Industry’s Path to a Greener Future: A Perspective on Current Sustainable Practices and Areas of Opportunity

ACS Sustainable Chemistry & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Language: Английский

Pd-Catalyzed Borylation in Water and Its Application to the Synthesis of Active Pharmaceutical Ingredient (API) Intermediates

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(17), P. 12452 - 12461

Published: Aug. 20, 2024

An efficient catalytic borylation reaction of aryl bromides in water based on Pd catalysis under micellar conditions is presented. The peculiar combination the proper precursor with a Sphos ligand and hindered lipophilic base ensures good yields synthesis wide range boronic esters, even for heteroaryl derivatives purity profile. method specifically developed situ preparation esters that are directly converted into examples relevant active pharmaceutical ingredient intermediates through cross-coupling reactions or via oxidation to phenols.

Language: Английский

Vigorously Stirred La2O3 Suspensions for Michael Additions in Water

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(73), P. 9994 - 9996

Published: Jan. 1, 2024

Vigorously stirred La 2 O 3 suspensions in water demonstrated exceptional efficiency ( e.g. high yields, short reaction times) for carbon–carbon bond formation. Water proved irreplaceable by organic solvents despite the reactant(s) being immiscible.

Language: Английский