Dual Role of HNF4α in Colorectal Adenocarcinoma During Carcinogenesis and Metastasis DOI Creative Commons
Ju Kim, Kyung‐Hee Kim, Jun Young Heo

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 599 - 599

Published: April 15, 2025

Hepatocyte nuclear factor 4α (HNF4α), a highly conserved member of the receptor superfamily transcription factors, has been identified as promising therapeutic candidate for colorectal adenocarcinoma (CRAC). This study was to investigate significance HNF4α in CRAC and mechanisms governing its function. The expression patterns clinical relevance were evaluated relation kappa B (NF-κb), Yes-associated protein (YAP), epithelial–mesenchymal transition markers. exhibited upregulation during carcinogenesis compared normal precancerous lesions. overexpression inhibition correlated with modulation cell migration invasion, either promoting or suppressing these processes. Notably, levels significantly diminished metastatic poorly differentiated relative primary samples. Moreover, reduced associated unfavorable prognostic factors. HNF4A induced decrease NF-κb levels, concomitant an increase YAP. Our results indicate dual role tumor progression, promotor inhibitor, depending on pathologic condition related signaling pathways. exhibits complex role, whereby is linked early progression metastasis CRAC.

Language: Английский

Dual Role of HNF4α in Colorectal Adenocarcinoma During Carcinogenesis and Metastasis DOI Creative Commons
Ju Kim, Kyung‐Hee Kim, Jun Young Heo

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 599 - 599

Published: April 15, 2025

Hepatocyte nuclear factor 4α (HNF4α), a highly conserved member of the receptor superfamily transcription factors, has been identified as promising therapeutic candidate for colorectal adenocarcinoma (CRAC). This study was to investigate significance HNF4α in CRAC and mechanisms governing its function. The expression patterns clinical relevance were evaluated relation kappa B (NF-κb), Yes-associated protein (YAP), epithelial–mesenchymal transition markers. exhibited upregulation during carcinogenesis compared normal precancerous lesions. overexpression inhibition correlated with modulation cell migration invasion, either promoting or suppressing these processes. Notably, levels significantly diminished metastatic poorly differentiated relative primary samples. Moreover, reduced associated unfavorable prognostic factors. HNF4A induced decrease NF-κb levels, concomitant an increase YAP. Our results indicate dual role tumor progression, promotor inhibitor, depending on pathologic condition related signaling pathways. exhibits complex role, whereby is linked early progression metastasis CRAC.

Language: Английский

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