Challenges and Current Trends in Preventing Antimicrobial Resistance in EU Water Law Context DOI Creative Commons
Justyna Rogowska, Grażyna Gałęzowska, Agnieszka Zimmermann

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 14(1), P. 18 - 18

Published: Dec. 31, 2024

The increasing consumption of pharmaceuticals, including antibiotics, and their improper disposal have resulted in both pharmaceuticals metabolites being released into the environment, where they pose a risk to ecosystems human health. One most serious threats public health associated with presence antibiotics environment is antimicrobial resistance (AMR). In order combat AMR, legal aspect water protection becomes critical area action. This article analyzes current challenges legislative developments European Union (EU) aimed at mitigating pharmaceutical contamination aquatic environments, particularly regard AMR. It traces evolution EU policies from initial surface groundwater directives recent updates Water Framework Directive, Groundwater Directive Environmental Quality Standards focusing on integration contaminants regulatory framework. addition, these changes include update Watch List system for monitoring emerging contaminants, adoption effects-based methods (EBMs) assessment status streamlining process respond more quickly environment. EU’s strategic approach emphasized as key framework harmonizing environmental standards addressing problem AMR through sustainable practices. study advocates proactive, integrated policy that aligns actions scientific advancements protect ecosystem integrity.

Language: Английский

Capturing temporal variation in aquatic ecotoxicological risks: Chemical- versus effect-based assessment DOI Creative Commons
Harry Boonstra, Milo L. de Baat,

F. van der Meer

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 967, P. 178797 - 178797

Published: Feb. 12, 2025

The integration of effect-based and chemical profiling has been advocated to assess the potential ecotoxicological risks posed by mixtures present in aquatic ecosystems. However, concentrations contaminants surface waters can vary greatly over time space, making it challenging ensure risk assessment. Although first results are promising, not yet proven that these combined approaches also capable capturing temporal variation risks. study aimed test this combining passive time-integrative sampling with chemical-analytical techniques agricultural waterways. Silicone rubber sheets polar organic integrative samplers (POCIS) were deployed four water bodies consecutive six-week periods. Passive sampler extracts analysed using a battery 22 vitro vivo bioassays tandem extensive target analysis 225 compounds. induced fluctuating bioassay responses for all locations during periods, highlighting presence spatial toxic pressure. A range compounds, primarily fungicides herbicides, detected periods at variable concentrations, persistent but pressure regions. toxicity observed could solely be attributed chemicals 6 % cases those explaining only 1-16.9 effects, indicating predominantly caused undetected chemicals. Risk assessments based on revealed frequent exceedances trigger values It is concluded better capture variations than traditional analyses, advanced needed explain bioanalytical response profiles.

Language: Английский

Citations

1
Sample Preparation Approaches for Determination of Quinolones in Aqueous Matrixes: Systematic Review DOI Creative Commons
Tainara Aparecida Nunes Ribeiro,

Daiane Dulcileia Moraes de Paula,

Marcella Matos Cordeiro Borges

et al.

ACS Measurement Science Au, Journal Year: 2024, Volume and Issue: 5(1), P. 19 - 30

Published: Nov. 14, 2024

Quinolones and fluoroquinolones are among the most used antibiotics worldwide. Antibiotic resistance genes can be acquired by human pathogens from ambient microorganisms, which lead to a treatment failure for bacterial infections. Furthermore, determining levels of quinolones in aqueous matrixes is crucial safeguarding both health environment. Using sample preparation techniques essential since these compounds commonly present at trace levels. Therefore, we aimed investigate main analytical methods determination samples based on systematic literature review. We only considered studies that presented more robust allowed accurate precise measurement quinolones/fluoroquinolones matrixes. In total, 18 articles met inclusion criteria were our analysis. A total 21 quinolone antibacterial agents investigated water 13 countries, showing potential risk around world. Ciprofloxacin (72.2%), enrofloxacin (61.1%), norfloxacin (50%), marbofloxacin, levofloxacin (33.3%) frequently evaluated compounds. High-Performance Liquid Chromatography stands out as predominant instrumental technique separation identification Additionally, selected this review, 44% employed liquid-liquid extraction its miniaturized versions, while 56% opted solid-phase variations. Finally, it important note final method efficiency relies entire process, selecting with appropriate detection limits, going through preparation, achieving good recovery adjustments parameters archive

Language: Английский

Citations

0
Integrating Green and White Analytical Principles for Endocrine Disruptor Analysis in Aqueous Matrices: From Routine Methods to Emerging Technologies DOI Creative Commons
Michelle Klein,

Martin D. Klassen,

Torsten Schmidt

et al.

Green Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 100186 - 100186

Published: Dec. 1, 2024

Language: Английский

Citations

0
Challenges and Current Trends in Preventing Antimicrobial Resistance in EU Water Law Context DOI Creative Commons
Justyna Rogowska, Grażyna Gałęzowska, Agnieszka Zimmermann

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 14(1), P. 18 - 18

Published: Dec. 31, 2024

The increasing consumption of pharmaceuticals, including antibiotics, and their improper disposal have resulted in both pharmaceuticals metabolites being released into the environment, where they pose a risk to ecosystems human health. One most serious threats public health associated with presence antibiotics environment is antimicrobial resistance (AMR). In order combat AMR, legal aspect water protection becomes critical area action. This article analyzes current challenges legislative developments European Union (EU) aimed at mitigating pharmaceutical contamination aquatic environments, particularly regard AMR. It traces evolution EU policies from initial surface groundwater directives recent updates Water Framework Directive, Groundwater Directive Environmental Quality Standards focusing on integration contaminants regulatory framework. addition, these changes include update Watch List system for monitoring emerging contaminants, adoption effects-based methods (EBMs) assessment status streamlining process respond more quickly environment. EU’s strategic approach emphasized as key framework harmonizing environmental standards addressing problem AMR through sustainable practices. study advocates proactive, integrated policy that aligns actions scientific advancements protect ecosystem integrity.

Language: Английский

Citations

0