Low-intensity focused ultrasound to the human insular cortex differentially modulates the heartbeat-evoked potential: a proof-of-concept study DOI Creative Commons
Andrew Strohman,

G. Anand Isaac,

Brighton Payne

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 13, 2024

ABSTRACT Background The heartbeat evoked potential (HEP) is a brain response time-locked to the and marker of interoceptive processing. insula dorsal anterior cingulate cortex (dACC) are regions that may be involved in generating HEP. Low-intensity focused ultrasound (LIFU) non-invasive neuromodulation technique can selectively target sub-regions dACC better understand their contributions Objective Proof-of-concept study determine whether LIFU modulation (AI), posterior (PI), influences Methods In within-subject, repeated-measures design, healthy human participants (n=16) received 10 minutes stereotaxically targeted AI, PI, or Sham at rest during continuous electroencephalography (EEG) electrocardiography (ECG) recording on separate days. Primary outcome was change HEP amplitudes. Relationships between pressure changes were examined using linear mixed modelling. Peripheral indices visceromotor output including heart rate variability (HRV) explored conditions. Results Relative sham, but not AI dACC, decreased amplitudes; this partially explained by increased pressure. did affect time frequency dependent measures HRV. Conclusions These results demonstrate ability modulate amplitudes via targeting key regions. Our findings have implications for causal role these areas bottom-up heart-brain communication could guide future work investigating as processing clinical populations.

Language: Английский

Noninvasive neuromodulation of subregions of the human insula differentially affect pain processing and heart-rate variability: a within-subjects pseudo-randomized trial DOI Creative Commons
Wynn Legon, Andrew Strohman, Alexander In

et al.

Pain, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 1, 2024

The insula is an intriguing target for pain modulation. Unfortunately, it lies deep to the cortex making spatially specific noninvasive access difficult. Here, we leverage high spatial resolution and penetration depth of low-intensity focused ultrasound (LIFU) nonsurgically modulate anterior (AI) or posterior (PI) in humans effect on subjective ratings, electroencephalographic (EEG) contact heat-evoked potentials, as well autonomic measures including heart-rate variability (HRV). In a within-subjects, repeated-measures, pseudo-randomized trial design, 23 healthy volunteers received brief noxious heat stimuli dorsum their right hand during continuous heart-rate, electrodermal, electrocardiography EEG recording. Low-intensity was delivered AI (anterior short gyrus), PI (posterior longus under inert Sham condition. primary outcome measure rating. both similarly reduced ratings but had differential effects activity. affected earlier amplitudes, whereas LIFU later amplitudes. Only HRV indexed by increase SD N-N intervals mean low-frequency power. Taken together, effective method individually subregions site-specific brain biomarkers processing reactivity that translates perceived transient stimulus.

Language: Английский

Citations

24
Low-intensity focused ultrasound to the human dorsal anterior cingulate attenuates acute pain perception and autonomic responses. DOI Creative Commons
Andrew Strohman, Brighton Payne, Alexander In

et al.

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: unknown, P. e1011232023 - e1011232023

Published: Jan. 5, 2024

The dorsal anterior cingulate cortex (dACC) is a critical brain area for pain and autonomic processing, making it promising non-invasive therapeutic target. We leverage the high spatial resolution deep focal lengths of low-intensity focused ultrasound (LIFU) to non-invasively modulate dACC effects on behavioral cardiac responses using transient heat stimuli. N = 16 healthy human volunteers (6M/10F) received contact during either LIFU or Sham stimulation. Continuous electroencephalogram (EEG), electrocardiogram (ECG), electrodermal response (EDR) were recorded. Outcome measures included ratings, heart-rate variability, EDR response, blood pressure, amplitude heat-evoked potential (CHEP). reduced ratings by 1.09 ± 0.20 points relative Sham. increased heart rate variability indexed standard deviation normal sinus beats (SDNN), low frequency (LF) power, low-frequency/high-frequency (LF/HF) ratio. There no pressure EDR. resulted in 38.1% reduction P2 CHEP amplitude. Results demonstrate reduces alters acute This has implications causal understanding processing future options relief modulation homeostatic signals. Significance Statement New lines inquiry signals like (HRV) are aberrant chronic mental health disorders, which may contribute their underlying etiology. key center with direct influences function, but its depth precludes access without invasive surgery. For first time humans, we can selectively reduce perception, responses, work further establishes role clinical applications neuropsychological populations.

Language: Английский

Citations

19
A practical guide to transcranial ultrasonic stimulation from the IFCN-endorsed ITRUSST consortium DOI Creative Commons

Keith R. Murphy,

Tulika Nandi, Benjamin R. Kop

et al.

Clinical Neurophysiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

5
Non-invasive neuromodulation of sub-regions of the human insula differentially affect pain processing and heart-rate variability DOI Creative Commons
Wynn Legon,

