The role and intrinsic connection of cellular senescence and cell death in inflammatory bowel disease DOI Creative Commons

Lichao Yang,

Lianwen Yuan

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: April 24, 2025

Cellular senescence in the intestine can induce cell death, which extends beyond mere clearance of senescent cells. This phenomenon is prevalent inflammatory and immune-related diseases, particularly bowel disease (IBD). IBD characterized by recurrent chronic intestinal inflammation, with occurrence development being influenced multiple factors, including genetics, environment, lifestyle, immunity, gut microbiota. Chronic inflammation drives aging immune system, reducing its efficiency impairing The disruption death regulation interplay between cellular contribute to progression IBD, inflammaging immunosenescence playing key role this process. However, mechanisms underlying context remain unclear. Therefore, paper comprehensively reviews impact on emphasizing exploration their potential interrelationships.

Language: Английский

The role and intrinsic connection of cellular senescence and cell death in inflammatory bowel disease DOI Creative Commons

Lichao Yang,

Lianwen Yuan

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: April 24, 2025

Cellular senescence in the intestine can induce cell death, which extends beyond mere clearance of senescent cells. This phenomenon is prevalent inflammatory and immune-related diseases, particularly bowel disease (IBD). IBD characterized by recurrent chronic intestinal inflammation, with occurrence development being influenced multiple factors, including genetics, environment, lifestyle, immunity, gut microbiota. Chronic inflammation drives aging immune system, reducing its efficiency impairing The disruption death regulation interplay between cellular contribute to progression IBD, inflammaging immunosenescence playing key role this process. However, mechanisms underlying context remain unclear. Therefore, paper comprehensively reviews impact on emphasizing exploration their potential interrelationships.

Language: Английский

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