year: 2025, Volume and Issue: unknown, P. 465728 - 465728

Published: Jan. 1, 2025

Language: Английский

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Precise characterization of the presence and fate of plastic oligomers in water

Nature Water, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

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Fate and transformation of psychotropic drugs in urban wastewater systems and receiving rivers via the integration of targeted and suspect screening analysis

Water Research, Journal Year: 2025, Volume and Issue: 276, P. 123292 - 123292

Published: Feb. 13, 2025

Language: Английский

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Quantitative comparison of bile acid glucuronides sub-metabolome between intrahepatic cholestasis and healthy pregnant women

Analytical and Bioanalytical Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: July 11, 2024

Language: Английский

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