PCV13-Serotype Breakthrough Pneumococcal Disease in Infants Receiving High-Valency Conjugate Vaccines: Population-Level Modeling in France

Infectious Diseases and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Pneumococcal conjugate vaccines (PCVs) have been increasing in valency to protect against a larger number of serotypes; however, the addition serotypes has come at cost reduced immunogenicity, which may lead breakthrough disease. This study used mathematical model evaluate impact introducing routine vaccination with either PCV15 or PCV20 on invasive pneumococcal disease (bIPD) incidence associated PCV13 infants aged 0–12 months France. The incorporated historical PCV introductions and calibrated age- serotype-specific IPD data spanning 2000–2019. Serotype-specific vaccine effectiveness for was predicted based previously published analyses. bIPD evaluated across three serotype classes: PCV7 (serotypes 4, 6B, 9V, 14, 18C, 19F, 23F), PCV13-nonPCV7-nonST3 1, 5, 6A, 7F, 19A), ST3 (serotype 3). Results were compared 2019. Twenty years following introduction into childhood immunization program, use 2 + 1 regimen led fewer PCV13-nonPCV7-nonST3-associated cases than 3 regimen. all classes (– 28% – 89%) infants, largest ST3. both regimens resulted more from (+ 65% 350%), while increased 6%, respectively) but decreased 23% 30%, respectively), infants. Implementation could reduce due whereas substantial increases potentially resurgence Currently, 13-valent (PCV13) is routinely via dosing France, two novel higher PCVs (PCV15 regimen) recently recommended 9 V, regimen, (2 1) serotypes,

Language: Английский

The role of the microbiota in respiratory virus-bacterial pathobiont relationships in the upper respiratory tract

Published: Oct. 23, 2024

The mechanisms by which respiratory viruses predispose to secondary bacterial infections remain poorly characterized. Using 2,409 nasopharyngeal swabs from 300 infants in Botswana, we performed a detailed analysis of factors that influence the dynamics pathobiont colonization during infancy. We quantify extent increase acquisition

Language: Английский