SARS-CoV-2 in Domestic UK Cats from Alpha to Omicron: Swab Surveillance and Case Reports

Published: Aug. 4, 2023

Although domestic cats are susceptible to infection with SARS-CoV-2, the role of virus in causing feline disease is less well defined. We conducted a large-scale study identify SARS-CoV-2 infections UK pet cats, using active and passive surveillance. Remnant respiratory swab samples, submitted for other pathogen testing between May 2021 February 2023, were screened RT-qPCR. In addition, we appealed veterinarians samples from suspected having clinical infections. Bespoke neutralising antibodies was also performed, on request, cases. One RT-qPCR-positive cat identified surveillance (1/549, 0.18 %), during Delta wave (1/175, 0.57 %). Passive detected one infected Alpha variant, two ten tested wave. No after emergence Omicron BA.1 its descendants although 374 by eleven describe four cases RT-qPCR and/or serology, that presented range signs, as their genome sequences. Our results demonstrate that, uncommon, can do occur.

Language: Английский

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SARS-CoV-2-induced Host Metabolic Reprogram (HMR): Nutritional Interventions for Global Management of COVID-19 and Post-Acute Sequelae of COVID-19 (PASC)

Journal of Food Bioactives, Journal Year: 2022, Volume and Issue: unknown, P. 1 - 42

Published: June 1, 2022

'Severe acute respiratory syndrome coronavirus 2' (SARS-CoV-2) is a highly transmissible viral pathogen responsible for the ongoing 'coronavirus disease 2019' (COVID-19) pandemic. The current re-purposed antiviral interventions against SARS-CoV-2 are classified into two major groups: Group-1 represents family of drugs, mainly vaccines that directly target virus, and Group-2 includes specific class inhibitors interfere with host-cell machinery, which critical infection replication. Global efforts to control COVID-19 pandemic repurposed therapeutics represent only phased victory. emergence several variants concern (VOCs) has compromised vaccinations pharma-therapeutic protocols, highlights dire necessity conserved domains, less likely mutate in genome. Several bioactive phytochemicals block enzymes such as nsp5/main proteinase (Mpro) RNA-dependent nsp7/nsp8/nsp12 RNA-polymerase (RdRp) complex, extensively investigated this direction. triggers complex human host-pathogen interaction(s) resulting 'host metabolic reprogramming' (HMR), iron (Fe)-redox dysregulation (FeRD), altered mitochondrial function cumulatively disrupt pathways involved cellular energy antioxidant enzyme function; thereby, compromise innate host defense. circulatory/RAAS axis contributes FeRD any alteration or imbalance Fe-redox homeostasis (Fe-R-H) may lead 'new onset' disorders (i.e., diabetes). Such inherent body damage its long-term health consequences post-acute sequelae (PASC) require effective nutritional intervention strategies, particularly at interface organ system functions immune dynamics. PASC indicate an accelerated rate exhaustion patients, due prolonged antigen stimulation (also vaccine exposure). Abnormal metabolism also cause systemic perturbations FeRD), ROS/RNS production, oxidative nitrosative stress, could trigger multi-organ ranging from mild symptoms incapacitating state reduced quality life last weeks longer following recovery COVID-19. five most clinical manifestations include fatigue, headache, attention disorder, hair loss, dyspnea. This narrative review elucidates intricate impairments associated eight physiological systems survivors pulmonary, neuro-cognitive, cardiovascular, renal, gastrointestinal/hepato-biliary, endocrinal, skeleton-muscular, reproductive) – triggered by FeRD, amplified HMR, ACE2/RAAS axis. We have attempted explain epidemic residual, non-viral complications supportive role system-targeted natural plant-based anti-inflammatories, immune-modulators, antioxidants, macro-/micronutrient optimizers manage PASC, newly emerged post-COVID syndrome.

Language: Английский

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Predictive Admission Risk Factors, Clinical Features and Kidney Outcomes in Covid-19 Hospitalised Patients with Acute Kidney Injury

PRILOZI, Journal Year: 2023, Volume and Issue: 44(3), P. 107 - 119

Published: Dec. 1, 2023

Introduction: In COVID-19 patients, acute kidney injury (AKI) is recognized as a cause of high mortality. The aim our study was to assess the rate and predictors AKI well survival among patients. Methods: We analyzed clinical laboratory admission data, outcomes including need for renal replacement therapy (RRT) mortality at 30 days. Results: Out 115 62 (53.9%) presented with AKI: 21 (33.9%) stage 1, 7(11.3%) 2, 34 (54.8%) 3. RRT required in 22.6% patients resolved 76%. Pre-existing CKD associated 13-fold risk (p= 0.0001). Low albumin (p = 0.017), thrombocytopenia 0.022) increase creatine kinase over 350UI 0.024) were independently higher AKI. Mortality rates significantly who developed compared those without (59.6% vs 30.2%, p= 0.003). oxygen blood saturation found powerful independent (OR 0.937; 95%CI: 0.917 - 0.958, p 0.000; OR 0.987; 0.885-0.991, 0.024, respectively). Longer observed (22.01± 1.703 16.69 ± 1.54, log rank 0.009). Conclusion: Renal impairment significant hospitalized severity disease itself emphasized main contributing mechanism occurrence AKI, lower strongest predictor, surpassing significance itself.

Language: Английский

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Epidemiological Characteristics and Mortality Risk Factors Comparison in Dialysis and Non-Dialysis CKD Patients with COVID-19—A Single Center Experience

Journal of Personalized Medicine, Journal Year: 2022, Volume and Issue: 12(6), P. 966 - 966

Published: June 13, 2022

(1) Background: Despite some controversies between studies, chronic kidney disease (CKD) has a negative impact on COVID-19 outcomes, with patients presenting higher mortality risk than in the general population. Studies have shown an association severe cases and different inflammatory biomarkers. The aim of this study was to emphasize epidemiological characteristics CKD diagnosed determine if mortality, severity infection might be influenced by parameters. (2) Methods: Our retrospective included COVID-19—362 non-dialysis group 132 dialysis group. (3) Results: There were significant statistical differences our groups regarding age (p < 0.001), hemoglobin interleukin-6 serum albumin = 0.016), procalcitonin 0.002), ferritin course creatinine 0.001). Even death (Exp(b) 1.839), survival proportions similar both groups. (4) Conclusions: High values hemoglobin, creatinine, LDH at admission, age, length hospital stay ≤ 10 days, pulmonary impairment > 25% are responsible for adverse outcome COVID-19.

Language: Английский

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Update on COVID-`9/Long Covid 19 how to Reorganize its Research Using AI Framework

American Journal of Biomedical Science & Research, Journal Year: 2022, Volume and Issue: 16(6), P. 659 - 678

Published: Aug. 11, 2022

From the start of COVID-19 pandemic until today more than 2 million SARS-CoV-2 genome sequences has been generated and shared that inform about outbreak control, disease surveillance, public health policy [1]. The "probable future many scientists now fears are is a virus shows no signs disappearing based on variants detected, where they adept by moving way to avoid human body's defenses". most important behavior observed "coronavirus evolved adaptation reinfect people, taking us being all our effort be prepared for long-term patterns survive among seems probability having different waves two or infections year it possible". An "additional accumulative problem millions people survived infection long symptoms".

Language: Английский

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