Biocompatible Polyelectrolyte Multilayers with Copper Oxide and Zinc Oxide Nanoparticles for Inhibiting Bacterial Growth

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(11), P. 12550 - 12563

Published: May 17, 2024

The prevalence of bacterial infections presents a significant challenge in the medical field, demanding effective strategies to impede adhesion and growth on various surfaces. conducted study investigates efficacy polyelectrolyte multilayers─comprising poly(allylamine hydrochloride) (PAH) alginate (ALG)─embedded with zinc oxide (ZnO) copper (CuO) nanoparticles (NPs) inhibit stainless-steel Surface characterization involved zeta potential, contact angle, roughness assessments. effect NP composition, size, morphology conjunction polycation or polyanion terminating multilayers was evaluated against planktonic surface-adhered Escherichia coli (E. coli) cells. Surfaces positively charged PAH-terminating multilayer displayed higher water angles (≈ 63°) than negatively ALG-terminating 45°). Multilayers containing ZnO NPs showed inhibition E. growth, >99%. Moreover, complete achieved for both CuO. Due their larger specific surface area, rod-like antibacterial activity. samples ALG as layer more substantial properties PAH layer. Biocompatibility tests immortalized human keratinocyte cells revealed good compatibility incorporating NPs. In summary, this underscores potential CuO within PAH/ALG applications without compromising cytocompatibility.

Language: Английский

Recent Progress in Sputtered Metal-Based Thin Film Coatings for Biomedical Applications

Published: Dec. 28, 2024

Language: Английский