FAPI-avid Lesions in the Brain DOI
Nasrin Raeisi, Amin Saber Tanha,

Farid Jafari Zarrin Ghabaei

et al.

Clinical Nuclear Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

A 63-year-old man presented with transient global amnesia, urinary incontinence, and a visual field deficit. MRI revealed heterogeneous mass in the left parieto-occipital lobe, diagnosed as glioblastoma multiforme (GBM). Following craniotomy, chemotherapy temozolomide radiotherapy were initiated. Two months after radiotherapy, indicated possible tumor recurrence, leading to change treatment. Despite further interventions, patient exhibited new-appearing symptoms significant increase size. 99m Tc-FAPI-46 scintigraphy showed avidity tumoral recurrence. This case highlights potential of this novel, low-cost imaging technique for assessing eligibility radio-ligand therapy resource-limited countries.

Language: Английский

Antitumor Activity, Mechanisms of Action and Phytochemical Profiling of Sub-Fractions Obtained from Ulex gallii Planch. (Fabaceae): A Medicinal Plant from Galicia (Spain) DOI Creative Commons
Lucía Bada, Hussain Shakeel Butt, Elías Quezada

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 972 - 972

Published: Feb. 19, 2025

The plant kingdom serves as a valuable resource for cancer drug development. This study explored the antitumor activity of different sub-fractions (hexane, dichloromethane and methanol) U. gallii (gorse) methanol extract in glioblastoma (U-87MG U-373MG) neuroblastoma (SH-SY5Y) cell lines, along with their phytochemical profiles. Cytotoxicity was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) lactate dehydrogenase (LDH) assays, cycle arrest apoptosis were assessed through flow cytometry by measuring reactive oxygen species (ROS) protein expression levels. D7 D8 significantly reduced viability, triggered early SH-SY5Y U-87MG cells specifically increased ROS levels cells. Western blot analyses showed that p53, caspase-3, caspase-8 γH2AX cells, while elevated p53 caspase-3 both lines. In U-373 markedly inducing necrosis. Morphological changes indicative also observed all Bioinformatic analysis UHPLC-MS GC-MS data tentatively identified 20 metabolites 15 D8, primarily flavonoids. HPLC-DAD confirmed isoprunetin genistein most abundant respectively, isolated NMR spectroscopy. Most flavonoids have been reported agents, suggesting these compounds may be responsible pharmacological activity.

Language: Английский

Citations

0
Knowledge structures and research hotspots of immunotherapy for brain metastasis, glioma, meningioma, and pituitary adenoma: A bibliometric and visualization review DOI

Donghu Yu,

Jin Wang, Lei Hu

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110995 - 110995

Published: Feb. 1, 2025

Language: Английский

Citations

0
FAPI-avid Lesions in the Brain DOI
Nasrin Raeisi, Amin Saber Tanha,

Farid Jafari Zarrin Ghabaei

et al.

Clinical Nuclear Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

A 63-year-old man presented with transient global amnesia, urinary incontinence, and a visual field deficit. MRI revealed heterogeneous mass in the left parieto-occipital lobe, diagnosed as glioblastoma multiforme (GBM). Following craniotomy, chemotherapy temozolomide radiotherapy were initiated. Two months after radiotherapy, indicated possible tumor recurrence, leading to change treatment. Despite further interventions, patient exhibited new-appearing symptoms significant increase size. 99m Tc-FAPI-46 scintigraphy showed avidity tumoral recurrence. This case highlights potential of this novel, low-cost imaging technique for assessing eligibility radio-ligand therapy resource-limited countries.

Language: Английский

Citations

0