Cancer Drug Resistance,
Journal Year:
2023,
Volume and Issue:
unknown, P. 182 - 204
Published: Jan. 1, 2023
The
context-dependent
reciprocal
interaction
between
the
cancer
cells
and
surrounding
fibroblasts
is
imperative
for
regulating
malignant
potential,
metabolic
reprogramming,
immunosuppression,
ECM
deposition.
However,
recent
evidence
also
suggests
that
cancer-associated
induce
chemoresistance
in
to
various
anticancer
regimens.
Because
of
protumorigenic
function
fibroblasts,
these
stromal
cell
types
have
emerged
as
fascinating
therapeutic
targets
cancer.
this
notion
was
recently
challenged
by
studies
targeted
highlighted
underlying
heterogeneity
identifying
a
subset
with
tumor-restricting
functions.
Hence,
it
understand
heterotypic
signaling
target
tumor-promoting
processes
sparing
ones.
In
review,
we
discuss
shaping
drug
resistance
list
fibroblast-targeting
therapeutics.
Oncogenesis,
Journal Year:
2022,
Volume and Issue:
11(1)
Published: Aug. 9, 2022
Abstract
Lipids
are
essential
constituents
for
malignant
tumors,
as
they
absolutely
required
tumor
growth
and
dissemination.
Provided
by
the
microenvironment
(TME)
or
cancer
cells
themselves
through
activation
of
de
novo
synthesis
pathways,
orchestrate
a
large
variety
pro-tumorigenic
functions.
Importantly,
TME
cells,
especially
immune
cancer-associated
fibroblasts
(CAFs)
adipocytes
(CAAs),
also
prone
to
changes
in
their
lipid
content,
which
hinder
promote
aggressiveness.
In
this
review,
we
address
significant
findings
contribution
progression
towards
metastatic
disease
poor
response
therapeutic
treatments.
We
highlight
benefits
targeting
pathways
preclinical
models
slow
down
metastasis
development
overcome
chemo-and
immunotherapy
resistance.
Cancers,
Journal Year:
2022,
Volume and Issue:
14(5), P. 1231 - 1231
Published: Feb. 27, 2022
Cancer-associated
fibroblasts
(CAFs)
are
a
heterogenous
population
of
stromal
cells
found
in
solid
malignancies
that
coexist
with
the
growing
tumor
mass
and
other
immune/nonimmune
cellular
elements.
In
certain
neoplasms
(e.g.,
desmoplastic
tumors),
CAFs
prominent
mesenchymal
cell
type
microenvironment,
where
their
presence
abundance
signal
poor
prognosis
multiple
cancers.
play
major
role
progression
various
by
remodeling
supporting
matrix
into
dense,
fibrotic
structure
while
secreting
factors
lead
to
acquisition
cancer
stem-like
characteristics
promoting
survival,
reduced
sensitivity
chemotherapeutics,
aggressive
growth
metastasis.
Tumors
high
signatures
more
likely
be
associated
drug
resistance
eventual
relapse.
Clarifying
molecular
basis
for
such
multidirectional
crosstalk
among
normal
neoplastic
types
present
microenvironment
may
yield
novel
targets
new
opportunities
therapeutic
intervention.
This
review
highlights
most
recent
concepts
regarding
complexity
CAF
biology
including
heterogeneity,
functionality
resistance,
contribution
progressively
stroma,
involved
signaling
pathways
participating
genes.
Cells,
Journal Year:
2022,
Volume and Issue:
11(1), P. 140 - 140
Published: Jan. 2, 2022
Despite
the
numerous
investigations
on
resistance
mechanisms,
drug
in
cancer
therapies
still
limits
favorable
outcomes
patients.
The
complexities
of
inherent
characteristics
tumors,
such
as
tumor
heterogeneity
and
complicated
interaction
within
microenvironment,
hinder
efforts
to
overcome
cells,
requiring
innovative
approaches.
In
this
review,
we
describe
recent
studies
offering
evidence
for
essential
roles
amino
acid
metabolism
driving
cells.
Amino
acids
support
cells
counteracting
by
maintaining
redox
homeostasis,
sustaining
biosynthetic
processes,
regulating
epigenetic
modification,
providing
metabolic
intermediates
energy
generation.
addition,
impacts
anticancer
immune
responses,
creating
an
immunosuppressive
or
immunoeffective
microenvironment.
A
comprehensive
understanding
it
relates
therapeutic
mechanisms
will
improve
strategies.
