Mechanistic and epidemiological evidence on the relationship between microbiota, virome and carcinogenesis DOI Creative Commons
Marianna G. Yakubovskaya, Timur I. Fetisov,

Л. Г. Соленова

et al.

Advances in molecular oncology, Journal Year: 2024, Volume and Issue: 11(4), P. 8 - 22

Published: Dec. 9, 2024

Recent development of molecular and genetic technologies has demonstrated at the level co-evolutionary principles interaction between microbiota, virome host organism, as well role microorganisms viruses both in maintaining physiological homeostasis various diseases, including malignant neoplasms. The presented review is devoted to analysis generalization modern data on inhabiting human body, their processes initiation, promotion progression carcinogenesis. provides information known oncogenic according classification carcinogenic agents International Agency for Research Cancer. Mechanistic procarcinogenic effect microbiota are considered accordance with concept key characteristics a agent. Particular attention paid influence immunity first results immunotherapy Coley toxin soft tissue sarcomas osteosarcomas, individual types formation immunocompetent cell profile organism. In addition, intratumor intracellular respectively, microenvironment tumor cells cellular signaling, solid tumors that have no contact external environment also discussed. important terms holobiota concept, showing interdependent existence viruses, improve prevention therapy

Language: Английский

Exploring the effects of gut microbiota on cholangiocarcinoma progression by patient-derived organoids DOI Creative Commons
Ann‐Kathrin Lederer,

Nele Görrissen,

Tinh Thi Nguyen

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 9, 2025

Language: Английский

Citations

1
A deadly taste: linking bitter taste receptors and apoptosis DOI Creative Commons
Zoey A. Miller, Ryan M. Carey, Robert J. Lee

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Humans can perceive five canonical tastes: salty, sour, umami, sweet, and bitter. These tastes are transmitted through the activation of ion channels receptors. Bitter taste receptors (Taste Family 2 Receptors; T2Rs) a sub-family 25 G-protein coupled receptor (GPCR) isoforms that were first identified in type II bud cells. T2Rs activated by broad array bitter agonists, which cause an increase intracellular calcium (Ca2+) decrease cyclic adenosine 3',5'-monophosphate (cAMP). Interestingly, expressed beyond oral cavity, where they play diverse non-taste roles cell physiology disease. Here, we summarize literature explores role apoptosis. Activation with agonists induces apoptosis several cancers, airway epithelia, smooth muscle, more. In many these tissues, T2R causes mitochondrial Ca2+ overload, main driver This response may be result cellular localization, nuclear mobilization and/or remnant established immunological other types. T2R-induced could pharmacologically leveraged to treat diseases altered proliferation. Future work must explore additional extra-oral T2R-expressing tissues for apoptotic responses, develop methods in-vivo studies, discover high affinity clinical application.

Language: Английский

Citations

0
Host-microbe-cancer interactions on-a-chip DOI Creative Commons

Mauricio G. C. Sousa,

Danielle S.K. Brasino, Madeline Krieger

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: March 31, 2025

The tumor microbiota has emerged as a pivotal contributor to variety of cancers, impacting disease development, progression, and therapeutic resistance. Due the complexity microenvironment, reproducing interactions between microbes, cells, immune system remains great challenge for both in vitro vivo studies. To this end, significant progress been made toward leveraging tumor-on-a-chip model systems replicate critical hallmarks native vitro. These microfluidic platforms offer ability mimic essential components including controllable fluid flow conditions, manipulable extracellular matrix dynamics, intricate 3D multi-cellular communication. primary objective review is discuss recent challenges advances engineering host-microbiota on-a-chip. Ultimately, overcoming these obstacles will help us gain deeper insights into tumor-microbe enhance avenues developing more effective cancer therapies.

Language: Английский

Citations

0
Circulating microbiome DNA features and its effect on predicting clinicopathological characteristics of patients with colorectal cancer DOI Creative Commons
Liang Ma,

Mingliang Shi,

Xue Zhang

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 13, 2025

Colorectal cancer (CRC) presents a complex tumor microenvironment influenced by genetic and microbial factors. Microbial DNA from the gut can translocate into bloodstream, forming circulating microbiome associated with prognosis clinicopathological features. This study investigates peripheral venous blood in CRC patients using 2bRAD-M sequencing evaluates its clinical significance. Peripheral samples 29 (19 males, 10 females; mean age 57 years) healthy controls were analyzed to assess diversity. Additionally, 20 tissue examined via RT-qPCR validate blood-tumor correlations. Statistical analyses evaluated associations between abundance features, including metastasis PD-L1 Combined Positive Score (CPS). Comparative performed identify disease-specific signatures. A total of 270 species identified, dominant phyla Actinomycetota, Bacillota, Bacteroidota, Pseudomonadota. Bosea lupini was significantly stage (p = 0.034), while Mycobacterium tuberculosis 0.022), Porphyromonas pasteri 0.017), 0.045) correlated CPS. Microbes such as lupini, Ralstonia mannitolilytica, suggested potential tumor-derived translocation bloodstream. identifies distinct patients, highlighting specific microbes features disease progression. These findings suggest microbiomes noninvasive biomarkers for therapeutic targets, warranting further investigation larger cohorts.

