Regulation of epithelial growth factor receptors by the oncoprotein E5 during the HPV16 differentiation-dependent life cycle DOI Creative Commons
Mariano A. Molina,

Sneha Biswas,

Omar Jiménez-Vázquez

et al.

Tumour Virus Research, Journal Year: 2025, Volume and Issue: 19, P. 200315 - 200315

Published: March 7, 2025

Human papillomavirus (HPV) 16 infection initiates upon viral entry into the basal cells of epithelium. The virus manipulates signaling pathways to complete its life cycle, which depends on cellular differentiation. expresses oncoproteins E5, E6, and E7 promote immune evasion, cell cycle progression, apoptosis inhibition, replication. least studied oncoprotein is E5 (16E5), can regulate epithelial growth factor receptor (GFR) pathways. GFRs such as transforming factor-beta (TGFBR), epidermal (EGFR), keratinocyte (KGFR) have essential roles in growth, differentiation, proliferation. These receptors obtain their ligands from microenvironment, once activated, behavior therefore represent valuable targets for establish maintain a environment supportive infection. ability 16E5 proliferation differentiation varies through differentiating epithelium, making it necessary adequately describe association between GFRs. Here we summarize regulation GFR by 16E5, discuss stromal factors, outline unresolved questions over during HPV cycle.

Language: Английский

Regulation of epithelial growth factor receptors by the oncoprotein E5 during the HPV16 differentiation-dependent life cycle DOI Creative Commons
Mariano A. Molina,

Sneha Biswas,

Omar Jiménez-Vázquez

et al.

Tumour Virus Research, Journal Year: 2025, Volume and Issue: 19, P. 200315 - 200315

Published: March 7, 2025

Human papillomavirus (HPV) 16 infection initiates upon viral entry into the basal cells of epithelium. The virus manipulates signaling pathways to complete its life cycle, which depends on cellular differentiation. expresses oncoproteins E5, E6, and E7 promote immune evasion, cell cycle progression, apoptosis inhibition, replication. least studied oncoprotein is E5 (16E5), can regulate epithelial growth factor receptor (GFR) pathways. GFRs such as transforming factor-beta (TGFBR), epidermal (EGFR), keratinocyte (KGFR) have essential roles in growth, differentiation, proliferation. These receptors obtain their ligands from microenvironment, once activated, behavior therefore represent valuable targets for establish maintain a environment supportive infection. ability 16E5 proliferation differentiation varies through differentiating epithelium, making it necessary adequately describe association between GFRs. Here we summarize regulation GFR by 16E5, discuss stromal factors, outline unresolved questions over during HPV cycle.

Language: Английский

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