BCLAF1 drives esophageal squamous cell carcinoma progression through regulation of YTHDF2-dependent SIX1 mRNA degradation DOI
Peipei Zhang, Weiguang Zhang, Xiaoqing Wang

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 591, P. 216874 - 216874

Published: April 16, 2024

Language: Английский

LILRB4 Checkpoint for Immunotherapy: Structure, Mechanism and Disease Targets DOI Creative Commons

Zhiqing Xiang,

Xiangli Yin,

Leiyan Wei

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(2), P. 187 - 187

Published: Feb. 4, 2024

LILRB4, a myeloid inhibitory receptor belonging to the family of leukocyte immunoglobulin-like receptors (LILRs/LIRs), plays pivotal role in regulation immune tolerance. LILRB4 primarily mediates suppressive responses by transmitting signals through immunoreceptor tyrosine-based motifs (ITIMs). This checkpoint molecule has gained considerable attention due its potent regulatory functions. Its ability induce effector T cell dysfunction and promote suppressor differentiation been demonstrated, indicating therapeutic potential for modulating excessive responses, particularly autoimmune diseases or induction transplant Additionally, intervening with molecules, system responsiveness can be adjusted, representing significant value areas such as cancer treatment. Thus, emerged key player addressing diseases, tolerance induction, other medical issues. In this review, we provide comprehensive overview encompassing structure, expression, ligand molecules well receptor. By exploring involvement various significance disease progression is emphasized. Furthermore, propose that manipulation represents promising immunotherapeutic strategy highlight prevention, treatment diagnosis.

Language: Английский

Citations

8
The role of the methyltransferase METTL3 in prostate cancer: a potential therapeutic target DOI Creative Commons
Xuming Zhou,

Keqiang Chai,

Hezhen Zhu

et al.

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 2, 2024

Abstract The incidence of prostate cancer (PCa), the most prevalent malignancy, is currently at forefront. RNA modification a subfield booming field epigenetics. To date, more than 170 types modifications have been described, and N6-methyladenosine (m6A) abundant well-characterized internal mRNAs involved in various aspects progression. METTL3, first identified key methyltransferase, regulates human mRNA non-coding expression an m6A-dependent manner. This review elucidates biological function role METTL3 PCa discusses implications as potential therapeutic target for future research directions clinical applications.

Language: Английский

Citations

7
RNA N6-methyladenosine modifications in urological cancers: from mechanism to application DOI
Lei Yang, Jianming Ying, Qian Tao

et al.

Nature Reviews Urology, Journal Year: 2024, Volume and Issue: 21(8), P. 460 - 476

Published: Feb. 12, 2024

Language: Английский

Citations

7
Bioinformatic Analysis of m6A Regulator-Mediated RNA Methylation Modification Patterns and Immune Microenvironment Characterization in Endometriosis DOI
Weilin Zheng,

Zhiyi Fu,

Xi Tan

et al.

Biochemical Genetics, Journal Year: 2024, Volume and Issue: unknown

Published: March 7, 2024

Language: Английский

Citations

7
BCLAF1 drives esophageal squamous cell carcinoma progression through regulation of YTHDF2-dependent SIX1 mRNA degradation DOI
Peipei Zhang, Weiguang Zhang, Xiaoqing Wang

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 591, P. 216874 - 216874

Published: April 16, 2024

Language: Английский

Citations

7