Uranium’s hazardous effects on humans and recent developments in treatment

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 293, P. 118043 - 118043

Published: March 1, 2025

Uranium, a naturally occurring element, is predominantly recognized for its role as fuel in both civilian and military energy sectors. Concerns have been raised regarding the adverse environmental impacts health risks associated with uranium mining due to exposure it causes. Such leads systemic toxicity, affecting pulmonary, hepatic, renal, reproductive, neurological, bone health. This review identifies significant research gaps detoxification methods contamination recommends further advancements, including genetic modification exploration of plant compounds. A comprehensive published materials from diverse sources uranium, various treatments hazardous on human body, was conducted. Additionally, PRISMA analysis performed this study. emphasizes importance collaboration formulation research-informed regulations effectively safeguard vulnerable communities consequences contamination. Public discourse often significance radiotoxicity; however, non-radioactive chemotoxicity has identified risk factor exposures, contingent upon species, enrichment, route. Given these serious consequences, several are being investigated ameliorate toxicity. In response concerns, techniques, such phytomedicinal treatments, biochemical approaches, chelation therapy, minimize effects body.

Language: Английский

Evaluating Cost‐Effective Strategies for Asymptomatic Microhematuria Diagnosis: A Risk‐Based Alternative to the American Urological Association Guidelines

Journal of Surgical Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

ABSTRACT Background and Objectives The American Urological Association (AUA) guidelines recommend evaluating asymptomatic microhematuria (MH) at ≥ 3 red blood cells per high powered field (RBCs/hpf), resulting in significant costs with limited bladder cancer detections. This study evaluates alternative diagnostic strategies to improve the cost‐effectiveness of MH evaluation. Methods analysis compared three strategies: Strategy 1 (cystoscopy 26 RBCs/hpf) was a RBCs/hpf threshold, while 2 renal ultrasound were AUA guidelines. Total costs, cost patient evaluated, detected, incremental ratios (ICERs) calculated. Results minimized without significantly reducing early detection rates. It cost‐effective for females (ICER = $120,649) total sample $50,648) but not specifically males $23,326). Strategies yielded lower savings less efficient. Conclusions 3—performing cystoscopy higher‐risk patients ( RBCs/hpf)—offers more approach than guidelines, particularly women. Future studies should incorporate additional variables test characteristics.

Language: Английский