RNF180 weakened the lipid droplet formation and subsequent chemoresistance by destabilizing ACC1 and ACLY in esophageal cancer DOI Creative Commons
Ning Li,

Dao-fu Shen,

Nanchang Yin

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 22, 2025

RNF180 (Ring finger protein 180) is an E3 ubiquitin-protein ligase that promotes polyubiquitination and proteasomal degradation. The study aimed to clarify the clinicopathological significances, signal pathways molecular mechanisms of expression in esophageal cancer. We analyzed significances cancer (EC) through bioinformatics pathological analysis. also clarified its effects on aggressiveness related vitro. mRNA was lower EC than normal tissues (p < 0.05), opposite for methylation 0.05). negatively correlated with promoter methylation, but positively high histological grading, N stage, poor prognosis associated T TNM unfavorable overall survival as independent factor differential genes can be categorized into olfactory transduction, focal adhesion, vascular smooth muscle contraction, calcium pathway, cell adhesion molecules, ECM receptor interaction, collagen degradation RNF180-related gastric acid insulin section, cardiomyopathy, glycoprotein binding, extracellular matrix, fat digestion diabetes, PPAR pathway peptidase activity. overexpression reduced proliferation, migration, invasion epithelial-mesenchymal transition, induce mitochondrial apoptosis, Caspase-1-dependent pyroptosis cells might chemosensitivity by weakening ACC1- ACLY-mediated lipogenesis via ubiquitination ACC1 ACLY, lipid droplet assembly. considered a biological marker aggressive behaviors target gene therapy.

Language: Английский

RNF180 weakened the lipid droplet formation and subsequent chemoresistance by destabilizing ACC1 and ACLY in esophageal cancer DOI Creative Commons
Ning Li,

Dao-fu Shen,

Nanchang Yin

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 22, 2025

RNF180 (Ring finger protein 180) is an E3 ubiquitin-protein ligase that promotes polyubiquitination and proteasomal degradation. The study aimed to clarify the clinicopathological significances, signal pathways molecular mechanisms of expression in esophageal cancer. We analyzed significances cancer (EC) through bioinformatics pathological analysis. also clarified its effects on aggressiveness related vitro. mRNA was lower EC than normal tissues (p < 0.05), opposite for methylation 0.05). negatively correlated with promoter methylation, but positively high histological grading, N stage, poor prognosis associated T TNM unfavorable overall survival as independent factor differential genes can be categorized into olfactory transduction, focal adhesion, vascular smooth muscle contraction, calcium pathway, cell adhesion molecules, ECM receptor interaction, collagen degradation RNF180-related gastric acid insulin section, cardiomyopathy, glycoprotein binding, extracellular matrix, fat digestion diabetes, PPAR pathway peptidase activity. overexpression reduced proliferation, migration, invasion epithelial-mesenchymal transition, induce mitochondrial apoptosis, Caspase-1-dependent pyroptosis cells might chemosensitivity by weakening ACC1- ACLY-mediated lipogenesis via ubiquitination ACC1 ACLY, lipid droplet assembly. considered a biological marker aggressive behaviors target gene therapy.

Language: Английский

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