Sulfated Polysaccharides with Anticoagulant Potential: A Review Focusing on Structure‐Activity Relationship and Action Mechanism

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(6)

Published: April 11, 2024

Thromboembolism is the culprit of cardiovascular diseases, leading to highest global mortality rate. Anticoagulation emerges as primary approach for managing thrombotic conditions. Notably, sulfated polysaccharides exhibit favorable anticoagulant efficacy with reduced side effects. This review focuses on structure-anticoagulant activity relationship and underlying action mechanisms. It concluded that chlorosulfonicacid-pyridine method serves preferred technique synthesize polysaccharides. The linked substitution site sulfate groups, degree substitution, molecular weight, main chain structure, glycosidic bond conformation. Moreover, exert via various pathways, including inhibition blood coagulation factors, activation antithrombin III heparin cofactor II, antiplatelet aggregation, promotion fibrinolytic system.

Language: Английский

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Effect of ultrasonic modification on physicochemical properties and bioactivity of polysaccharides from mycelium of Sanghuangporus vaninii

Journal of Food Measurement & Characterization, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Language: Английский

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Effects of extraction and modifications on physicochemical characteristics and bioactivities of lemon (Citrus limon L.) polysaccharides

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105943 - 105943

Published: Jan. 1, 2025

Language: Английский

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Dynamic high‐pressure microfluidization for the extraction and processing of polysaccharides: a focus on some foods and by‐products

Journal of the Science of Food and Agriculture, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Dynamic high‐pressure microfluidization (DHPM) is an emerging treatment technology and has been widely used for the recovery of natural polysaccharides. The aim present contribution to discuss DHPM‐assisted extraction processing polysaccharides from some foods by‐products by reviewing instrument working principle, procedures, key parameters, effects DHPM on structures, food properties, bioactivities resulting It was found that a with Z‐type chamber preferable extracting polysaccharides, Y‐type applicable solid‐to‐liquid ratio (or concentration), pressure, number passes are parameters influencing outcome processing. under suitable conditions conducive boosting yields enriching carbohydrates uronic acids in lowering protein impurities, transforming insoluble dietary fibers into soluble ones. In most cases, improved properties via decreasing viscosity, molecular weight, particle size, as well losing surface morphology. More importantly, mild technique barely affects chain backbones endowed enhanced antioxidant, hypolipidemic, hypoglycemic activities, exhibiting potential cardiovascular disease. addition, DHPM‐treated exerted certain whitening cosmetics inhibiting tyrosinase. conclusion, mild, efficient, green recover modify resources, especially by‐products. © 2025 Society Chemical Industry.

Language: Английский

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Structural analysis and bioavailability study of low-molecular-weight chondroitin sulfate‑iron complexes prepared by photocatalysis-Fenton reaction

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 342, P. 122435 - 122435

Published: June 25, 2024

Language: Английский

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