Factors affecting motivation for receiving a booster dose of the COVID-19 vaccine among Japanese university students and staff: a cross-sectional questionnaire survey DOI Creative Commons
Sho Uchida, Shunsuke Uno, Masahiro Kondo

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 5, 2024

Abstract Understanding the factors that influence people’s decisions regarding vaccination is essential to promote vaccination. We aimed clarify motivations for receiving booster vaccines. conducted a paper-based questionnaire distributed during January–February 2022 involving students and faculty staff who received first COVID-19 at mass program June–September 2021 Keio University. A total of 1725 participants were enrolled, all completed survey. Among these, 64.9% reported significant adverse event (AEs) affecting daily life after second vaccine. “Fear severe illness” (72.6%) was most common reason getting vaccinated, followed by “concern infecting others” (68.4%) “fear infection itself” (68.3%). Television emerged as influential source information (80%), university (50.2%) social networking sites (42.8%). Multivariate analysis revealed illness”, itself”, “trust in efficacy safety vaccines general” significantly correlated with willingness receive paid vaccinations. The severity AEs not related participants’ Participants positive reasons more likely accept third dose.

Language: Английский

Sociobehavioural factors associated with SARS-CoV-2 infection and COVID-19 vaccine effectiveness against medically attended, symptomatic SARS-CoV-2 infection in the Philippines: a prospective case-control study (FASCINATE-P study) DOI Creative Commons
Ashley Arashiro, Regina Berba, Joy Potenciano Calayo

et al.

Western Pacific surveillance response journal, Journal Year: 2025, Volume and Issue: 16(1), P. 49 - 60

Published: March 31, 2025

We examined sociobehavioural factors associated with SARS-CoV-2 infection and estimated COVID-19 vaccine effectiveness against symptomatic in the Philippines. Such studies are limited low- middle-income countries, especially Asia Pacific. A case-control study was conducted two hospitals Manila, Philippines, from March 2022 to June 2023. Sociobehavioural vaccination history were collected. PCR-positive individuals cases, while PCR-negative controls. Adjusted odds ratios (aORs) calculated examine associations between factors/vaccination medically attended infection. The analysis included 2489 (574 positive 23.1%; 1915 controls, 76.9%; median age [interquartile range]: 35 [27-51] years). Although education household income not infection, being a health-care worker (aOR: 1.45; 95% confidence interval [CI]: 1.03-2.06). of higher among who gatherings five or more people compared those smaller 2.58; CI: 1.14-5.83). Absolute for status due high risk bias, example, unascertained prior Moderate relative first booster (32%; -120-79) second (48%; -23-78) observed (both wide CI), albeit waning trend after half year. workers emphasize importance prevention control measures. reiterates need efficacious vaccines caused by circulating variants longer duration protection.

Language: Английский

Citations

0
Single MVA-SARS-2-ST/N Vaccination Rapidly Protects K18-hACE2 Mice against a Lethal SARS-CoV-2 Challenge Infection DOI Creative Commons
Sabrina Clever, Leonard Limpinsel,

Christian Meyer zu Natrup

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(3), P. 417 - 417

Published: March 8, 2024

The sudden emergence of SARS-CoV-2 demonstrates the need for new vaccines that rapidly protect in case an emergency. In this study, we developed a recombinant MVA vaccine co-expressing prefusion-stabilized spike protein (ST) and nucleoprotein (N, MVA-SARS-2-ST/N) as approach to further improve vaccine-induced immunogenicity efficacy. Single MVA-SARS-2-ST/N vaccination K18-hACE2 mice induced robust protection against lethal respiratory challenge infection 28 days later. protective outcome correlated with activation SARS-CoV-2-neutralizing antibodies (nABs) substantial amounts SARS-CoV-2-specific T cells especially lung MVA-SARS-2-ST/N-vaccinated mice. Emergency just 2 before resulted delayed onset clinical disease these increased titers nAB or spleen lung. These data highlight potential multivalent COVID-19 S- N-protein, which contributes development strategies emerging pathogens.

Language: Английский

Citations

2
Fourth dose bivalent COVID-19 vaccines outperform monovalent boosters in eliciting cross-reactive memory B cells to Omicron subvariants DOI Creative Commons
Holly A. Fryer, Daryl Geers, Lennert Gommers

et al.

Journal of Infection, Journal Year: 2024, Volume and Issue: 89(4), P. 106246 - 106246

Published: Aug. 8, 2024

Bivalent COVID-19 vaccines comprising ancestral Wuhan-Hu-1 (WH1) and the Omicron BA.1 or BA.5 subvariant elicit enhanced serum antibody responses to emerging subvariants. Here, we characterized RBD-specific memory B cell (Bmem) response following a fourth dose with bivalent vaccine, in direct comparison WH1 monovalent dose. Healthcare workers previously immunized mRNA adenoviral vector were sampled before one month after vaccine. Serum neutralizing antibodies (NAb) quantified, as well Bmem an in-depth spectral flow cytometry panel including recombinant RBD proteins of WH1, BA.1, BA.5, BQ.1.1, XBB.1.5 variants. Both elicited higher NAb titers against subvariants compared Following either vaccine type, recipients had slightly increased numbers. significantly binding all tested by cytometry, while recognition was not vaccination. IgG1

Language: Английский

Citations

2
Bivalent COVID-19 vaccines boost the capacity of pre-existing SARS-CoV-2-specific memory B cells to cross-recognize Omicron subvariants DOI Creative Commons
Holly A. Fryer, Daryl Geers, Lennert Gommers

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 22, 2024

Abstract Bivalent COVID-19 vaccines comprising ancestral Wuhan-Hu-1 (WH1) and the Omicron BA.1 or BA.5 subvariant elicit enhanced serum antibody responses to emerging subvariants. We characterized memory B-cell (Bmem) response following a fourth dose with bivalent vaccine, compared immunogenicity WH1 monovalent dose. Healthcare workers previously immunized mRNA adenoviral vector were sampled before one-month after monovalent, vaccine. RBD-specific Bmem quantified an in-depth spectral flow cytometry panel including recombinant RBD proteins of WH1, BA.1, BA.5, BQ.1.1, XBB.1.5 variants. All recipients had slightly increased numbers. Recognition subvariants was not vaccination, while both significantly cross-recognition all tested by cytometry. Thus, Omicron-based can improve recognition descendent pre-existing, WH1-specific Bmem, beyond that conventional, This provides new insights into capacity variant-based booster immune against SARS-CoV-2

Language: Английский

Citations

0
Factors affecting motivation for receiving a booster dose of the COVID-19 vaccine among Japanese university students and staff: a cross-sectional questionnaire survey DOI Creative Commons
Sho Uchida, Shunsuke Uno, Masahiro Kondo

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 5, 2024

Abstract Understanding the factors that influence people’s decisions regarding vaccination is essential to promote vaccination. We aimed clarify motivations for receiving booster vaccines. conducted a paper-based questionnaire distributed during January–February 2022 involving students and faculty staff who received first COVID-19 at mass program June–September 2021 Keio University. A total of 1725 participants were enrolled, all completed survey. Among these, 64.9% reported significant adverse event (AEs) affecting daily life after second vaccine. “Fear severe illness” (72.6%) was most common reason getting vaccinated, followed by “concern infecting others” (68.4%) “fear infection itself” (68.3%). Television emerged as influential source information (80%), university (50.2%) social networking sites (42.8%). Multivariate analysis revealed illness”, itself”, “trust in efficacy safety vaccines general” significantly correlated with willingness receive paid vaccinations. The severity AEs not related participants’ Participants positive reasons more likely accept third dose.

Language: Английский

Citations

0