Guided design for the development of an evolution-proof influenza vaccine DOI Creative Commons

Lauren Myburgh,

Karlijn van Loon, Elisabeth J. M. Huijbers

et al.

Vaccine, Journal Year: 2025, Volume and Issue: 59, P. 127281 - 127281

Published: May 20, 2025

Influenza remains a significant public health concern, particularly among high-risk populations, due to its capacity cause annual epidemics and potentially trigger global pandemics. Despite the availability of countermeasures such as vaccines antiviral treatments, their effectiveness is hindered by factors resistance development with manufacturing influenza vaccine still heavily relying on decades-old technologies. This review therefore examines mechanisms which viruses evade host immunity evaluates current emerging approaches enhance vaccine-mediated protection. Advances targeting conserved hemagglutinin (HA) stem, incorporating multiple HA subtypes, use adjuvants are discussed, alongside increased attention neuraminidase (NA) other viral components immunogenic targets. Strategic epitope prediction, through glycan masking, evolutionary forecasting, consensus sequence design, offer promising frameworks for rational design. Furthermore, delivery platforms, including recombinant protein, mRNA, conjugate explored potential elicit broad durable immunity. Collectively, these developments highlight multifaceted approach towards design effective interventions against this persistent healthcare challenge.

Language: Английский

Guided design for the development of an evolution-proof influenza vaccine DOI Creative Commons

Lauren Myburgh,

Karlijn van Loon, Elisabeth J. M. Huijbers

et al.

Vaccine, Journal Year: 2025, Volume and Issue: 59, P. 127281 - 127281

Published: May 20, 2025

Influenza remains a significant public health concern, particularly among high-risk populations, due to its capacity cause annual epidemics and potentially trigger global pandemics. Despite the availability of countermeasures such as vaccines antiviral treatments, their effectiveness is hindered by factors resistance development with manufacturing influenza vaccine still heavily relying on decades-old technologies. This review therefore examines mechanisms which viruses evade host immunity evaluates current emerging approaches enhance vaccine-mediated protection. Advances targeting conserved hemagglutinin (HA) stem, incorporating multiple HA subtypes, use adjuvants are discussed, alongside increased attention neuraminidase (NA) other viral components immunogenic targets. Strategic epitope prediction, through glycan masking, evolutionary forecasting, consensus sequence design, offer promising frameworks for rational design. Furthermore, delivery platforms, including recombinant protein, mRNA, conjugate explored potential elicit broad durable immunity. Collectively, these developments highlight multifaceted approach towards design effective interventions against this persistent healthcare challenge.

Language: Английский

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