Dialkylation of Alkenes to Fluorinated δ-Lactams Enabled by Nickel-Electron-Shuttle Catalysis

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

The δ-lactam motif is a privileged pharmacophore in drug design and development. While these biologically relevant molecules could be assembled through two-component cyclization, modular approach to constructing structures via multicomponent reaction with unactivated alkenes as starting materials rare. Herein, we report tandem that integrates alkene-dialkylation radical-involved ring-opening cyclization under single metal-electron-shuttle catalysis, which represents the most expeditious access fluorinated δ-lactams from simple alkenes.

Language: Английский

Iron-Catalyzed Alkylative Aminosulfonylation of Alkenes and Alkynes via Radical-Anion Relay

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

A novel Fe-catalyzed alkylative aminosulfonylation of alkenes and alkynes with alkyl halides O-Ts activated hydroxylamines by using Na2S2O4 as a reductant sulfone source has been developed. The metal-electron-shuttle catalysis was discovered to be vital for the highly efficient generation sulfonyl radicals anions without requiring organometallic intermediates. This method provides access sulfonamides from easily available features broad substrate scope.

Language: Английский