Friend or foe: the role of platelets in acute lung injury DOI Creative Commons
Jichun Yang, Xun Zhou,

Xinrui Qiao

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 14, 2025

Lung diseases, including acute lung injury (ALI) and respiratory distress syndrome (ARDS), are associated with various etiological factors characterized by high mortality rates. Current treatment strategies primarily focus on lung-protective ventilation careful fluid management. Despite over 50 years of basic clinical research, effective options remain limited, the search for novel continues. Traditionally, platelets have been viewed as contributors to blood coagulation; however, recent research has revealed their significant role in inflammation immune regulation. While relationship between platelet count ALI/ARDS remained unclear, emerging studies highlight "dual role" these conditions. On one hand, interact neutrophils form neutrophil extracellular traps (NETs), promoting thrombosis exacerbating inflammation. other also play a protective modulating inflammation, regulatory T cell (Treg) activity, assisting alveolar macrophage reprogramming. This dual functionality important implications pathogenesis resolution ALI/ARDS. review examines multifaceted roles ALI/ARDS, focusing immunomodulatory effects, platelet-neutrophil interaction, critical involvement platelet-Treg complexes shaping inflammatory environment ALI.

Language: Английский

Macrophage pyroptosis and its crucial role in ALI/ARDS DOI Creative Commons

Yuju Cai,

Luorui Shang,

Fangyuan Zhou

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 14, 2025

Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS) is a severe clinical syndrome characterized by high morbidity and mortality, primarily due to injury. However, the pathogenesis of ALI/ARDS remains complex issue. In recent years, role macrophage pyroptosis in injury has garnered extensive attention worldwide. This paper reviews mechanism pyroptosis, discusses its ALI/ARDS, introduces several drugs intervening measures that can regulate influence progression ALI/ARDS. By doing so, we aim enhance understanding provide novel insights for treatment.

Language: Английский

Citations

2
Exosomal miR‐107 Derived From Cigarette Smoking‐Exposed Bronchial Epithelial Cells Aggravates Acute Lung Injury by Polarizing Macrophage to Proinflammatory Phenotype DOI
Xin Ni, Yufeng Lv, Lei Han

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(2)

Published: Feb. 1, 2025

ABSTRACT Exosomes are critical mediators of intercellular crosstalk and play significant roles in the progression various diseases including acute lung injury (ALI). However, specific role exosomes ALI remains largely unexplored. In investigation, we demonstrated that released from cigarette smoke extract (CSE)‐exposed bronchial epithelial cells (BEAS‐2B) facilitated M1 macrophage polarization. Notably, CSE exposure enhanced production miR‐107 within these exosomes. Inhibition markedly reversed polarization inflammatory responses vitro ameliorated vivo. Furthermore, exosomal was found to downregulate KLF4, thereby promoting inflammation macrophages. Collectively, findings demonstrate CSE‐exposed BEAS‐2B could induce via transmitting miR‐107, eventually ultimately contributing ALI, indicating a potential therapeutic strategy for ALI.

Language: Английский

Citations

0
Macrophage Notch1 Participates in LPS-Induced Acute Lung Injury via Regulating CCR5 Expression in Mice DOI Creative Commons

Ruiyu Zhang,

Hui Du, Zhi Liu

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(4)

Published: April 23, 2025

Background: As pivotal immunoregulatory sentinels in pulmonary defense systems, alveolar macrophages (AMs) play dual roles mediating inflammatory responses and tissue repair processes during various phases of cascades. The present investigation focuses on elucidating the regulatory influence Notch pathway activation within AM populations pathophysiological mechanisms underlying acute lung injury (ALI) development. Methods: To investigate intracellular domain (NICD) C-C chemokine receptor type 5 (CCR5) inflammation, an ALI model was established through lipopolysaccharide (LPS) administration. Complementary studies used macrophage-specific Notch1 knockout mice immortalized bone marrow-derived (iBMDMs). Molecular profiling CCR5 mediators performed real-time quantitative reverse transcription PCR (qRT-PCR) immunofluorescence staining. Functional assessments macrophage migration were carried out using scratch wound healing assays transwell assays. Results: In LPS-induced model, tissues exhibited elevated expression both NICD CCR5. Conversely, attenuated expression, reduced infiltration downregulated pro-inflammatory compared to wild-type controls (p < 0.05). Lung milder Notch1-deficient wild vitro experiments demonstrated that inhibiting CCL5-induced migration. Conclusion: signaling regulates response by modulating induced LPS.

Language: Английский

Citations

0
Friend or foe: the role of platelets in acute lung injury DOI Creative Commons
Jichun Yang, Xun Zhou,

Xinrui Qiao

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 14, 2025

Lung diseases, including acute lung injury (ALI) and respiratory distress syndrome (ARDS), are associated with various etiological factors characterized by high mortality rates. Current treatment strategies primarily focus on lung-protective ventilation careful fluid management. Despite over 50 years of basic clinical research, effective options remain limited, the search for novel continues. Traditionally, platelets have been viewed as contributors to blood coagulation; however, recent research has revealed their significant role in inflammation immune regulation. While relationship between platelet count ALI/ARDS remained unclear, emerging studies highlight "dual role" these conditions. On one hand, interact neutrophils form neutrophil extracellular traps (NETs), promoting thrombosis exacerbating inflammation. other also play a protective modulating inflammation, regulatory T cell (Treg) activity, assisting alveolar macrophage reprogramming. This dual functionality important implications pathogenesis resolution ALI/ARDS. review examines multifaceted roles ALI/ARDS, focusing immunomodulatory effects, platelet-neutrophil interaction, critical involvement platelet-Treg complexes shaping inflammatory environment ALI.

Language: Английский

Citations

0