Drug resistance mechanisms and treatment strategies mediated by Ubiquitin-Specific Proteases (USPs) in cancers: new directions and therapeutic options

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 3, 2024

Abstract Drug resistance represents a significant obstacle in cancer treatment, underscoring the need for discovery of novel therapeutic targets. Ubiquitin-specific proteases (USPs), subclass deubiquitinating enzymes, play pivotal role protein deubiquitination. As scientific research advances, USPs have been recognized as key regulators drug across spectrum treatment modalities, including chemotherapy, targeted therapy, immunotherapy, and radiotherapy. This comprehensive review examines complex relationship between mechanisms, focusing on specific strategies highlighting influence DNA damage repair, apoptosis, characteristics stem cells, immune evasion, other crucial biological functions. Additionally, highlights potential clinical significance USP inhibitors means to counter treatment. By inhibiting particular USP, cells can become more susceptible variety anti-cancer drugs. The integration with current therapies offers promising strategy circumvent resistance. Therefore, this emphasizes importance viable targets insight into fruitful directions future development. Targeting presents an effective method combat various types, leading enhanced better patient outcomes.

Language: Английский

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Assessment of Anticancer Properties of Thai Plants

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 122 - 164

Published: March 11, 2024

Cancer, a critical health concern, necessitates safer, more effective treatments. This chapter explores the anticancer potential of traditional Thai plants, which, despite being underresearched, show significant promise. It focuses on bioactive compounds and their efficacy against various cancer types. The categorizes these plants based active components reviews both laboratory animal studies to understand underlying mechanisms involved in inhibiting cell growth, inducing death, preventing tumor blood vessel formation. Clinical trials supporting findings are also highlighted. Given improve or innovate treatments, present encouraging prospects. However, further research is essential confirm safety approaches. These suggest that could lead development innovative drugs, signaling advancements therapy.

Language: Английский

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O-carboxymethyl chitosan-grafted-cholesterol succinic acid monoester nanomicelles improve oral absorption of cannabidiol: Preparation, intestinal absorption in vitro, and pharmacokinetics in vivo

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106763 - 106763

Published: Feb. 1, 2025

Language: Английский

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Picropodophyllin, an IGF‑1 receptor inhibitor, enhances oxaliplatin efficacy in chemoresistant colorectal cancer HCT116 cells by reducing metastatic potential

Oncology Letters, Journal Year: 2025, Volume and Issue: 29(5), P. 1 - 12

Published: March 6, 2025

The insulin‑like growth factor receptor (IGF‑1R) axis drives cellular growth, survival and chemoresistance in colorectal cancer (CRC) by promoting proliferative signaling, anti‑apoptotic effects epithelial‑mesenchymal transition (EMT). Targeting the IGF‑1R pathway is therefore a promising strategy, not only for overcoming drug resistance, but also reducing migration metastatic behavior related to EMT. present study aimed evaluate potential of picropodophyllin (PPP), selective inhibitor, enhance oxaliplatin (OX) HCT116 OX‑resistant HCT116‑R cells. Cell viability was evaluated using resazurin‑based assay following 48‑h combination treatment with OX at its IC₅₀ concentrations (HCT116 cells, 53 µM 324 µM) PPP (1 µM). Migration assessed wound healing assays, images captured analyzed 0 48 h. Additionally, immunofluorescence staining performed assess E‑cadherin vimentin expression, evaluating epithelial mesenchymal characteristics. In (53 significantly reduced cell 0.65‑fold compared alone (P=0.0286). Wound assays demonstrated that combining decreased migration, 0.34‑fold 0.22‑fold reductions, respectively (P<0.05). Immunofluorescence revealed this increased 1.37‑ 1.63‑fold, (P<0.05), indicating role enhancing characteristics EMT‑related resistance. These findings highlight cytotoxic anti‑metastatic chemo‑resistant CRC thus offering strategy resistance improving patient outcomes treatment.

Language: Английский

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Plant Terpenoids in Combination with Conventional Therapeutics in Colorectal Cancer: A Promising Option

Current Oncology Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Language: Английский

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Epigallocatechin gallate with nobiletin as a novel combination therapy to induce autophagy and apoptosis in oral cancer

Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: 500, P. 117380 - 117380

Published: May 9, 2025

Language: Английский

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Advancements in melanoma immunotherapy: the emergence of Extracellular Vesicle Vaccines

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Aug. 23, 2024

Abstract Malignant melanoma represents a particularly aggressive type of skin cancer, originating from the pathological transformation melanocytes. While conventional interventions such as surgical resection, chemotherapy, and radiation therapy are available, their non-specificity collateral damage to normal cells has shifted focus towards immunotherapy notable approach. Extracellular vesicles (EVs) naturally occurring transporters, capable delivering tumor-specific antigens directly engaging in immune response. Multiple types EVs have emerged promising platforms for vaccination. The effectiveness EV-based vaccines manifests ability potentiate response, by activating dendritic (DCs) CD8+ T lymphocytes, through engineering synergy antigen presentation targeted delivery. Here, this review mainly focuses on construction strategies EV various sources, effects, immunological mechanisms treating melanoma, well shortcomings future perspectives field. These findings will provide novel insights into innovative exploitation therapy.

Language: Английский

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Potential regulatory mechanism and clinical significance of synaptotagmin binding cytoplasmic RNA interacting protein in colorectal cancer

World Journal of Clinical Oncology, Journal Year: 2024, Volume and Issue: 15(11), P. 1412 - 1427

Published: Oct. 12, 2024

Colorectal cancer (CRC) causes many deaths worldwide. Synaptotagmin binding cytoplasmic RNA interacting protein (SYNCRIP) is an RNA-binding that plays important role in multiple cancers by epigenetically targeting some genes. Our study will examine the expression, potential effect, biological function and clinical value of SYNCRIP CRC.

Language: Английский

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