Therapeutic Impact of Gardasil® in Recurrent Respiratory Papillomatosis: A Retrospective Study on RRP Patients

Viruses, Journal Year: 2025, Volume and Issue: 17(3), P. 321 - 321

Published: Feb. 26, 2025

Background: Recurrent respiratory papillomatosis (RRP) is a rare, non-malignant disease caused by human papillomavirus (HPV) types 6 and 11. The condition primarily affects the larynx, potentially leading to life-threatening airway obstruction. It more aggressive in younger patients, necessitating frequent surgical interventions. This study investigates therapeutic potential of prophylactic HPV vaccine Gardasil® RRP focusing on its impact lesion size frequency Furthermore, literature review was conducted analyze factors influencing decision vaccinate. Methods: A retrospective analysis 63 patients treated from 2008 2021. Disease burden assessed using Derkay score annual laser-surgical ablations. Comparisons were made between pre- post-vaccination periods vaccinated (n = 18), first second halves disease’s course unvaccinated 14). Results: reduction interventions (p < 0.05) could be seen. cumulated per year decreased after third vaccination 0.05). influenced multiple (e.g., side-effects, sociocultural factors, social media, pre-existing conditions wider context recent pandemic). Conclusions: appears reduce surgery lessen severity supporting role as option for RRP. Moreover, it crucial overcome skepticism towards vaccinations prevent development HPV-associated diseases place.

Language: Английский

Effect of School HPV Vaccination Requirements on Pediatricians’ Recommendations

Vaccines, Journal Year: 2024, Volume and Issue: 12(12), P. 1374 - 1374

Published: Dec. 6, 2024

Background/objectives: Pediatrician recommendations are highly influential in parents’ decisions to vaccinate their children against HPV. Unqualified, presumptive, and bundled (UPBRs) associated with increased HPV vaccine uptake considered best practice. This study analyzes pediatricians’ self-reported data assess changes UPBR use the psychosocial determinants of as a result implementation multi-level intervention, Adolescent Vaccination Program (AVP). Methods: We surveyed pediatricians across 51 clinics Houston area. Baseline surveys (n = 137) were distributed 2015, follow-ups 120) 2019. Results: significantly AVP implementation. Change provider belief that it is necessary tell parents vaccination not required for public school attendance predicted at follow up. was also significant mediator UPBRs follow-up. Conclusions: successful increasing UPBRs. related one critical determinant: beliefs about communication regarding non-mandatory nature enrollment. promotion efforts should devote focus changing necessity disclosing attendance.

Language: Английский

Healthcare Provider Recommendations for COVID-19 Vaccination: Prevalence, Disparities, and Correlates

Patient Education and Counseling, Journal Year: 2024, Volume and Issue: 130, P. 108481 - 108481

Published: Oct. 25, 2024

Language: Английский