The RodentGPOmics Atlas: a comprehensive database of rodent biology for genomes and pathogens DOI Creative Commons

Zhiwen Jiang,

Ziqing Yan,

Yali Hou

et al.

Nucleic Acids Research, Journal Year: 2024, Volume and Issue: 53(D1), P. D1144 - D1150

Published: Dec. 6, 2024

Rodents represent the most abundant order of mammals, exhibiting remarkable diversity in morphology, habitats, behaviors, and hosted pathogens. Significant attention is currently focused on rodents as experimental animals for biomedical research. However, numerous aspects remain unexplored, such their potential unconventional models, molecular underpinnings intriguing complex phenotypes, adaptations to environment or climate change, host-pathogen interactions arms race evolution. These challenges require a systematic framework integrate genomic variations among with information rodent-borne To address this gap, we have established comprehensive, freely accessible, user-friendly atlas named Rodent Genome Pathogen multi-Omics (RodentGPOmics), which provides comparative analysis rodent genomes zoonotic pathogen sequences rodents. The RodentGPOmics Atlas provides: (i) basic 2706 species; (ii) chromosome-level visualization genomes, functional annotations, comparisons across 121 (iii) epidemiological profiles based 21 852 reported (iv) few tools in-depth exploration multi-omics. This resource aims advance development models humans promoting public health, well innovate genetics, genomics, evolution rodents, offer valuable knowledge emerging/re-emerging infectious diseases. resources are available easy-to-use at http://RodentGPOmics.njau.edu.cn:8888/Rodent/index/homePage.

Language: Английский

The RodentGPOmics Atlas: a comprehensive database of rodent biology for genomes and pathogens DOI Creative Commons

Zhiwen Jiang,

Ziqing Yan,

Yali Hou

et al.

Nucleic Acids Research, Journal Year: 2024, Volume and Issue: 53(D1), P. D1144 - D1150

Published: Dec. 6, 2024

Rodents represent the most abundant order of mammals, exhibiting remarkable diversity in morphology, habitats, behaviors, and hosted pathogens. Significant attention is currently focused on rodents as experimental animals for biomedical research. However, numerous aspects remain unexplored, such their potential unconventional models, molecular underpinnings intriguing complex phenotypes, adaptations to environment or climate change, host-pathogen interactions arms race evolution. These challenges require a systematic framework integrate genomic variations among with information rodent-borne To address this gap, we have established comprehensive, freely accessible, user-friendly atlas named Rodent Genome Pathogen multi-Omics (RodentGPOmics), which provides comparative analysis rodent genomes zoonotic pathogen sequences rodents. The RodentGPOmics Atlas provides: (i) basic 2706 species; (ii) chromosome-level visualization genomes, functional annotations, comparisons across 121 (iii) epidemiological profiles based 21 852 reported (iv) few tools in-depth exploration multi-omics. This resource aims advance development models humans promoting public health, well innovate genetics, genomics, evolution rodents, offer valuable knowledge emerging/re-emerging infectious diseases. resources are available easy-to-use at http://RodentGPOmics.njau.edu.cn:8888/Rodent/index/homePage.

Language: Английский

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