World Journal of Diabetes,
Journal Year:
2024,
Volume and Issue:
15(12), P. 2302 - 2310
Published: Nov. 14, 2024
Diabetic
retinopathy
(DR)
is
one
of
the
most
common
serious
complications
in
diabetic
patients,
and
early
screening
diagnosis
are
essential
to
prevent
visual
impairment.
With
rapid
development
deep
learning
technology,
network
models
based
on
attention
mechanisms
have
shown
significant
advantages
medical
image
analysis,
which
can
improve
accuracy
efficiency
screening.
World Journal of Gastrointestinal Surgery,
Journal Year:
2024,
Volume and Issue:
16(8), P. 2602 - 2611
Published: Aug. 16, 2024
This
study
investigated
the
construction
and
clinical
validation
of
a
predictive
model
for
neuroaggression
in
patients
with
gastric
cancer.
Gastric
cancer
is
one
most
common
malignant
tumors
world,
neuroinvasion
key
factor
affecting
prognosis
patients.
However,
there
lack
systematic
analysis
on
application
its
prediction
model.
adopted
single-center
retrospective
method,
collected
large
amount
data,
applied
statistics
machine
learning
technology
to
build
verify
an
effective
neuroaggression,
view
providing
scientific
basis
treatment
decisions
improving
effect
survival
rate
World Journal of Gastrointestinal Surgery,
Journal Year:
2024,
Volume and Issue:
16(9), P. 2893 - 2901
Published: Sept. 18, 2024
BACKGROUND
With
the
continuous
progress
of
colorectal
cancer
treatment
technology,
survival
rate
patients
has
improved
significantly,
but
problem
postoperative
neurocognitive
dysfunction
gradually
attracted
attention.
AIM
To
analyze
risk
factors
for
delayed
recovery
(DNR)
after
laparoscopic
surgery
and
constructed
a
prediction
model
to
provide
an
evidence-based
reference
prevention
DNR
surgery.
METHODS
The
clinical
data
227
with
who
underwent
regional
cerebral
saturation
oxygenation
(rScO2)
monitoring
at
our
hospital
from
March
2020
July
2022
were
retrospectively
analyzed.
Common
potential
affecting
used
as
analysis
variables,
univariate
multifactor
carried
out
step
by
determine
predictors
construct
model.
predictive
performance
was
assessed
receiver
operating
characteristic
(ROC)
curve,
calibration
curve
assess
fit
data,
nomogram
drawn.
In
addition,
30
met
inclusion
exclusion
criteria
January
2023
selected
external
verification
RESULTS
incidence
in
modeling
group
15.4%
(35/227).
Multivariate
revealed
that
age,
years
education,
diabetes
status,
lowest
rScO2
value
independent
influencing
(all
P
<
0.05).
Accordingly,
area
under
ROC
0.757
(95%CI:
0.676-0.839,
0.001),
Hosmer-Lemeshow
test
suggested
well
fitted
(P
=
0.516).
C-index
validation
row
0.617.
CONCLUSION
associated
can
be
individualized
assessment
undergoing
provides
basis
World Journal of Gastrointestinal Oncology,
Journal Year:
2024,
Volume and Issue:
16(10), P. 4064 - 4079
Published: Sept. 25, 2024
The
relevant
mechanism
of
tumor-associated
macrophages
(TAMs)
in
the
treatment
colorectal
cancer
patients
with
immune
checkpoint
inhibitors
(ICIs)
is
discussed,
and
application
prospects
TAMs
reversing
tolerance
ICIs
are
discussed
to
provide
a
reference
for
related
studies.
As
class
drugs
widely
used
clinical
tumor
immunotherapy,
can
act
on
regulatory
molecules
cells
that
play
an
inhibitory
role-immune
checkpoints-and
kill
tumors
form
response
by
activating
variety
system.
sensitivity
different
types
ICI
varies
greatly.
phenotype
function
microenvironment
closely
efficacy
ICIs.
regulate
phenotypic
TAMs,
also
affect
therapy.
important
role
resistance,
making
full
use
this
target
as
therapeutic
strategy
expected
improve
immunotherapy
prognosis
cancer.
