Clemastine enhances myelin formation in the striatum and medial prefrontal cortex and improves sociability in a neonatal rat hypoxic-ischemic model

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 185, P. 117916 - 117916

Published: March 9, 2025

Language: Английский

The potential of repurposing clemastine to promote remyelination

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: May 7, 2025

White matter in the central nervous system comprises bundled nerve fibers myelinated by oligodendrocytes. injury, characterized loss of oligodendrocytes and myelin, is common after ischemic brain inflammatory demyelinating diseases including multiple sclerosis, traumatic damage such as spinal cord injury. Currently, no therapies have been confirmed to promote remyelination these diseases. Over past decade, various reports suggested that anti-muscarinic drug clemastine can stimulate Consequently, repurposing a potential treatment for variety neurological disorders has gained significant attention. The therapeutic effects demonstrated animal models, its mechanisms action are currently being investigated. In this review, we summarize relating administration white injury disease discuss promotion.

Language: Английский

Microglia modulate integrity of myelin and proliferation of oligodendrocyte precursor cells in murine model of bone cancer pain

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177585 - 177585

Published: April 1, 2025

Language: Английский