The Multi-faceted Effects of COVID-19 on Female Reproductive Health: An Updated Narrative Review

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: April 9, 2024

Concerns about the SARS-CoV-2 pandemic's possible impact on sexual and reproductive health have grown significantly. In this narrative review, latest research effects of infection several facets is reviewed. The review starts initially by going through consequences female menstrual cycles. virus may interfere with cycle, which could affect hormone synthesis endometrial reactions, according to newly available evidence. Menstrual blood loss be impacted COVID-19's potential influence endothelial cell function systemic hemostasis. Hypothalamic amenorrhea brought severe COVID-19 disease. There little subject, although most women resume their regular cycles after 1-2 months recuperation. also examines how assisted technology (ART) treatments. are few clinical data, some points embryo quality. Overall, ART results, however, did not materially change from time before epidemic. Obstetric problems more likely when occurs during pregnancy, especially in third trimester. Even though maternal death rate still low, pregnant women, those comorbidities, experience serious sickness. emphasizes vaccine affects cycles, showing brief, modest modifications without hazards. Also included psychological family planning choices pandemic. conclusion, offers a thorough assessment complicated changing health. different requirements people couples pandemic highlighted, underscoring necessity for ongoing study specialized healthcare practices.

Language: Английский

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Fertility decline in the later phase of the COVID-19 pandemic: The role of policy interventions, vaccination programmes, and economic uncertainty

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 28, 2024

Abstract BACKGROUND During the COVID-19 pandemic, birth rates in most higher-income countries first briefly declined and then shortly recovered, showing no common trends afterwards until early 2022, when they unexpectedly dropped. STUDY FOCUS We analyse monthly changes total fertility during with a special focus on countries. consider three broader sets of explanatory factors: economic uncertainty, policy interventions restricting mobility social activities outside home, role vaccination programmes. DESIGN, DATA This study uses population-wide data adjusted for seasonality calendar effects provided Human Fertility Database (HFD, 2023). Births taking place between November 2020 October 2022 correspond to conceptions occurring February January i.e., after onset pandemic but prior Russian invasion Ukraine. The cover 26 countries, including 21 Europe, United States, Canada, Israel, Japan Republic Korea. METHODS First, we provide descriptive analysis rate (TFR). Second, estimate factors observed swings using linear fixed (within) regression models. MAIN RESULTS find that were associated as measured by increased inflation, stringency interventions, progression campaign, whereas unemployment did not show any link pandemic. LIMITATIONS, REASONS FOR CAUTION Our research is restricted relatively strong support policies government well wide access modern contraception. do allow analysing key characteristics, such age, order status. WIDER IMPLICATIONS OF THE FINDINGS multi-country drivers later phase In past, periods following epidemics health crises typically recovery fertility. contrast, our results gradual phasing out containment measures, allowing return more normal work life, contributed declining addition, indicates some women avoided pregnancy initial roll-out.

Language: Английский

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Vaccination in pregnancy

Frontiers in Global Women s Health, Journal Year: 2025, Volume and Issue: 5

Published: Jan. 13, 2025

Citation: Kennedy SH, MacDonald NE and Costa Clemens SA (2025) Vaccination in pregnancy. Front. Glob. Womens Health 5:1523117. doi: 10.3389/fgwh.2024.1523117

Language: Английский

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Unveiling the Impact of COVID-19 on Ovarian Function and Premature Ovarian Insufficiency: A Systematic Review

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 407 - 407

Published: Feb. 7, 2025

Background/Objectives: Premature ovarian insufficiency (POI) is a disorder that affects women under the age of 40. It characterized by decreased function, elevated gonadotropin levels, and estradiol. SARS-CoV-2 disrupts function largely through oxidative stress, inflammation, immunological dysregulation, which are enhanced its entrance into tissues via ACE2 receptors. The purpose this comprehensive review was to investigate molecular pathways link infection POI analyze their consequences for reserve fertility. Methods: We searched databases such as PubMed, Scopus, EMBASE, Google Scholar papers published between 2020 2024. Eligible studies investigated effects on including hormonal indicators anti-Müllerian hormone (AMH) follicle-stimulating (FSH), oocyte quality, reserve. data were compiled complete examination molecules clinical findings. Increased inflammatory indicators, interleukin-6 NLRP3 inflammasome activation, impaired homeostasis. Anti-SARS-CoV-2 antibodies in follicular fluid could have quality. Observational showed transitory decreases AMH changed FSH levels following infection, with variable antral follicle count IVF results. Changes lipid profiles VEGF expression emphasized virus's influence angiogenesis microenvironment. Conclusions: impairs causing disruption, thereby increasing incidence POI. While most alterations temporary, long-term reproductive remain unknown. Continuous monitoring specific treatments required reduce risks associated COVID-19.

