Elevated Mammalian Cell Cytotoxicity of Chlorinated Drinking Waters in the Presence of CuO

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

It has been demonstrated previously that cupric oxide (CuO) can enhance the formation of one- to two-carbon-atom disinfection byproducts (DBPs) during water chlorination. Effects CuO on Chinese hamster ovary cell cytotoxicity chlorinated and underlying mechanisms were investigated in this study. Results showed 0.1 g L–1 elevated waters by 20% 120% at initial bromide concentrations 15 415 μg L–1, respectively. Increasing dose increased induced both known unknown DBP fractions, a more pronounced elevation was observed for former one. Unknown fractions accounting >70% characterized Fourier transform ion cyclotron resonance mass spectrometry. The presence decreased average molecular weight (416.4 vs 412.3 Da) assigned ∼2350 formulas after chlorination but number bromine-containing (165 328). contribution bromine addition/substitution pathways alteration identified almost doubled absence CuO. preferential brominated DBPs ascribed higher rate constant CuO–HOBr than CuO–HOCl complex lower adsorption energies based density functional theory calculations. This work provides insights into DBP-associated its mitigation strategies copper-containing distribution systems.

Language: Английский

Urban stormwater cytotoxicity: Influence of land use, toxicity mechanism and implication for reuse safety

Process Safety and Environmental Protection, Journal Year: 2025, Volume and Issue: unknown, P. 107120 - 107120

Published: April 1, 2025

Language: Английский