World Journal of Diabetes,
Journal Year:
2024,
Volume and Issue:
15(12), P. 2302 - 2310
Published: Nov. 14, 2024
Diabetic
retinopathy
(DR)
is
one
of
the
most
common
serious
complications
in
diabetic
patients,
and
early
screening
diagnosis
are
essential
to
prevent
visual
impairment.
With
rapid
development
deep
learning
technology,
network
models
based
on
attention
mechanisms
have
shown
significant
advantages
medical
image
analysis,
which
can
improve
accuracy
efficiency
screening.
World Journal of Gastrointestinal Oncology,
Journal Year:
2024,
Volume and Issue:
16(11), P. 4354 - 4368
Published: Oct. 25, 2024
The
relevant
mechanism
of
tumor-associated
macrophages
(TAMs)
in
the
treatment
colorectal
cancer
patients
with
immune
checkpoint
inhibitors
(ICIs)
is
discussed,
and
application
prospects
TAMs
reversing
tolerance
ICIs
are
discussed
to
provide
a
reference
for
related
studies.
As
class
drugs
widely
used
clinical
tumor
immunotherapy,
can
act
on
regulatory
molecules
cells
that
play
an
inhibitory
role
-
checkpoints
kill
tumors
form
response
by
activating
variety
system.
sensitivity
different
types
ICI
varies
greatly.
phenotype
function
microenvironment
closely
efficacy
ICIs.
regulate
phenotypic
TAMs,
also
affect
therapy.
important
resistance,
making
full
use
this
target
as
therapeutic
strategy
expected
improve
immunotherapy
prognosis
cancer.
World Journal of Gastrointestinal Oncology,
Journal Year:
2024,
Volume and Issue:
16(11), P. 4338 - 4353
Published: Oct. 25, 2024
The
receptor
tyrosine
kinase
encoded
by
the
MET
gene
plays
an
important
role
in
various
cellular
processes
such
as
growth,
survival,
migration
and
angiogenesis,
its
abnormal
activation
is
closely
related
to
occurrence
development
of
tumors.
This
article
reviews
recent
advances
diagnosis
treatment
MET-variant
digestive
tract
In
terms
diagnosis,
application
next-generation
sequencing
technology
liquid
biopsy
makes
detection
variants
more
accurate
efficient,
providing
a
reliable
basis
for
individualized
treatment.
treatment,
inhibitors
crizotinib
cabotinib
have
shown
good
efficacy
clinical
trials.
addition,
combination
immunotherapy
also
demonstrated
potential
synergies,
further
improving
therapeutic
effect.
However,
complexity
heterogeneity
drug
resistance
mechanisms
are
still
one
difficulties
current
research.
future,
it
necessary
deepen
understanding
mechanism
variation
explore
new
strategies
improve
overall
survival
rate
quality
life
patients.
tumors
moving
towards
precision
individualization,
broad
prospects.
World Journal of Diabetes,
Journal Year:
2024,
Volume and Issue:
15(12), P. 2302 - 2310
Published: Nov. 14, 2024
Diabetic
retinopathy
(DR)
is
one
of
the
most
common
serious
complications
in
diabetic
patients,
and
early
screening
diagnosis
are
essential
to
prevent
visual
impairment.
With
rapid
development
deep
learning
technology,
network
models
based
on
attention
mechanisms
have
shown
significant
advantages
medical
image
analysis,
which
can
improve
accuracy
efficiency
screening.