Language: Английский

Citations

0
Pseudomonas aeruginosa metabolite 3-oxo-C12HSL induces apoptosis through T2R14 and the mitochondrial calcium uniporter DOI
Zoey A. Miller,

Arielle Mueller,

Joel C. Thompson

et al.

Published: Oct. 29, 2024

Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal lining of upper aerodigestive tract. HNSCCs have high mortality rates current treatments can be associated with severe morbidities. It is vital to discover effective, minimally invasive therapies that improve survival quality life. We previously discovered bitter taste receptor 14 (T2R14), a GPCR, kills HNSCC cells when activated by agonists. are now investigating endogenous ligands exist tumor microenvironment (TME). The TME includes cells, signaling molecules, microbes greatly influence treatment responses overall prognosis HNSCC.

Language: Английский

Citations

2
Metabolic functions of misunderstood D-2-hydroxyglutarate DOI
Yidong Liu,

Zhaoqi Kang,

Wen Zhang

et al.

The Innovation Life, Journal Year: 2024, Volume and Issue: unknown, P. 100101 - 100101

Published: Jan. 1, 2024

<p>Isocitrate dehydrogenase mutation-induced D-2-hydroxyglutarate (D-2-HG) accumulation may promote the tumorigenesis of numerous cancers. D-2-HG produced by several promiscuous enzymatic reactions under normal conditions is also toxic to organisms. was thus previously viewed as an abnormal metabolite with no physiological function and conversion 2-ketoglutarate seems be a process repair. However, recent studies have revealed that production not meaningless without purpose. actually participates in many core metabolic processes, disorders these processes reason for some tumors lacking isocitrate mutation. This review summarizes diverse widely distributed involving D-2-HG, highlights functions generation from various precursors, discusses possible applications enzymes related metabolism synthetic biology, diagnosis, treatment accumulation-induced diseases.</p>

Language: Английский

Citations

1
An Explainable Graph Neural Framework to Identify Cancer‐Associated Intratumoral Microbial Communities DOI Creative Commons
Zhaoqian Liu, Yuhan Sun, Yingjie Li

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Abstract Microbes are extensively present among various cancer tissues and play critical roles in carcinogenesis treatment responses. However, the underlying relationships between intratumoral microbes tumors remain poorly understood. Here, a MIcrobial Cancer‐association Analysis using Heterogeneous graph transformer (MICAH) to identify cancer‐associated microbial communities is presented. MICAH integrates metabolic phylogenetic into heterogeneous representation. It uses holistically capture tissues, which improves explainability of associations identified cancers. applied bacterial data across 5 types fungi datasets, its generalizability reproducibility demonstrated. After experimentally testing representative observation mouse model tumor‐microbe‐immune interactions, result consistent with MICAH's relationship observed. Source tracking analysis reveals that primary known contributor community organs affected by type cancer. Overall, this neural network framework refines number can be used for follow‐up experimental validation from thousands tens, thereby helping accelerate understanding microbiomes.

Language: Английский

Citations

1
TIME Is Critical for Oncolytic Viral Therapies Against Solid Cancers DOI
Vijay Kumar, John H. Stewart

Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

1
Mechanistic and epidemiological evidence on the relationship between microbiota, virome and carcinogenesis DOI Creative Commons
Marianna G. Yakubovskaya, Timur I. Fetisov,

Л. Г. Соленова

et al.

Advances in molecular oncology, Journal Year: 2024, Volume and Issue: 11(4), P. 8 - 22

Published: Dec. 9, 2024

Recent development of molecular and genetic technologies has demonstrated at the level co-evolutionary principles interaction between microbiota, virome host organism, as well role microorganisms viruses both in maintaining physiological homeostasis various diseases, including malignant neoplasms. The presented review is devoted to analysis generalization modern data on inhabiting human body, their processes initiation, promotion progression carcinogenesis. provides information known oncogenic according classification carcinogenic agents International Agency for Research Cancer. Mechanistic procarcinogenic effect microbiota are considered accordance with concept key characteristics a agent. Particular attention paid influence immunity first results immunotherapy Coley toxin soft tissue sarcomas osteosarcomas, individual types formation immunocompetent cell profile organism. In addition, intratumor intracellular respectively, microenvironment tumor cells cellular signaling, solid tumors that have no contact external environment also discussed. important terms holobiota concept, showing interdependent existence viruses, improve prevention therapy

Language: Английский

Citations

0