World Journal of Gastrointestinal Surgery,
Journal Year:
2024,
Volume and Issue:
16(11), P. 3520 - 3530
Published: Oct. 30, 2024
BACKGROUND
Pseudomyxoma
peritonei
is
a
rare
tumor
that
can
produce
biological
behavior
similar
to
of
malignant
tumor.
Surgical
resection
combined
with
chemotherapy
the
traditional
treatment
method,
but
effect
not
good.
Cell
reduction
(CRS)
intraperitoneal
thermoperfusion
(HIPEC)
has
become
new
method
for
peritoneal
pseudomyxoma
(PMP).
AIM
To
find
out
if
CRS
and
HIPEC
be
used
safely
effectively
treat
PMP.
METHODS
This
an
observational
study.
Clinical
data
PMP
patients
treated
+
at
our
hospital
from
January
2013
June
2023
was
collated
analyzed.
The
main
outcome
measures
were
overall
survival
(OS),
secondary
incidence
surgical
complications
serious
adverse
events.
Complications
graded
according
common
event
evaluation
criteria.
Peritoneal
staging
performed
using
index
(PCI)
scoring
system,
cell
degree
(CCR)
score
after
CRS.
CCR-0
CCR-1
considered
satisfactory
RESULTS
A
total
186
included,
median
age
56
(48-64)
years,
65
(34.9%)
years
in
males,
121
(65.1%)
females.
PCI
28
(20-34)
points.
operative
time
300
(211-430)
minutes,
no
significant
occurred.
91.4%
(170/186)
appendix,
53.2%
(99/186)
low
grade,
30.6%
(57/186)
high
grade.
CCR
scores
showed
55
(29.6%)
achieved
CRS,
113
(60.8%)
did
achieve
fatality
rate
30
days
surgery
2.7%
(5/186),
1.6%
(3/186)
needed
second
operation,
90
4.3%
(8/186).
III-IV
43.0%
(80/186),
among
which
higher
mainly
anemia
(27.4%,
51/186),
electrolyte
disturbance
(11.6%,
21/181),
albumin
decrease
(7.5%,
14/186).
associated
abdominal
gastrointestinal
anastomotic
leakage
(2.2%,
4/186),
hemorrhage
infection
(4.3%,
8/186).
follow-up
38.1
(95%CI:
31.2-45.1)
months.
5-year
OS
50.3%
40.7%-59.9%),
66.1
43.1-89.1)
results
analysis
pathological
PCI,
had
(all
P
<
0.05).
88.9%
68.3%-100.0%)
patients,
77.6%
62.7%-92.5%)
42.0%
29.5%-54.5%)
CCR-2/3
patients.
CONCLUSION
application
safe
feasible,
benefit
high,
especially
those
who
significantly
extend
OS.
World Journal of Gastrointestinal Oncology,
Journal Year:
2024,
Volume and Issue:
16(8), P. 3436 - 3444
Published: Aug. 7, 2024
BACKGROUND
Gastric
cancer
(GC)
is
one
of
the
most
common
malignant
tumors
in
world,
and
its
prognosis
closely
related
to
many
factors.
In
recent
years,
incidence
vascular
thrombosis
patients
with
GC
has
gradually
attracted
increasing
attention,
studies
have
shown
that
it
may
a
significant
impact
on
survival
rate
patients.
However,
specific
mechanism
underlying
association
between
remains
unclear.
AIM
To
analyze
relationships
support
other
clinicopathological
factors
their
influence
GC.
METHODS
This
study
retrospectively
analyzed
data
621
divided
them
into
positive
group
negative
according
presence
or
absence
thrombus.
The
difference
5-year
cumulative
two
groups
was
compared,
thrombus
were
analyzed.
RESULTS
Among
GC,
thrombi
31.7%
(197
patients).
