More than Just Protein Folding: The Epichaperome, Mastermind of the Cancer Cell DOI Creative Commons
Haneef Ahmed Amissah, Maxwell Hubert Antwi,

Tawfeek Ahmed Amissah

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(3), P. 204 - 204

Published: Jan. 30, 2025

The epichaperome, a dynamic and integrated network of chaperone proteins, extends its roles beyond basic protein folding to stabilization intracellular signal transduction orchestrating multitude cellular processes critical for tumor survival. In this review, we explore the multifaceted delving into diverse locations, factors that modulate formation function, liquid–liquid phase separation, key signaling crosstalk pathways it regulates, including metabolism transduction. We further highlight techniques isolating identifying epichaperome networks, pitfalls, opportunities. Further, review profound implications cancer treatment therapy design, underscoring need strategic engineering hinges on comprehensive insight structure workings across heterogeneous cell subpopulations in milieu. By presenting holistic view epichaperome’s functions mechanisms, aim underscore potential as target novel anti-cancer strategies, revealing is not merely piece machinery but mastermind facilitates malignant phenotype.

Language: Английский

More than Just Protein Folding: The Epichaperome, Mastermind of the Cancer Cell DOI Creative Commons
Haneef Ahmed Amissah, Maxwell Hubert Antwi,

Tawfeek Ahmed Amissah

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(3), P. 204 - 204

Published: Jan. 30, 2025

The epichaperome, a dynamic and integrated network of chaperone proteins, extends its roles beyond basic protein folding to stabilization intracellular signal transduction orchestrating multitude cellular processes critical for tumor survival. In this review, we explore the multifaceted delving into diverse locations, factors that modulate formation function, liquid–liquid phase separation, key signaling crosstalk pathways it regulates, including metabolism transduction. We further highlight techniques isolating identifying epichaperome networks, pitfalls, opportunities. Further, review profound implications cancer treatment therapy design, underscoring need strategic engineering hinges on comprehensive insight structure workings across heterogeneous cell subpopulations in milieu. By presenting holistic view epichaperome’s functions mechanisms, aim underscore potential as target novel anti-cancer strategies, revealing is not merely piece machinery but mastermind facilitates malignant phenotype.

Language: Английский

Citations

0