Visualizing the Tumor Microenvironment: Molecular Imaging Probes Target Extracellular Matrix, Vascular Networks, and Immunosuppressive Cells DOI Creative Commons
Hui‐Wen Chan, Deng‐Yu Kuo, Pei‐Wei Shueng

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1663 - 1663

Published: Dec. 10, 2024

The tumor microenvironment (TME) is a critical factor in cancer progression, driving growth, immune evasion, therapeutic resistance, and metastasis. Understanding the dynamic interactions within TME essential for advancing management. Molecular imaging provides non-invasive, real-time, longitudinal approach to studying TME, with techniques such as positron emission tomography (PET), magnetic resonance (MRI), fluorescence offering complementary strengths, including high sensitivity, spatial resolution, intraoperative precision. Recent advances probe development have enhanced ability target monitor specific components of facilitating early diagnosis, monitoring, deeper insights into biology. By integrating these innovations, molecular offers transformative potential precision oncology, improving diagnostic accuracy treatment outcomes through comprehensive assessment dynamics.

Language: Английский

Overcoming immunotherapy resistance in gastric cancer: insights into mechanisms and emerging strategies DOI Creative Commons

D.Y. Luo,

Jing Zhou, Shuiliang Ruan

et al.

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 7, 2025

Abstract Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, with limited treatment options in advanced stages. Immunotherapy, particularly immune checkpoint inhibitors (ICIs) targeting PD1/PD-L1, has emerged as promising therapeutic approach. However, significant proportion patients exhibit primary or acquired resistance, limiting the overall efficacy immunotherapy. This review provides comprehensive analysis mechanisms underlying immunotherapy resistance GC, including role tumor microenvironment, dynamic PD-L1 expression, compensatory activation other checkpoints, and genomic instability. Furthermore, explores GC-specific factors such molecular subtypes, unique evasion mechanisms, impact Helicobacter pylori infection. We also discuss emerging strategies to overcome combination therapies, novel immunotherapeutic approaches, personalized based on genomics microenvironment. By highlighting these key areas, this aims inform future research directions clinical practice, ultimately improving outcomes for GC undergoing

Language: Английский

Citations

2
Targeting extracellular matrix interaction in gastrointestinal cancer: Immune modulation, metabolic reprogramming, and therapeutic strategies DOI

Jiyifan Li,

Wenxin Zhang, Lu Chen

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: unknown, P. 189225 - 189225

Published: Nov. 1, 2024

Language: Английский

Citations

4
Tumor-Associated Extracellular Matrix Obstacles for CAR-T Cell Therapy: Approaches to Overcoming DOI Creative Commons
Ilya Klabukov, Alexander E. Kabakov, A. O. Yakimova

et al.

Current Oncology, Journal Year: 2025, Volume and Issue: 32(2), P. 79 - 79

Published: Jan. 30, 2025

Chimeric antigen receptor (CAR)-T cell therapy yields good results in the treatment of various hematologic malignancies. However, efficacy CAR-T against solid tumors has proven to be limited, primarily because tumor-associated extracellular matrix (ECM) creates an intractable barrier for cytotoxic cells that are supposed kill cancer cells. This review unravels multifaceted role ECM impeding infiltration, survival, and functions within tumors. We analyze situations when intratumoral limits by being a purely physical complicates lymphocyte penetration/migration also acts as immunosuppressive factor impairs antitumor activities In addition, we highlight promising approaches such engineering with improved capabilities penetrate migrate into/through ECM, combination therapies aimed at attenuating high density potential others enable overcoming ECM-related obstacles. A detailed overview data relevant studies not only helps better understand interactions between but outlines ways more effectively use

Language: Английский

Citations

0
Adoptive immune cell therapy for colorectal cancer DOI Creative Commons
Chenxiao Liu, Nan Liu, Tongcun Zhang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

Colorectal cancer (CRC) is a major cause of cancer-related morbidity and mortality worldwide, with limited options for patients at advanced stages. Immunotherapy, particularly immune cell-based therapies, has gained significant attention as an innovative approach targeting CRC. This review summarizes the progress in various cell including DC vaccine, CAR/TCR-T cells, CAR-NK cells et al, each engineered to recognize attack expressing specific antigens. CAR-T therapy, which been successful hematologic cancers, faces challenges CRC due solid tumor microenvironment, limits infiltration persistence. CAR-M CAR-γδ T however, offer alternative strategies their unique properties, such ability target without prior sensitization lower risk inducing severe cytokine release syndrome. Recent advances lentiviral transduction have enabled effective expression CARs on NK γδ providing promising preclinical results models. explores mechanisms, targets, studies, early-phase clinical trials these addressing key enhancing specificity antigens overcoming immunosuppressive microenvironment. The potential combination checkpoint inhibitors also discussed some means improve effectiveness treatments Continued research essential translate approaches into settings, offering new hope patients.

Language: Английский

Citations

0
Visualizing the Tumor Microenvironment: Molecular Imaging Probes Target Extracellular Matrix, Vascular Networks, and Immunosuppressive Cells DOI Creative Commons
Hui‐Wen Chan, Deng‐Yu Kuo, Pei‐Wei Shueng

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1663 - 1663

Published: Dec. 10, 2024

The tumor microenvironment (TME) is a critical factor in cancer progression, driving growth, immune evasion, therapeutic resistance, and metastasis. Understanding the dynamic interactions within TME essential for advancing management. Molecular imaging provides non-invasive, real-time, longitudinal approach to studying TME, with techniques such as positron emission tomography (PET), magnetic resonance (MRI), fluorescence offering complementary strengths, including high sensitivity, spatial resolution, intraoperative precision. Recent advances probe development have enhanced ability target monitor specific components of facilitating early diagnosis, monitoring, deeper insights into biology. By integrating these innovations, molecular offers transformative potential precision oncology, improving diagnostic accuracy treatment outcomes through comprehensive assessment dynamics.

Language: Английский

Citations

0