Efferent methods of therapy for critical illness
Physical and rehabilitation medicine medical rehabilitation,
Journal Year:
2024,
Volume and Issue:
6(1), P. 49 - 72
Published: March 22, 2024
Extracorporeal
blood
purification
is
intended
to
eliminate
dysregulation
of
the
immune
system.
The
concept
extracorporeal
therapy
based
on
nonspecific
clearance
inflammatory
mediators
and
triggers,
which
attenuates
systemic
expression
mediators.
main
types
are
hemoadsorption
plasma
exchange.
Hemoadsorption
used
primarily
as
an
adjuvant
treatment
for
septic
shock
other
severe
conditions,
including
forms
COVID-19
with
cytokine
storm.
Reliable
data
demonstrating
benefit
in
critically
ill
patientsis
limited.
Recommendations
use
devices
often
incomplete
or
questionable
interpretations
available
data.
Given
lack
evidence
inflammation,
sepsis,
liver
failure
rhabdomyolysis,
its
routine
clinical
practice
not
justified
until
mechanisms
underlying
these
findings
fully
elucidated.
Plasma
replacement
a
potentially
life-saving
invasive
procedure
that
replaces
substitute
fluid
(saline,
albumin
solution,
fresh
frozen
plasma,
combination
these)
risk
side
effects
complications.
There
still
uncertainty
regarding
timing,
type
exchange,
volume
frequency
filtration.
Although
considered
be
relatively
safe,
there
insufficient
support
inclusion
sepsis
protocols.
Reports
methods
patients
refractory
inflammation
provide
decreased
levels
biomarkers,
improved
hemodynamic
parameters,
organ
failure.
However,
according
results
randomized
trials,
does
affect
outcomes,
some
even
increases
mortality.
To
clarify
effectiveness
therapy,
it
necessary
study
interaction
target
non-target
components
large-scale
controlled
trials
assessing
ability
this
improve
outcomes.
Language: Английский
Impact of extracorporeal hemadsorption on mortality in critically ill COVID-19 patients in the intensive care unit
The International Journal of Artificial Organs,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 13, 2024
Background:
The
consequences
of
COVID-19,
such
as
respiratory
failure
and
mortality,
require
the
search
for
fast
effective
solutions.
aim
this
retrospective
study
is
to
determine
effect
extracorporeal
hemadsorption
on
mortality
in
severe
COVID-19
cases
hospitalized
intensive
care
unit
(ICU).
Methods:
Our
retrospective,
single-center,
observational.
included
ICU
patients
diagnosed
with
who
received
treatment
between
March
2020
December
2020.
Effects
were
examined
by
comparing
pre-
post-hemadsorption
values.
Results:
Seventeen
study.
rate
was
64.7%.
After
hemadsorption,
an
increase
observed
lymphocyte
numbers,
APACHE-II,
SOFA
values
(
p
=
0.026,
0.043,
0.033;
respectively).
A
significant
decrease
CRP
fibrinogen
levels
0.003
0.005;
In
non-surviving
patient
group,
SOFA,
procalcitonin
found
be
high
before
after
procedure
0.002,
0.048,
0.06;
Conclusion:
patients,
APACHE-II
scores
may
useful
predicting
effectiveness
hemadsorption.
that
higher
at
baseline
had
a
These
findings
show
use
scoring
systems
determining
which
should
receive
performed
early
stages
disease.
Language: Английский
Beyond conventional care: The therapeutic potential of hemoperfusion in severe COVID-19
John Vásquez-Torres,
No information about this author
Ramsés Dávila-Collado,
No information about this author
Leyla Abdalah-Perez
No information about this author
et al.
World Journal of Critical Care Medicine,
Journal Year:
2024,
Volume and Issue:
13(4)
Published: Oct. 31, 2024
Hemoperfusion
(HP)
is
an
extracorporeal
blood
purification
modality
utilized
to
remove
small-
medium-sized
molecules,
such
as
toxins
and
cytokines,
that
are
difficult
by
conventional
hemodialysis.
In
clinical
practice,
HP
has
been
successfully
used
a
salvage
therapy
for
drug
overdose
occasionally
in
patients
with
liver
failure
sepsis.
Language: Английский
The effect of hemoperfusion on treatment outcomes in COVID-19 patients with respiratory failure: a prospective study
Effat Rafiee,
No information about this author
Samad Ghodrati,
No information about this author
Ayoub Pezeshgi
No information about this author
et al.
Immunopathologia Persa,
Journal Year:
2023,
Volume and Issue:
unknown
Published: July 29, 2023
Introduction:
COVID-19
emerged
as
a
global
clinical
threat
following
an
outbreak
in
China
late
2019.
Objectives:
The
aim
of
the
current
study
was
to
assess
effect
hemoperfusion
patients
with
respiratory
failure.
Patients
and
Methods:
In
this
prospective
study,
total
98
over
age
18
positive
polymerase
chain
reaction
(PCR)
test
were
investigated.
divided
into
two
groups;
control
group
consisting
47
who
did
not
receive
hemoperfusion,
exposed
51
met
criteria
for
hemoperfusion.
Various
parameters
including
complete
blood
cell
counts,
serum
bilirubin,
creatinine,
C-reactive
protein
(CRP),
interleukin
6
(IL-6)
levels
evaluated
all
patients.
Results:
results
our
revealed
statistically
significant
difference
intensive
care
unit
(ICU)
admission
between
groups.
Hospitalization
time
(19.941±1.75
versus
14.615±1.39,
P=0.021)
ICU
(14.98±1.30
9.62±1.15;
P=0.003)
significantly
higher
received
Regarding
mortality
rate,
only
36.7%
survived;
however,
there
no
observed
groups
(P=0.34).
Conclusion:
conclusion,
findings
indicate
that
failure
led
increase
hospital
stay
compared
those
without
Further
research
is
needed
determine
optimal
timing
frequency
improve
treatment
outcomes
Language: Английский