Binary
logistic
regression
analysis
revealed
degree
tumor
differentiation,
depth
invasion,
extent
lymph
node
metastasis
independent
influencing
for
occurrence
(P
<
0.01).
trend
χ
2
test
showed
linearly
correlated
percentage
0.01),
correlation
more
(r
=
0.387).
Univariate
significantly
lower
than
(46.7%
vs
73.3%,
P
Multivariate
age,
diameter,
TNM
stage,
risk
(all
0.05).
Further
stratified
stage
III
thrombolase-positive
thrombolase-negative
(36.1%
51.4%;
CONCLUSION
Vascular
status
an
factor
affecting
combination
suppositories
staging
can
better
judge
guide
reasonable
treatment.
World Journal of Gastrointestinal Oncology,
Journal Year:
2024,
Volume and Issue:
16(8), P. 3397 - 3409
Published: Aug. 7, 2024
Hepatocyte
growth
factor
(HGF)
and
its
receptor,
c-Met,
play
important
roles
in
the
occurrence,
development,
treatment
of
gastric
cancer
(GC).
This
review
explored
function
HGF/c-Met
signaling
pathway
GC
potential
targeted
therapeutic
mechanisms.
As
one
most
common
malignant
tumors
worldwide,
has
a
complex
pathogenesis
limited
options.
Therefore,
thorough
understanding
molecular
mechanism
is
very
for
development
new
methods.
The
plays
an
role
proliferation,
migration,
invasion
cells
become
target.
summarizes
current
research
progress
on
discusses
strategies
targeting
this
pathway,
providing
ideas
directions
GC.
World Journal of Gastrointestinal Surgery,
Journal Year:
2024,
Volume and Issue:
16(8), P. 2511 - 2520
Published: Aug. 16, 2024
Vascular
and
nerve
infiltration
are
important
indicators
for
the
progression
prognosis
of
gastric
cancer
(GC),
but
traditional
imaging
methods
have
some
limitations
in
preoperative
evaluation.
In
recent
years,
energy
spectrum
computed
tomography
(CT)
multiparameter
technology
has
been
gradually
applied
clinical
practice
because
its
advantages
tissue
contrast
lesion
detail
display.
World Journal of Gastrointestinal Surgery,
Journal Year:
2024,
Volume and Issue:
16(8), P. 2451 - 2460
Published: Aug. 16, 2024
With
the
development
of
minimally
invasive
surgical
techniques,
use
laparoscopic
D2
radical
surgery
for
treatment
locally
advanced
gastric
cancer
(GC)
has
gradually
increased.
However,
effect
this
procedure
on
survival
and
prognosis
remains
controversial.
This
study
evaluated
patients
receiving
resection
GC
to
provide
more
reliable
clinical
evidence,
guide
decision-making,
optimize
strategies,
improve
rate
quality
life
patients.
World Journal of Gastrointestinal Oncology,
Journal Year:
2024,
Volume and Issue:
16(9), P. 3781 - 3797
Published: Sept. 9, 2024
Erythropoietin-induced
hepatocyte
receptor
A2
(EphA2)
is
a
tyrosine
kinase
that
plays
key
role
in
the
development
and
progression
of
variety
tumors.
This
article
reviews
expression
EphA2
gastrointestinal
(GI)
colorectal
cancer
(CRC)
its
regulation
pyroptosis.
Pyroptosis
form
programmed
cell
death
an
important
tumor
suppression.
Studies
have
shown
regulates
pyrodeath
through
various
signaling
pathways,
affecting
occurrence,
metastasis
GI
CRC.
The
overexpression
closely
related
to
aggressiveness
CRC,
inhibition
can
induce
improve
sensitivity
cells
treatment.
In
addition,
intercellular
communication
microenvironment
interactions
with
other
cytokines
receptors,
further
influencing
progression.
CRC
underlying
mechanisms
provide
us
new
perspectives
potential
therapeutic
targets,
which
implications
for
future