Andrew Strohman,

Alexander In

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 5, 2023

ABSTRACT The insula is a portion of the cerebral cortex folded deep within lateral sulcus covered by overlying opercula inferior frontal lobe and superior temporal lobe. has been parsed into sub-regions based upon cytoarchitectonics structural functional connectivity with multiple lines evidence supporting specific roles for each these in pain processing interoception. In past, causal interrogation was only possible patients surgically implanted electrodes. Here, we leverage high spatial resolution combined penetration depth low-intensity focused ultrasound (LIFU) to non-surgically modulate either anterior (AI) or posterior (PI) humans effect on subjective ratings, electroencephalographic (EEG) contact head evoked potentials (CHEPs) time-frequency power as well autonomic measures including heart-rate variability (HRV) electrodermal response (EDR). N = 23 healthy volunteers received brief noxious heat stimuli dorsum their right hand during continuous heart-rate, EDR EEG recording. LIFU delivered AI (anterior short gyrus), PI (posterior longus gyrus) under an inert sham condition time-locked stimulus. Results demonstrate that single-element 500 kHz capable individually targeting gyri insula. both similarly reduced perceived ratings but had differential effects activity. affected earlier amplitudes around 300 milliseconds whereas milliseconds. addition, HRV indexed increase standard deviation N-N intervals (SDNN) mean low frequency power. There no blood pressure. Taken together, looks be effective method target site-specific brain biomarkers reactivity translates transient These data have implications treatment chronic several neuropsychological diseases like anxiety, depression addiction all abnormal activity concomitant dysregulated function.

Language: Английский

Citations

14
Low-intensity focused ultrasound to the posterior insula reduces temporal summation of pain DOI Creative Commons
Alexander In,

Andrew Strohman,

Brighton Payne

et al.

Brain stimulation, Journal Year: 2024, Volume and Issue: 17(4), P. 911 - 924

Published: July 1, 2024

The insula and dorsal anterior cingulate cortex (dACC) are core brain regions involved in pain processing central sensitization, a shared mechanism across various chronic conditions. Methods to modulate these may serve reduce though it is unclear which target be most efficacious for different measures of sensitization.

Language: Английский

Citations

5
Real-time Ultrasound Imaging System utilizing Patch-type Ultrasound Probe for Free-Flap Blood Perfusion Monitoring DOI
Yeonggeun Kim, Jun Hyeok Kim,

Yeon Hee Ryu

et al.

IEEE Sensors Journal, Journal Year: 2025, Volume and Issue: 25(5), P. 8898 - 8906

Published: Jan. 20, 2025

Language: Английский

Citations

0
Low-intensity focused ultrasound to the insula differentially modulates the heartbeat-evoked potential: a proof-of-concept study DOI
Andrew Strohman,

G. Anand Isaac,

Brighton Payne

et al.

Clinical Neurophysiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

3
Transcranial focused ultrasound-induced blood‒brain barrier opening in mice without shaving hairs DOI Creative Commons
Lu Xu, Yan Gong, Chih-Yen Chien

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 19, 2023

Acoustic coupling through hairs remains a challenge to performing transcranial-focused ultrasound procedures. Here, we demonstrated that this could be addressed by using oil as the medium, leveraging oil's high affinity due their inherent hydrophobicity. We compared focused ultrasound-induced blood-brain barrier opening (FUS-BBBO) outcomes in mice under three conditions: with ("oil + hairs"), gel hair shaving ("ultrasound no hair"), and hairs"). The quality of was evaluated [Formula: see text]-weighted magnetic resonance imaging (MRI) passive cavitation detection (PCD). outcome FUS-BBBO assessed MRI contrast agent extravasation vivo contrast-enhanced MRI. It also ex fluorescence mouse brain after intravenous injection model drug, Evans blue. results showed "oil hairs" consistently achieved high-quality acoustic without trapping air bubbles. not significantly different between "ultrasound hair" groups. These two groups had higher levels BBB than group. This study medium for transcranial FUS procedures hairs.

Language: Английский

Citations

6
Ultrasound neuromodulation: planning and validating treatments DOI Creative Commons
Michelle K. Sigona, Charles F. Caskey

Current Opinion in Behavioral Sciences, Journal Year: 2024, Volume and Issue: 59, P. 101430 - 101430

Published: July 29, 2024

Significant strides have been made in the translation of ultrasound neuromodulation for use humans. These advancements pivotal overcoming challenges associated with delivering to brain through skull. This undertaking has necessitated development specialized hardware, integration precise image guidance systems, and extensive research improve methods best plan enact transcranial focused (FUS) therapy. To validate optimize FUS procedures, various devised transmit, simulate, measure pressure fields. Here, we cover latest breakthroughs technology, a particular focus on efforts undertaken therapeutic interventions, ensuring their safety efficacy across diverse range subjects.

Language: Английский

Citations

2
A Comprehensive Overview of the Current Status and Advancements in Various Treatment Strategies against Epilepsy DOI Creative Commons
Abdul Waris, Muhammad Siraj, Ayyaz Ali Khan

et al.

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(12), P. 3729 - 3757

Published: Nov. 1, 2024

Epilepsy affects more than 70 million individuals of all ages worldwide and remains one the most severe chronic noncommunicable neurological diseases globally. Several neurotransmitters, membrane protein channels, receptors, enzymes, and, recently noted, various pathways, such as inflammatory mTORC complexes, play significant roles in initiation propagation seizures. Over past two decades, developments have been made diagnosis treatment epilepsy. Various pharmacological drugs with diverse mechanisms action other options developed to control seizures treat These include surgical treatment, nanomedicine, gene therapy, natural products, nervous stimulation, a ketogenic diet, gut microbiota, etc., which are developmental stages. Despite plethora options, one-third affected resistant current medications, while majority approved side effects, changes can occur, pharmacoresistance, effects on cognition, long-term problems, drug interactions, risks poor adherence, specific for certain psychological complications. Therefore, development new that no or minimal adverse is needed combat this deadly disease. In Review, we comprehensively summarize explain stages epilepsy well their status clinical trials advancements.

Language: Английский

Citations

2