Military Medical Research,
Journal Year:
2025,
Volume and Issue:
12(1)
Published: Feb. 11, 2025
Abstract
Cancer
recurrence,
driven
by
the
phenomenon
of
tumor
dormancy,
presents
a
formidable
challenge
in
oncology.
Dormant
cancer
cells
have
ability
to
evade
detection
and
treatment,
leading
relapse.
This
review
emphasizes
urgent
need
comprehend
dormancy
its
implications
for
recurrence.
Despite
notable
advancements,
significant
gaps
remain
our
understanding
mechanisms
underlying
lack
reliable
biomarkers
predicting
provides
comprehensive
analysis
cellular,
angiogenic,
immunological
aspects
dormancy.
It
highlights
current
therapeutic
strategies
targeting
dormant
cells,
particularly
combination
therapies
immunotherapies,
which
hold
promise
preventing
By
elucidating
these
proposing
innovative
research
methodologies,
this
aims
deepen
ultimately
facilitating
development
more
effective
recurrence
improving
patient
outcomes.
Cell Reports,
Journal Year:
2022,
Volume and Issue:
40(7), P. 111233 - 111233
Published: Aug. 1, 2022
5-Fluorouracil
(5-FU)
is
a
key
component
of
chemotherapy
for
colorectal
cancer
(CRC).
5-FU
efficacy
established
by
intracellular
levels
folate
cofactors
and
DNA
damage
repair
strategies.
However,
drug
resistance
still
represents
major
challenge.
Here,
we
report
that
alterations
in
serine
metabolism
affect
sensitivity
vitro
vivo
CRC
models.
In
particular,
5-FU-resistant
cells
display
strong
dependency
achieved
either
upregulating
endogenous
synthesis
or
increasing
exogenous
uptake.
Importantly,
regardless
the
feeder
strategy,
hydroxymethyltransferase-2
(SHMT2)-driven
compartmentalization
one-carbon
inside
mitochondria
specific
adaptation
resistant
to
support
purine
biosynthesis
potentiate
response.
Interfering
with
availability
affecting
its
mitochondrial
revert
resistance.
These
data
disclose
relevant
mechanism
use
supporting
provide
perspectives
therapeutic
approaches.
Molecular Therapy,
Journal Year:
2022,
Volume and Issue:
30(6), P. 2354 - 2369
Published: Feb. 19, 2022
Amino
acids
metabolism,
especially
aspartate
is
often
altered
in
human
cancers
including
hepatocellular
carcinoma
(HCC)
and
this
metabolic
remodeling
required
for
supporting
cancer
cell
malignant
activities.
Argininosuccinate
synthase
1
(ASS1),
as
a
crucial
rate-limiting
enzyme
participates
repressing
tumor
progression.
However,
the
roles
of
long
noncoding
RNAs
(lncRNAs)
metabolism
underlying
mechanisms
remain
unclear.
Here,
we
screen
LINC01234
an
metabolism-related
lncRNA
HCC.
Clinically,
was
highly
expressed
HCC,
high
expression
level
correlated
with
poor
prognosis
patients
promoted
proliferation,
migration,
drug
resistance
by
orchestrating
reprogramming
HCC
cells.
Mechanistically,
downregulated
ASS1,
leading
to
am
increased
activation
mammalian
target
rapamycin
pathway.
bound
promoter
ASS1
inhibited
transcriptional
factors,
p53.
Finally,
inhibiting
dramatically
impaired
growth
nude
mice
sensitized
cells
sorafenib.
These
findings
demonstrate
that
promotes
progression
modulating
might
be
prognostic
or
therapeutic
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2023,
Volume and Issue:
42(1)
Published: March 10, 2023
Metabolic
reprogramming
is
one
of
the
hallmarks
cancer.
As
nutrients
are
scarce
in
tumor
microenvironment
(TME),
cells
adopt
multiple
metabolic
adaptations
to
meet
their
growth
requirements.
not
only
present
cells,
but
exosomal
cargos
mediates
intercellular
communication
between
and
non-tumor
TME,
inducing
remodeling
create
an
outpost
microvascular
enrichment
immune
escape.
Here,
we
highlight
composition
characteristics
meanwhile
summarize
components
corresponding
sorting
mode.
Functionally,
these
cargos-mediated
improves
"soil"
for
metastasis.
Moreover,
discuss
abnormal
metabolism
targeted
by
its
potential
antitumor
therapy.
In
conclusion,
this
review
updates
current
role
TME
enriches
future
application
scenarios
exosomes.