Language: Английский

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Association between the COVID-19 vaccination campaign and fertility trends: a population-level time series analysis for 22 countries

BMJ Public Health, Journal Year: 2025, Volume and Issue: 3(1), P. e001410 - e001410

Published: Feb. 1, 2025

Introduction At the turn of 2021–2022, monthly birth rates declined in many higher-income countries. We explore how rollout COVID-19 vaccination was associated with this decline. Methods Using an interrupted time series design, we evaluate impact onset pandemic and start on seasonally adjusted total fertility 22 high-income study associations between by additionally controlling for youth unemployment, stringency index coverage. Fertility data come from Short-Term Fluctuations under Human Database. Indicators used as control variables originate Eurostat OECD databases, Oxford Government Response Tracker Our World Data. Results The had immediate effect most countries, although size direction level changes considerably varied across them. likewise extensive. While a relatively pronounced negative association vaccine 9 months later found only 10 out indications response were detected vast majority For several decline preceded increase that took place after pandemic. Only 4 countries post-vaccination declines resulted being lower than what pre-pandemic trend predicted. Additional changed little. Conclusions campaign contributed to variation short-term trends. Several experienced following campaign, which often returned closer trend. appears have responded short run vaccination, but few cases such long-term trajectory is below

Language: Английский

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Fertility dynamics through historical pandemics and COVID-19 in Switzerland, 1871–2022

Population Studies, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: March 11, 2025

We follow general fertility rates (GFRs) in Switzerland up to 2022, with a focus on their dynamics during and after pandemics. Historical influenza pandemics (1889–90, 1918–20, 1957) have consistently led temporary declines births between six nine months the pandemic peak. High of miscarriage may explain these findings. After 1889–90 1918–20 pandemics, short-term baby booms occurred. For recent Covid-19 pandemic, appear more complex. The GFR had already been declining since 2018, before hit Switzerland. During shortly first two waves 2020, there was an increase conceptions, leading higher 2021: shutdown measures brought planned pregnancies forwards. Subsequently, declined from February 2022; one possible explanation is that were intentionally postponed until vaccination. Following population-level observations, in-depth studies are needed understand better why affected by

Language: Английский

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Menstrual Cycle Length Changes Following Vaccination Against Influenza Alone or With COVID-19

JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(4), P. e257871 - e257871

Published: April 29, 2025

Multiple studies have identified an association between COVID-19 vaccination and menstrual disturbances. Data on whether health is impacted by other vaccines are needed to counsel individuals about what expect address vaccine hesitancy. To assess the of changes in length cycle with influenza vaccination, or without concurrent receipt a vaccine. This global retrospective cohort study prospectively collected data from April 25, 2023, February 27, 2024 (4-5 cycles per individual), among international English-speaking users digital birth control application. Participants included aged 18 45 years, not using hormonal contraception, average lengths 24 38 days 3 consecutive before vaccines. Seasonal The primary outcome consisted adjusted mean within-individual assessed group. Secondary analysis evaluated phase at time vaccination. A total 1501 met inclusion criteria, whom 791 were vaccinated for only 710 concurrently COVID-19. By race ethnicity, 1 participant (0.1%) was American Indian Alaska Native; 10 (0.7%), Asian; (0.2%), Black; 15 (1.0%), Hispanic Latina; (0.1%), Middle Eastern North African; 368 (24.5%), White; 19 (1.3%), other; 1084 (72.2%), missing. Most younger than 35 years (1230 [82.0%]), had least college degree (1122 [74.8%]), located US Canada (938 [62.5%]). Individuals alone experienced increase 0.40 (95% CI, 0.08-0.72) days, while those 0.49 0.16-0.83) (P = .69 difference groups). 37 (4.7%) change 8 42 (5.9%) both .28). In postvaccination cycle, groups returned their prevaccination lengths. Menstrual occurred follicular but luteal phase. this regular cycles, given combination associated small temporary length. These findings may help clinicians confirm utility patients concerns adverse effects

Language: Английский

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An exploration of women's decision-making processes around accepting or declining vaccinations in pregnancy: A qualitative descriptive study

Midwifery, Journal Year: 2025, Volume and Issue: 147, P. 104441 - 104441

Published: May 2, 2025

Language: Английский

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Association between inactivated COVID-19 vaccine and semen quality among males recovered from omicron infection: a retrospective cohort study

Expert Review of Clinical Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: May 15, 2025

The protective effects of inactivated COVID-19 vaccines against SARS-CoV-2-associated semen impairment remain underexplored. We investigated associations between BBIBP-CorV vaccination and the quality in males recovering from SARS-CoV-2 infection. This single-center retrospective cohort study included 1,496 infection at a tertiary hospital Urumqi, China (February-May 2023). Participants were categorized into long-term short-term groups based on interval collection their most recent assessed association different doses both groups. A total 1496 participants recruited for (n = 307) effect 1189). had median age 32 (IQR: 30, 35). Compared to unvaccinated controls, 2-dose 3-dose recipients showed reduced risks, with adjusted RR 0.945 (95% CI 0.918, 0.973) 0.965 0.937, 0.993), respectively. No significant results found Inactivated may protect among Omicron within 90 days, especially terms volume sperm progressive motility.

Language: Английский

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Effects of COVID-19 vaccination on human fertility: a post-pandemic literature review

Annals of Medicine, Journal Year: 2023, Volume and Issue: 55(2)

Published: Sept. 27, 2023

Although vaccination with the Coronavirus disease 2019 vaccine is important and effective in prevention of SARS-CoV-2 infection, public expressed concerns regarding adverse effects on fertility. Some reviews have focused it, they been unable to collect sufficient research data because earlier publication period. As relevant evidence has gradually increased, we reviewed these studies from perspectives males, females or without pregnancy, different types. The results suggest that although males may experience fluctuations semen parameters within their physiological ranges after receiving vaccine, it not yet reached a level influence partner's pregnancy probability. female believed will affect fertility; however, more needed explore short-term impact. Vaccination during any trimester considered safe pregnant women.

Language: Английский

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